rhizoxin and Carcinoma--Squamous-Cell

rhizoxin has been researched along with Carcinoma--Squamous-Cell* in 1 studies

Trials

1 trial(s) available for rhizoxin and Carcinoma--Squamous-Cell

ArticleYear
Phase II study of rhizoxin in squamous cell head and neck cancer. The EORTC Early Clinical Trials Group.
    British journal of cancer, 1996, Volume: 73, Issue:3

    To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < or = 2 and organ functions were normal. Treatment consisted of rhizoxin 1.5-2.0 mg m-2 i.v. bolus injection once every 3 weeks. Thirty-two patients entered the study. All were eligible, 31 were evaluable for toxicity and 25 for response. Toxicity mainly consisted of pain at the tumour site and leucocytopenia. Mild asthenia and stomatitis were also observed. Two objective partial responses, lasting 7.5 and 3.5 months, were seen. Rhizoxin at this dose and schedule has minor activity in recurrent and/or metastatic squamous cell head and neck cancer.

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Lactones; Macrolides; Male; Middle Aged

1996