rifampin and Cerebral-Hemorrhage

Cerebritis y abscesos cerebrales por Streptococcus pneumoniae en un recien nacido.

Topics: Anti-Bacterial Agents; Anticonvulsants; Bacteremia; Brain Abscess; Bronchiolitis; Cardiotonic Agents; Cerebral Hemorrhage; Drug Therapy, Combination; Fatal Outcome; Humans; Immunocompromised Host; Infant, Newborn; Magnetic Resonance Imaging; Male; Meningitis, Pneumococcal; Pneumococcal Infections; Respiratory Syncytial Virus Infections; Rifampin; Spleen; Streptococcus pneumoniae; Vancomycin

Brain abscesses are a rare but potentially lethal neurological lesions, generally occurring after septic episodes in immunodeficient patients or complicating neurosurgical procedures. Even though they are known complications of surgically treated intracerebral haemorrhages (ICH), the presence of a brain abscess at the site of an untreated ICH is a rare event. Such cases may result from haematogenous spread from distant foci or contiguous sites and are often preceded by episodes of sepsis and local infection. Immunodeficiency, AIDS, age, diabetes mellitus and vitamin-K deficiency are predisposing factors. Abscess formation should be considered in case of clinical deterioration, headache, and any neurological deficit after febrile episodes. Early diagnosis with neuroradiological imaging, infection blood markers and microbiological identification of the causative pathogen is crucial for treatment with surgical drainage or excision and specific antibiotic therapy, which guarantee good outcome and long-term survival. In fact, while prompt diagnosis and treatment guarantee good outcome and long-term survival, morbidity and mortality are very high in case of misdiagnosis. We report a case of a 49-year old man presenting with a brain abscess 13 weeks after a spontaneous ICH, without previous episodes of sepsis and with a suspected septic arthritis 2 weeks after abscess drainage.

Topics: Anti-Bacterial Agents; Brain Abscess; Cerebral Hemorrhage; Chemoradiotherapy; Drainage; Dysarthria; Headache; Hodgkin Disease; Humans; Hypertension; Levofloxacin; Magnetic Resonance Imaging; Male; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Nervous System Diseases; Oxacillin; Rifampin; Spine; Tomography, X-Ray Computed; Treatment Outcome

We report a male infant with congenital tuberculosis who developed cerebral hemorrhage associated with vitamin K deficiency during treatment with isoniazid and rifampin. Despite an absence of risk factors for vitamin K deficiency, the severe hemorrhagic disorder occurred at 4 months of age. We speculate that vitamin K deficiency in the present case may have resulted from a synergic effect of antituberculosis agents and immaturity of vitamin K metabolism and/or its absorption.

Topics: Cerebral Hemorrhage; Humans; Infant; Infectious Disease Transmission, Vertical; Isoniazid; Male; Rifampin; Streptomycin; Tuberculosis; Vitamin K; Vitamin K Deficiency

Topics: Adult; Cells, Cultured; Cerebral Hemorrhage; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Ethambutol; Female; Humans; Male; Purpura, Thrombocytopenic; Rifampin; Sputum; Time Factors; Tuberculosis, Pulmonary

Topics: Antibody Formation; Blood Cell Count; Blood Platelets; Cerebral Hemorrhage; Dyspnea; Ethambutol; Humans; Immunoglobulins; Liver Function Tests; Male; Middle Aged; Prednisone; Purpura, Thrombocytopenic; Rifampin; Tuberculosis, Pulmonary