rhodanine and Tauopathies

rhodanine has been researched along with Tauopathies* in 2 studies

Other Studies

2 other study(ies) available for rhodanine and Tauopathies

Article	Year
Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains. ACS chemical neuroscience, 2011, May-18, Volume: 2, Issue:5 A novel series of rhodanin (RH) and thiohydantoin (TH) derivatives were designed and synthesized for detecting tau pathology in the brains of patients with Alzheimer's disease (AD). In experiments in vitro using tau and β-amyloid (Aβ) aggregates, the TH derivative, TH2, showed high specific binding to tau aggregates. In hippocampal sections obtained from AD patients, TH2 intensely stained neurofibrillary tangles. In experiments using normal mice, [(125)I]TH2 showed good uptake (1.54%ID/g, 2 min postinjection) into and a rapid washout (0.25%ID/g, 60 min postinjection) from the brain. [(123)I]TH2 should be further investigated as a potential imaging agent for detecting tau pathology. Topics: Alzheimer Disease; Animals; Autoradiography; Benzothiazoles; Brain; Humans; Iodine Radioisotopes; Mice; Neurofibrillary Tangles; Positron-Emission Tomography; Radiopharmaceuticals; Recombinant Proteins; Rhodanine; Tauopathies; Thiazoles; Thiohydantoins; Tissue Distribution	2011
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:48 Topics: Animals; Cell Line, Tumor; Mice; Rhodanine; Structure-Activity Relationship; tau Proteins; Tauopathies	2007

Article

Year

Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains.

ACS chemical neuroscience, 2011, May-18, Volume: 2, Issue:5

A novel series of rhodanin (RH) and thiohydantoin (TH) derivatives were designed and synthesized for detecting tau pathology in the brains of patients with Alzheimer's disease (AD). In experiments in vitro using tau and β-amyloid (Aβ) aggregates, the TH derivative, TH2, showed high specific binding to tau aggregates. In hippocampal sections obtained from AD patients, TH2 intensely stained neurofibrillary tangles. In experiments using normal mice, [(125)I]TH2 showed good uptake (1.54%ID/g, 2 min postinjection) into and a rapid washout (0.25%ID/g, 60 min postinjection) from the brain. [(123)I]TH2 should be further investigated as a potential imaging agent for detecting tau pathology.

Topics: Alzheimer Disease; Animals; Autoradiography; Benzothiazoles; Brain; Humans; Iodine Radioisotopes; Mice; Neurofibrillary Tangles; Positron-Emission Tomography; Radiopharmaceuticals; Recombinant Proteins; Rhodanine; Tauopathies; Thiazoles; Thiohydantoins; Tissue Distribution

2011

Rhodanine-based tau aggregation inhibitors in cell models of tauopathy.

Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:48

Topics: Animals; Cell Line, Tumor; Mice; Rhodanine; Structure-Activity Relationship; tau Proteins; Tauopathies

2007