rifampin and Cerebral-Infarction

Septic cavernous sinus thrombosis is a rare clinical condition. Although Staphylococcus aureus is the most common pathogen causing septic cavernous sinus thrombosis [CST], it is an uncommon cause of meningitis. We report the first case of CST with meningitis in Hyderabad, Andhra Pradesh, caused by community acquired epidemic strain of Methicillin resistant staphylococcus aureus [MRSA], in a previously healthy individual with no risk factors. The patient recovered completely following treatment with Vancomycin. We consecutively reviewed all cases of community acquired staphylococcus aureus [CA-MRSA] with central nervous system involvement available in literature.

Topics: Adolescent; Basal Ganglia Cerebrovascular Disease; Brain; Cavernous Sinus Thrombosis; Cerebral Infarction; Community-Acquired Infections; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Meningitis, Bacterial; Methicillin-Resistant Staphylococcus aureus; Rifampin; Staphylococcal Infections

Topics: Adult; Anaphylaxis; Antibiotics, Antitubercular; Antitubercular Agents; Cerebral Infarction; Drug Hypersensitivity; Drug Therapy, Combination; HIV Infections; Humans; Isoniazid; Male; Pyrazinamide; Rifampin; Tuberculosis, Pulmonary

Topics: Adult; Bacteremia; Cefotaxime; Cerebral Infarction; Cerebrospinal Fluid; Epilepsies, Partial; Female; Humans; Immunocompetence; Meningitis, Haemophilus; Meningitis, Pneumococcal; Recurrence; Rifampin

A case of tuberculous brain infection following tuberculous meningitis in a 67-year-old man is presented. It was located in an old cerebral infarct associated with left internal carotid artery occlusion. CT demonstrated capsule enhancement in the left temporal area after iodinated contrast medium. Chemotherapy with INH, RFP and SM diminished the lesion and the capsule disappeared thirteen months later. It is suggested that a relatively long clinical history together with the appearance of a thick-walled abscess-like lesion on the CT scan is consistent with the diagnosis of tuberculous brain infection, perhaps an abscess.

Topics: Aged; Brain Abscess; Cerebral Infarction; Humans; Isonicotinic Acids; Male; Rifampin; Streptomycin; Tomography, X-Ray Computed; Tuberculosis; Tuberculosis, Meningeal

Two patients with tuberculous meningitis and internuclear ophthalmoplegia are described. Despite treatment with anti-tuberculosis chemotherapy and corticosteroids, both patients died. In one case autopsy showed severe basal meningitis with diffuse brain stem infarction secondary to widespread vasculitis.

Topics: Adult; Brain Stem; Cerebral Infarction; Dexamethasone; Drug Therapy, Combination; Endarteritis; Humans; Isoniazid; Male; Middle Aged; Ophthalmoplegia; Prognosis; Pyrazinamide; Rifampin; Tuberculosis, Meningeal

Topics: Adult; Aphasia; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Infarction; Cerebral Ventricles; Cerebrospinal Fluid; Encephalitis; Female; Humans; Male; Middle Aged; Rifampin; Streptomycin; Tuberculosis, Meningeal; Tuberculosis, Miliary; Tuberculosis, Renal