rifampin has been researched along with Carcinoma--Squamous-Cell* in 7 studies
7 other study(ies) available for rifampin and Carcinoma--Squamous-Cell
Article | Year |
---|---|
Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis.
A total of forty-three compounds were synthesized, including thirty-two new ones. Among those compounds, seventeen were selected and tested on human tumor cell lines: PC-3 (prostate adenocarcinoma), HCT-116 (colorectal tumor), NCIH-460 (lung carcinoma), SKMEL-103 (melanoma) and AGP-01 (gastric tumor). Alkynylated 1,2,4-oxadiazoles 2m, 3g and 3k exhibited antiproliferative activities against NCIH-460 in culture. Alkynylated N-cyclohexyl-1,2,4-oxadiazoles 3a-m and bis-heterocycle glucoglycero-1,2,3-triazole-N-cyclohexyl-1,2,4-oxadiazole derivatives 5a-k and 6-11 were evaluated for their in vitro efficacy towards Mycobacterium tuberculosis (Mtb) H Topics: Alkynes; Animals; Antineoplastic Agents; Antitubercular Agents; Carcinoma, Squamous Cell; Cell Line; Cell Proliferation; Cell Survival; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Discovery; Glycoconjugates; Humans; Lung Neoplasms; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Structure-Activity Relationship; Triazoles | 2021 |
Minor role of pregnane-x-receptor for acquired multidrug resistance in head and neck squamous cell carcinoma in vitro.
Acquired multidrug resistance (MDR) has been linked to overexpression of drug-metabolising and transporting proteins mediated by pregnane-x-receptor (PXR). The aim of this work was to establish the relevance of PXR for MDR in head and neck squamous cell carcinoma (HNSCC).. Using eight HNSCC cell lines, we determined the efficacy of paclitaxel, cisplatin and 5-fluorouracil (5-FU) via proliferation assays and determined the expression and activity of PXR through quantitative real-time polymerase chain reaction, western blotting and luciferase-based reporter gene assay. PXR knockdown approaches using shRNA-encoding vectors were applied to estimate the role of PXR for native MDR.. Drug resistance ranged between 5.2 and 620 nM for paclitaxel, varied between 4.5 and 58 μM for cisplatin, and varied between 1.1 and 5,467 μM for 5-FU. Lack of PXR mRNA expression was mostly accompanied by the absence of mRNA expression of cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp, ABCB1) expression. Neither mRNA nor protein expression of PXR correlated with drug resistance. However, PXR activity tended to correlate with IC50 values of paclitaxel (p = 0.08). Knockdown of PXR in one of the cell lines had a slight but not significant impact on paclitaxel efficacy compared to scrambled sequence control. Surprisingly, only in two cell lines, PXR activity was increased by the well-known inductor rifampicin.. This study suggests a malfunctioning of PXR and thus a minor relevance for iatrogenic chemotherapy resistance in HNSCC. Topics: Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Head and Neck Neoplasms; Humans; Inhibitory Concentration 50; Paclitaxel; Pregnane X Receptor; Real-Time Polymerase Chain Reaction; Receptors, Steroid; Rifampin | 2013 |
BCG-induced lupus vulgaris complicated by squamous cell carcinoma in a 7-year-old child.
Topics: Antitubercular Agents; BCG Vaccine; Carcinoma, Squamous Cell; Child; Ethambutol; Humans; Isoniazid; Lupus Vulgaris; Lymphatic Metastasis; Male; Pyrazinamide; Rifampin; Skin Neoplasms; Treatment Outcome | 2011 |
Reduced intracellular activity of antibiotics against Listeria monocytogenes in multidrug resistant cells.
Multidrug resistance is expressed not only by bacteria, but also by tumor cells and by some normal cells of the body. It enables eukaryotic cells to exclude not only cytostatic drugs but also non-cytostatic antibiotics. This was demonstrated in genetically engineered multidrug resistant (MDR) cells infected with the facultative intracellular bacterium Listeria monocytogenes for all macrolide antibiotics tested (azithromycin, clarithromycin, erythromycin, josamycin, roxithromycin and spiramycin). In these cells and in conventionally selected MDR cells higher concentrations of the macrolides were necessary to inhibit the growth of L. monocytogenes than in the respective parental cells. This effect was due to a reduced intracellular accumulation, which was shown with a biological assay for all macrolides tested. For azithromycin, the results of this test were confirmed by measurement of the intracellular concentrations with high-performance liquid chromatography (HPLC). Besides the macrolides, MDR cells excluded also antibiotics of other chemical groups which was shown for ciprofloxacin, clindamycin, rifampicin and the streptogramin derivative RP 59500. In addition, in conventionally selected cells higher concentrations of chloramphenicol, doxycyclin, ofloxacin and trimethoprim than in the respective parental cells were necessary to inhibit the growth of L. monocytogenes. In contrast, when using genetically engineered cells, no significant differences were found for these antibiotics. These differences might be due to a higher expression of multidrug resistance in the conventionally selected cells because these cells were also more effective in excluding rhodamine 123 in a flow cytometric assay. In conclusion, expression of multidrug resistance by eukaryotic cells leads to a reduced concentration of macrolides and other antibiotics in these cells and to an impairment of activity against intracellular bacteria. Topics: Animals; Anti-Bacterial Agents; Carcinoma, Squamous Cell; Cell Line; Ciprofloxacin; Clindamycin; Drug Resistance, Microbial; Drug Resistance, Multiple; Fibroblasts; Genetic Engineering; Humans; Listeria monocytogenes; Mice; Rifampin; Virginiamycin | 1998 |
Rifampicin (Lepetit) and its effects on human cells cultured in vitro.
Topics: Carcinoma, Squamous Cell; Cell Line; Cells, Cultured; HeLa Cells; Humans; In Vitro Techniques; Laryngeal Neoplasms; Rifampin | 1974 |
The action of rifampicin on stabilized cell lines HEp-2 and HeLa.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cattle; Cell Line; Cell Nucleolus; Cells, Cultured; Chromosome Aberrations; Chromosomes; Culture Media; DNA-Directed RNA Polymerases; Female; HeLa Cells; Humans; Laryngeal Neoplasms; Mitosis; Rifampin; RNA, Neoplasm; Tritium; Uridine | 1974 |
[Virostatica and stages of cancerization of the collum uteri (author's transl)].
Topics: Adult; Carcinoma in Situ; Carcinoma, Squamous Cell; Colposcopy; Cytodiagnosis; Female; Humans; Rifampin; Uterine Cervical Neoplasms | 1973 |