rifampin and Breast-Diseases

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Biopsy, Needle; Breast; Breast Diseases; Drug Therapy, Combination; Female; Granuloma, Plasma Cell; Humans; Immunohistochemistry; Mammography; Middle Aged; Prednisone; Rifampin; Ultrasonography, Mammary

A 60-year-old woman presented with a painful lump of 4 months duration in her right breast. She denied any history of breast trauma or family history of breast cancer. Physical examination detected a firm, tender mass in the upper inner quadrant of her right breast without an associated sinus tract. Cytology from fine-needle aspiration of the swelling showed epithelioid cells, lymphohistocytic aggregates, and necrosis. Diagnosis was confirmed by the identification of acid-fast bacilli in tissue sections using Ziehl-Neelsen staining.

Topics: Antitubercular Agents; Biopsy, Fine-Needle; Breast Diseases; Ethambutol; Female; Humans; Isoniazid; Middle Aged; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Tuberculosis

We report a case of group B streptococcal septicemia of digestive origin with secondary bilateral breast dermal-hypodermal localization.. A 71 year-old woman with a past history of bilateral breast cancer treated by conservation therapy was hospitalized because of the sudden occurrence of two clearly delimited, inflammatory, dermal-hypodermal cutaneous plaques located on each breast, associated with fever (39 degrees C), 4 days after a colonoscopy. Further investigations eliminated carcinomatous mastitis and blood cultures were positive for group B beta-hemolytic streptococcus (Streptococcus agalactiae). Histological examination of a sigmoid polyp revealed a tubular adenocarcinoma.. We report the first documented case of secondary dermal-hypodermal bacterial skin infection (cellulitis) due to group B beta-hemolytic streptococcus. The occurrence after colonoscopy examination, chronology of clinical features, bilaterality and positive blood cultures are arguments in favor of the secondary nature of the skin infection process.

Topics: Adenocarcinoma; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Breast Diseases; Cellulitis; Clavulanic Acid; Colonic Polyps; Colonoscopy; Drug Therapy, Combination; Female; Humans; Metronidazole; Rifampin; Sepsis; Sigmoid Neoplasms; Streptococcal Infections; Streptococcus agalactiae; Time Factors; Treatment Outcome

The authors report a case of tuberculosis of the breast in a patient aged 71. The case described is an example of a rare form of extra pulmonary tuberculosis whose diagnosis can pose problems. In view of the recent increase in the incidence of tuberculosis in certain developed countries and the growth in the proportion of cases of extra pulmonary tuberculosis especially in HIV sero-positive individuals an observation such as this is useful in that it recalls for clinicians the fact that tuberculosis may present in very unusual forms which are easily forgotten.

Topics: Abscess; Aged; Antibiotics, Antitubercular; Antitubercular Agents; Breast Diseases; Female; Follow-Up Studies; Humans; Isoniazid; Mammography; Prognosis; Radiography, Thoracic; Rifampin; Time Factors; Tomography, X-Ray Computed; Tuberculosis