rifampin and Colonic-Diseases

Topics: Animals; Animals, Newborn; Anti-Infective Agents; Bronchopneumonia; Candidiasis; Colonic Diseases; Death, Sudden; Diagnosis, Differential; Diarrhea; Horse Diseases; Horses; Male; Rifampin; Spiramycin

Topics: Administration, Oral; Aged; Antitubercular Agents; Colonic Diseases; Desensitization, Immunologic; Dose-Response Relationship, Drug; Drug Eruptions; Drug Therapy, Combination; Female; Humans; Rifampin; Tuberculosis, Gastrointestinal; Tuberculosis, Lymph Node

Two cases of colonic tuberculosis (TB) isolated in two elderly, not HIV seropositive women, presenting unspecific clinical manifestations (constitutional syndrome, fever, abdominal pain and diarrhea) and stenosis of the colon in diagnostic imaging techniques are presented. In the second case, endoscopy showed stenosis of the colonic lumen and inflammatory mucosa, the biopsy of which demonstrated granulation tissue with no signs of specificity (in the first case, technical problems did not allow the colonoscopy to reach the affected site). In both cases, diagnosis was performed postoperatively by study of the surgical pieces. Biopsy showed granulomas with acid-alcohol resistant bacilli. Both patients responded favorably to tuberculostatic treatment.

Topics: Aged; Antibiotics, Antitubercular; Antitubercular Agents; Colonic Diseases; Colonoscopy; Female; Humans; Isoniazid; Pyrazinamide; Rifampin; Tuberculosis, Gastrointestinal

A 67-year-old woman had developed weakness, fatigue and a 10 kg weight loss over the past year. On examination a cylindrical mass was palpated in the right middle abdominal cavity. Erythrocyte sedimentation rate was increased to 87/126 mm, there was an hypochromic anaemia (haemoglobin 9.1 mg/dl) and an hypoalbuminaemia (32 g/l) with an increase in alpha 2-globulins (9.4 g/l), Cholinesterase activity was decreased to 588 U/l. X-ray film of the abdomen revealed a calcified mesenteric lymph-node and coloscopy demonstrated polypoid tumorous changes with ulcerations, extending from the pole of the caecum to the right flexure. Histological examination showed epithelioid-cell granulomas with Langhans giant cells. Culture grew Mycobacterium tuberculosis, confirming the diagnosis of intestinal tuberculosis. She was treated with oral doses of isoniazid (300 mg daily), rifampicin (600 mg daily) and pyrazinamide (2 g daily) for 2 months, followed by isoniazid and rifampicin for a further 4 months. After this the laboratory tests were within normal limits and urine as well as stool samples contained no acid-fast bacilli. As the patient felt so well she declined another coloscopy.

Topics: Aged; Cecum; Colon; Colonic Diseases; Colonoscopy; Drug Therapy, Combination; Female; Humans; Isoniazid; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Tuberculosis, Gastrointestinal