rifampin and Bronchitis

A case is reported of hemolytic anemia following rifampicin administration and complicated by acute renal failure. Furthermore clotting analyses suggested a slight disseminated intravascular coagulation, very likely activated by hemolysis products. Both hemolysis and renal function impairment subsided spontaneously, after the sole withdrawal of rifampin. Direct antiglobulin test became negative within a few days, while an indirect Coomb's test was demonstrated persistently with the patient's serum using red blood cells sensitized in vitro with the drug. Otherwise from all reports in the literature, the patient developed an acute hemolytic anemia while on daily therapy and as many as twenty years after a previous treatment with rifampicin. Mechanisms of drug-induced immune hemolytic anemia and acute nephropathy are discussed (formation of drug-antibody complexes, which adhere on the red blood cells surface and are able to fix complement and induce intravascular hemolysis; tubular necrosis due to hemoglobinuria or immuno-mediated interstitial nephritis).

Topics: Acute Kidney Injury; Anemia, Hemolytic, Autoimmune; Bronchitis; Chronic Disease; Drug Therapy, Combination; Female; Humans; Middle Aged; Rifampin; Time Factors

Topics: Aminosalicylic Acids; Bronchitis; Cough; Diagnosis, Differential; Ethambutol; Humans; Isoniazid; Mass Screening; Rifampin; Streptomycin; Thioacetazone; Tuberculosis; Tuberculosis, Lymph Node; Tuberculosis, Pulmonary

Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antitubercular Agents; Bronchitis; Drug Resistance, Microbial; Drug Synergism; Ethambutol; Humans; Microbial Sensitivity Tests; Pneumonia; Respiratory Tract Infections; Rifampin; Tuberculosis, Pulmonary

Topics: Acute Disease; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aerosols; Asthma; Bronchitis; Chromones; Chronic Disease; Ethambutol; Humans; Mycoplasma Infections; Respiratory Insufficiency; Respiratory Tract Diseases; Respiratory Tract Infections; Rifampin; Tuberculosis; Tuberculosis, Pulmonary; Virus Diseases

Topics: Bacteriological Techniques; Bronchitis; Chronic Disease; Drug Resistance, Microbial; Haemophilus influenzae; Humans; Rifampin; Sputum; Streptococcus pneumoniae

Pulmonary involvement is a rare complication of brucellosis. We describe the largest series to date, to our knowledge, of patients with pulmonary brucellosis.. This 10-year, retrospective, descriptive study involved 27 centers in Turkey, including all patients with brucellosis with confirmed respiratory system involvement.. Of 133 patients (67 men), 123 (92.5%) had acute infection (defined as < 2 months), with an overall mean ± SD duration of symptoms of 33.9 ± 8.5 days. The radiologic pattern of pulmonary disease was consolidation/lobar pneumonia in 91 patients (68.4%) and pleural effusion in 41 patients (30.8%), including 30 (22.5%) with both. Moreover, 23 patients (17.3%) had bronchitis (one with coexistent pneumonia), and 10 (7.5%) had nodular lung lesions (one with coexistent pneumonia and effusion). Blood culture results were positive in 56 of 119 patients, and all other cases were serologically confirmed. None of 60 sputum specimens and two of 19 pleural fluid samples (10.5%) yielded positive culture results for brucellosis. Other features of brucellosis, such as osteoarticular complications, were detected in 61 patients (45.9%); 59 (44.4%) had raised liver transaminase levels, and 59 (44.4%) had thrombocytopenia. Fifteen patients (11.3%) required management in an ICU for an average of 3.8 ± 2.2 days. All patients responded to standard combination antimicrobial therapy for brucellosis with no deaths, although treatment regimens required modification in seven patients.. Brucellosis with pulmonary involvement is rare but has a good prognosis following treatment with appropriate antibiotics. Many clues in the exposure history, presenting clinical features, and baseline blood tests should alert the clinician to consider brucellosis.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bronchitis; Brucellosis; Ceftriaxone; Doxycycline; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pleural Effusion; Pneumonia; Prognosis; Retrospective Studies; Rifampin; Streptomycin; Turkey; Young Adult

Topics: Antitubercular Agents; Bronchitis; Bronchoalveolar Lavage Fluid; Bronchoscopy; CD4-CD8 Ratio; Diagnosis, Differential; Diagnostic Errors; Drug Therapy, Combination; Ethambutol; Facial Dermatoses; Female; Humans; Isoniazid; Middle Aged; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Sarcoidosis; Sputum; Tuberculosis, Cutaneous; Tuberculosis, Pulmonary

We report two cases of brucellosis in members of a hunt club, both of whom had killed and dressed wild boars. Serologic studies usually suffice for screening patients with suspected or possible brucellosis; however, and as illustrated by our index case, one should ask the laboratory to dilute serum out beyond the customary 1:160 titer if results are negative yet the clinical suspicion high. Hunters should be advised to wear gloves prior to dressing wild mammals.

Topics: Adult; Animals; Anti-Bacterial Agents; Bronchitis; Brucella abortus; Brucellosis; Diagnosis, Differential; Doxycycline; Enzyme Inhibitors; Firearms; Humans; Male; Rifampin; South Carolina; Sus scrofa; Titrimetry

Rifametoprim (600 mg/day) was given to 64 patients with acute bacterial pneumonia, acute bronchitis and exacerbation of chronic bronchitis. 201 (83.4%) out of 241 isolates were sensitive to the action of the antibiotic. The treatment turned out effective in 84.4% of cases.

Topics: Acute Disease; Bacteria; Bronchitis; Capsules; Chronic Disease; Drug Combinations; Drug Evaluation; Humans; Microbial Sensitivity Tests; Pneumonia; Remission Induction; Rifampin; Sputum; Trimethoprim

The efficacy of treatment with rifampicin-dimexide++ aerosols of 184 pulmonary tuberculosis patients and 18 chronic obstructive bronchitis patients was studied. The character of the residual changes following the main chemotherapeutic course was studied in 98 patients. Dimexide++ was proved to be a good rifampicin solvent and synergist enhancing its bacteriostatic action. Rifampicin used in a dose of 150-300 mg in 3-4 ml of dimexide++ in aerosols for 1-2 months promotes bacillary excretion cessation and healing of destruction cavities and allows for a reduction of its toxic action on liver parenchyma. Rifampicin--dimexide++ aerosols contribute to more complete tuberculosis cure and reduce the residual pulmonary and bronchial changes. Rifampicin with dimexide++ can be successfully used for treating chronic bronchitis both as an independent disease and concurrent disease in pulmonary tuberculosis.

Topics: Administration, Inhalation; Adolescent; Adult; Aged; Bronchitis; Chronic Disease; Dimethyl Sulfoxide; Drug Combinations; Drug Synergism; Female; Humans; Male; Middle Aged; Rifampin; Tuberculosis, Pulmonary

Topics: Adult; Bronchitis; Chronic Disease; Drug Interactions; Drug Therapy, Combination; Dyphylline; Erythromycin; Humans; Lincomycin; Male; Middle Aged; Rifampin; Theophylline

Topics: Adolescent; Adult; Aged; Bronchitis; Chronic Disease; Drug Evaluation; Female; Humans; Male; Middle Aged; Pulmonary Heart Disease; Rifampin; Streptomycin; Time Factors

Topics: Bronchitis; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Isoniazid; Male; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Rifampin; Tuberculosis, Pulmonary

Topics: Adult; Asthma; Bromhexine; Bronchitis; Humans; Male; Middle Aged; Rifampin; Sputum

Topics: Aged; Aminosalicylic Acids; Antitubercular Agents; Arthritis, Rheumatoid; Bronchitis; Diabetes Complications; Drug Therapy, Combination; England; Female; Humans; Male; Mass Chest X-Ray; Mycobacterium tuberculosis; Nose; Occupations; Pneumoconiosis; Pulmonary Emphysema; Rifampin; Silicotuberculosis; Sputum; Streptomycin; Tuberculosis, Miliary; Tuberculosis, Pulmonary

Topics: Bronchitis; Humans; Rifampin

Topics: Adolescent; Adult; Aged; Bronchitis; Bronchopneumonia; Enterobacteriaceae; Feeding and Eating Disorders; Female; Haemophilus influenzae; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Nausea; Neoplasm Metastasis; Pleural Neoplasms; Pleurisy; Pleuropneumonia; Pneumonia, Pneumococcal; Pulmonary Emphysema; Rifampin; Sputum; Staphylococcus

Topics: Adrenal Cortex Hormones; Bronchitis; Humans; Isoniazid; Male; Middle Aged; Prognosis; Rifampin; Spondylitis; Streptomycin; Tuberculosis, Pulmonary; Tuberculosis, Spinal

Topics: Bronchitis; Chronic Disease; Humans; Rifampin; Sputum

Topics: Acute Disease; Bacteria; Blood Proteins; Bronchitis; Drug Resistance, Microbial; Enterococcus faecalis; Escherichia coli; Haemophilus influenzae; Humans; Klebsiella; Neisseria; Protein Binding; Proteus; Pseudomonas aeruginosa; Rifampin; Sputum; Staphylococcus; Streptococcus; Streptococcus pneumoniae

Topics: Bronchitis; Chronic Disease; Drug Resistance, Microbial; Drug Synergism; Economics, Medical; Ethambutol; Humans; Isoniazid; Rifampin; Tuberculosis

Topics: Adult; Aged; Bronchiectasis; Bronchitis; Chronic Disease; Endocarditis, Bacterial; Female; Humans; Male; Middle Aged; Osteomyelitis; Rifampin

Topics: Adult; Bronchiectasis; Bronchitis; Bronchopneumonia; Humans; Lung Abscess; Male; Middle Aged; Rifampin

Topics: Acute Disease; Bronchitis; Bronchopneumonia; Humans; Lung Abscess; Pneumonia, Pneumococcal; Rifampin

Topics: Adolescent; Adult; Bacteria; Bronchitis; Bronchopneumonia; Child; Female; Humans; Lung Abscess; Male; Middle Aged; Pleuropneumonia; Pneumonia; Rifampin

Topics: Antitubercular Agents; Bronchitis; Cycloserine; Humans; Italy; Lung Diseases; Lung Neoplasms; Pyrazines; Rifampin; Tuberculosis; Tuberculosis, Pulmonary