rifabutin and Sepsis

rifabutin has been researched along with Sepsis* in 1 studies

Other Studies

1 other study(ies) available for rifabutin and Sepsis

Article	Year
Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins. Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5 A novel series of spirorifamycins was synthesized and their antibacterial activity evaluated both in vitro and in vivo. This new series of rifamycins shows excellent activity against Staphylococcus aureus that is equivalent to rifabutin. However, some compounds of the series exhibit lower MICs than rifabutin against rifampin-resistant strains of S. aureus. Further, compound 2e exhibits comparable efficacy in vivo in a murine model of S. aureus septicemia model following administration by either oral or parenteral dosing routes. Topics: Animals; Anti-Bacterial Agents; Drug Administration Routes; Mice; Microbial Sensitivity Tests; Rifabutin; Rifamycins; Sepsis; Staphylococcus aureus; Structure-Activity Relationship	2007

Article

Year

Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins.

Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5

A novel series of spirorifamycins was synthesized and their antibacterial activity evaluated both in vitro and in vivo. This new series of rifamycins shows excellent activity against Staphylococcus aureus that is equivalent to rifabutin. However, some compounds of the series exhibit lower MICs than rifabutin against rifampin-resistant strains of S. aureus. Further, compound 2e exhibits comparable efficacy in vivo in a murine model of S. aureus septicemia model following administration by either oral or parenteral dosing routes.

Topics: Animals; Anti-Bacterial Agents; Drug Administration Routes; Mice; Microbial Sensitivity Tests; Rifabutin; Rifamycins; Sepsis; Staphylococcus aureus; Structure-Activity Relationship

2007