rhyncophylline and Thrombophlebitis

rhyncophylline has been researched along with Thrombophlebitis* in 1 studies

Other Studies

1 other study(ies) available for rhyncophylline and Thrombophlebitis

Article	Year
Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:2 Rhynchophylline (Rhy) inhibited rabbit platelet aggregation induced by arachidonic acid (AA), collagen, and ADP. The values of IC50 were 0.72, 0.74, and 0.67 mmol.L-1, respectively. Rhy reduced the thromboxane B2 (TXB2) generation in PRP induced by collagen but failed to reduce that induced by AA. Rhy suppressed malondialdehyde (MDA) formation in platelet suspension stimulated by thrombin, inhibited the platelet factor 4 (PF4) release. It did not alter intraplatelet cAMP concentration. Rhy 10-20 mg.kg-1 iv showed a significant inhibition of venous thrombosis and cerebral thrombosis in rats. Topics: Alkaloids; Animals; Cyclic AMP; Indole Alkaloids; Intracranial Embolism and Thrombosis; Male; Malondialdehyde; Oxindoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 4; Rabbits; Rats; Rats, Inbred Strains; Thrombophlebitis; Thromboxane B2	1992

Article

Year

Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:2

Rhynchophylline (Rhy) inhibited rabbit platelet aggregation induced by arachidonic acid (AA), collagen, and ADP. The values of IC50 were 0.72, 0.74, and 0.67 mmol.L-1, respectively. Rhy reduced the thromboxane B2 (TXB2) generation in PRP induced by collagen but failed to reduce that induced by AA. Rhy suppressed malondialdehyde (MDA) formation in platelet suspension stimulated by thrombin, inhibited the platelet factor 4 (PF4) release. It did not alter intraplatelet cAMP concentration. Rhy 10-20 mg.kg-1 iv showed a significant inhibition of venous thrombosis and cerebral thrombosis in rats.

Topics: Alkaloids; Animals; Cyclic AMP; Indole Alkaloids; Intracranial Embolism and Thrombosis; Male; Malondialdehyde; Oxindoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 4; Rabbits; Rats; Rats, Inbred Strains; Thrombophlebitis; Thromboxane B2

1992