rhodanine and Lung-Neoplasms

A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared Ce6/Epa nanoparticles prevented BLBC metastasis effectively in vivo, providing a very promising two-pronged strategy against BLBC metastasis.

Topics: Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Chlorophyllides; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Humans; Lung Neoplasms; Mice; Mice, SCID; Nanoparticles; Photochemotherapy; Porphyrins; Radiation-Sensitizing Agents; Rhodanine; Thiazolidines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays