rifampin and Abortion--Spontaneous

Brucellosis zoonotic infection caused by Brucella spp. In endemic countries, the disease does not spare the pregnant. There is evidence that brucellosis can induce abortion in humans. Positive cultures of brucella from human placenta, aborted fetuses, and other products of conception were reported previously. It is speculated that brucellosis causes fewer spontaneous abortions in humans than animals due to the absence of Erythritol in the human placenta and fetus. In addition, the presence of anti-brucella activity in human amniotic fluid may also play a role. Rifampin is considered the mainstay of treatment of brucellosis during pregnancy, in various combinations. In a retrospective study of brucellosis in pregnancy, antepartum treatment with antimicrobial agents was more protective against the occurrence of abortion than no or inadequate treatment. It seems that the incidence of abortion is not different among patients treated with either trimethoprim-sulfamethoxazole with or without rifampicin. With therapy during pregnancy, the overall success rate resulting in normal delivery is 90%. The article discussed few of the patents associated with brucellosis.

Topics: Abortion, Spontaneous; Anti-Infective Agents; Brucellosis; Female; Humans; Patents as Topic; Pregnancy; Pregnancy Complications, Infectious; Rifampin; Trimethoprim, Sulfamethoxazole Drug Combination

At the present time there is no medicament completely harmless to the embryo or fetus. Passage through the placenta probably occurs by simple diffusion. Substances with a molecular weight under 600, low protein binding, a low degree of ionization and good solubility in lipids cross the placenta most easily. The harmful effects of the different groups of medicaments are describedand the substances classified into those not particularly toxic, those which can only be used in certain conditions and those only to be used in exceptional cases. The treatment of the most common infections in pregnancy is dealth with in detail. Infections of the maternal urinary tract and amnionitis raise most problems. For the treatment of amnionitis, direct instillation of the medicament into the amniotic sac is recommended.

Topics: Abortion, Spontaneous; Antimalarials; Antiviral Agents; Central Nervous System; Cephalosporins; DNA Replication; Female; Humans; Isoniazid; Maternal-Fetal Exchange; Methemoglobinemia; Molecular Weight; Nalidixic Acid; Pregnancy; Pregnancy Complications, Infectious; Protein Binding; Rifampin; Sulfonamides; Teratogens; Urinary Tract Infections

Brucellosis is a worldwide zoonotic disease caused by Brucella spp. Brucella invades the body through the skin mucosa, digestive tract, and respiratory tract. However, only a few studies on human spontaneous abortion attributable to Brucella have been reported. In this work, the patient living in Shanxi Province in China who had suffered a spontaneous abortion was underwent pathogen detection and Brucella melitensis biovar 3 was identified.. The patient in this study was 22 years old. On July 16, 2015, she was admitted to Shanxi Grand Hospital, Shanxi Province, China because of one day of vaginal bleeding and three days of abdominal distension accompanied by fever after five months of amenorrhea. A serum tube agglutination test for brucellosis and blood culture were positive. At the time of discharge, she was prescribed oral doxycycline (100 mg/dose, twice a day) and rifampicin (600 mg/dose, once daily) for 6 weeks as recommended by the World Health Organization (WHO). No recurrence was observed during the six months of follow-up after the cessation of antibiotic treatment.. This is the first reported case of miscarriage resulting from Brucella melitensis biovar 3 isolated from a pregnant woman who was infected through unpasteurized milk in China. Brucellosis infection was overlooked in the Maternity Hospital because of physician unawareness. Early recognition and prompt treatment of brucellosis infection are crucial for a successful outcome in pregnancy.

Topics: Abortion, Spontaneous; Animals; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; China; Doxycycline; Female; Humans; Pregnancy; Rifampin; Treatment Outcome; Young Adult

From April 2000 to March 2010, 19 pregnant women with brucellosis were evaluated, treated and followed up. Ten (53%) pregnant women had spontaneous abortions. Six of eleven (55%) women infected in the first trimester had a spontaneous abortion. After treatment, all subsequently became pregnant and gave birth to normal babies. Among 13 patients who received cotrimoxazole plus rifampin, only four (31%) aborted and nine mothers had normal term deliveries. Two patients with recurrent abortions had brucellosis and became pregnant and gave birth after treatment. The brucellosis screening program for pregnant women and those with spontaneous abortion is necessary in brucellosis endemic regions.

Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Infective Agents; Brucellosis; Drug Therapy, Combination; Female; Humans; Iran; Mass Screening; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Rifampin; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Young Adult

Brucellosis is a worldwide zoonotic gram-negative bacterium of worldwide distribution. Its role in causing miscarriage in animals is well documented. Data on its role in human abortion are very few. This paper was carried out on selected women with abortion or history of abortion to clarify the role of brucellosis in human abortion. A total of 129 women were selected from Al-Zahraa University Hospital and other obstetric and gynecological hospitals in the vicinity of Greater Cairo. The patients were subjected to clinical, gynecological, and serodiagnosis (STAT and ELISA) of brucellosis. Also, routine urine (Nuclepore technique) and stool (Kato thick smear) was done as well as skin tests and ELISA for common hepatic parasites. The results showed that 59 had brucellosis, 27 had toxoplasmosis, 15 had fascioliasis and 29 had other cause(s) of abortion. Meanwhile, none had visceral leishmaniasis or schistosomiasis mansoni. the signs and symptoms of all patients were hepatosplenomegaly (31.1%), lower back abdominal pain (23.13%), lassitude, headache (each, 21.7%), lymphadenopathy (20.1%), vomiting (17.1%), loss of appetite, myalgia or diarrhea or constipation (each, 15.42 %), weight loss (14.6%), chest pain (13.9%), night sweating or dizziness (11.65%), fever or right sided abdominal pain (each, 10.7%), chills (7.71%), urticaria or monoarthralgia (each, 3.85%). These signs and symptoms were confusing for specific clinical picture of brucellosis. Brucellosis patients were successfully treated with a combination of Rifampicin 600 mg. once daily and Septrin 800 mg twice daily for 6 weeks. Cure was achieved clinically and serologically. Patients with toxoplasmosis or fascioliasis were also treated with Fasinex and Mirazid respectively. Other parasites were also treated.

Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Bacterial Agents; Brucellosis; Female; Humans; Infectious Disease Transmission, Vertical; Middle Aged; Pregnancy; Pregnancy Complications, Infectious; Rifampin; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination; Young Adult

Topics: Abortion, Spontaneous; Adult; Antitubercular Agents; Clarithromycin; Diagnosis, Differential; Female; Genital Diseases, Female; Humans; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Pregnancy; Rifampin

Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Female; Fetal Death; Hemorrhagic Disorders; Humans; Infant; Infant, Newborn; Pregnancy; Rabbits; Rats; Rifampin; Teratogens

Topics: Abortion, Spontaneous; Adolescent; Adult; Aged; Female; Genital Diseases, Female; Genital Neoplasms, Female; Humans; Mastitis; Middle Aged; Postoperative Care; Pregnancy; Pregnancy Complications, Infectious; Preoperative Care; Puerperal Infection; Pyelitis; Rifampin