rhizoxin and Spinal-Neoplasms

rhizoxin has been researched along with Spinal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for rhizoxin and Spinal-Neoplasms

Article	Year
Inhibition of angiogenesis by rhizoxin, a microbial metabolite containing two epoxide groups. Japanese journal of cancer research : Gann, 1997, Volume: 88, Issue:12 Previous studies by our and other groups have shown that microbial products containing more than one epoxide group, including eponemycin, radicicol, depudecin and AGM-1470, exhibits anti-angio-genic activity in an in vivo assay system involving chorioallantoic membranes (CAMs) of growing chick embryos. Based on these findings, rhizoxin, a microbial metabolite that contains two epoxide groups and exhibits anti-tubulin activity, was tested for anti-angiogenic activity in a CAM assay system. Rhizoxin caused dose-dependent inhibition of embryonic angiogenesis, the ID50 value being 2 ng (3.2 pmol) per egg. In addition, this compound (2 mg/kg i.p.) significantly suppressed neovascularization induced by M5076 mouse tumor cells in a mouse dorsal air sac assay system, compared to the vehicle alone (P < 0.05). These results indicate that rhizoxin is a novel inhibitor of angiogenesis, and that is has potential as a new therapeutic agent for cancer. Topics: Animals; Antibiotics, Antineoplastic; Chick Embryo; Dose-Response Relationship, Drug; Epoxy Compounds; Lactones; Macrolides; Mice; Neovascularization, Pathologic; Neovascularization, Physiologic; Spinal Neoplasms; Spinal Nerve Roots	1997

Article

Year

Inhibition of angiogenesis by rhizoxin, a microbial metabolite containing two epoxide groups.

Japanese journal of cancer research : Gann, 1997, Volume: 88, Issue:12

Previous studies by our and other groups have shown that microbial products containing more than one epoxide group, including eponemycin, radicicol, depudecin and AGM-1470, exhibits anti-angio-genic activity in an in vivo assay system involving chorioallantoic membranes (CAMs) of growing chick embryos. Based on these findings, rhizoxin, a microbial metabolite that contains two epoxide groups and exhibits anti-tubulin activity, was tested for anti-angiogenic activity in a CAM assay system. Rhizoxin caused dose-dependent inhibition of embryonic angiogenesis, the ID50 value being 2 ng (3.2 pmol) per egg. In addition, this compound (2 mg/kg i.p.) significantly suppressed neovascularization induced by M5076 mouse tumor cells in a mouse dorsal air sac assay system, compared to the vehicle alone (P < 0.05). These results indicate that rhizoxin is a novel inhibitor of angiogenesis, and that is has potential as a new therapeutic agent for cancer.

Topics: Animals; Antibiotics, Antineoplastic; Chick Embryo; Dose-Response Relationship, Drug; Epoxy Compounds; Lactones; Macrolides; Mice; Neovascularization, Pathologic; Neovascularization, Physiologic; Spinal Neoplasms; Spinal Nerve Roots

1997