rhein has been researched along with Innate Inflammatory Response in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 11 (47.83) | 24.3611 |
| 2020's | 10 (43.48) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J | 1 |
| Gao, P; Hao, X; Liu, X; Xu, H; Zhan, P; Zou, J | 1 |
| Gu, H; Ji, L | 1 |
| Alalaiwe, A; Chuang, SY; Fang, JY; Huang, TH; Lin, CF; Nguyen, TMH; Wang, PW | 1 |
| Junfang, F; Ou, C; Yibiao, W | 1 |
| Cao, Q; Chen, X; Chen, Y; Liu, C; Wei, W; Zhang, Z; Zhu, Y | 1 |
| Liu, J; Peng, S; Xu, H; Xu, T; Yang, Z; Zhang, W; Zhang, Z; Zhao, L; Zhu, Y | 1 |
| Chai, P; Chen, H; Dong, Y; He, X; Hu, Z; Jiang, Y; Ma, G; Wei, Q; Wu, Q; Zhang, W; Zhao, J | 1 |
| Chen, D; Du, S; Lau, N; Li, C; Li, H; Liu, X; Mei, L; Miao, J; Wen, Q; Weng, H; Xu, Q; Ye, P; Zhang, C; Zhang, F | 1 |
| Hu, J; Wang, D; Wu, H; Yang, Z | 1 |
| Chen, J; Jiang, Y; Lei, G; Liu, M; Liu, S; Pei, R | 1 |
| Cui, J; Gao, K; Jia, Y; Liu, M; Peng, L; Wang, F; Wang, J; Wang, L; Wen, A; Wu, X; Zhao, J | 1 |
| Ge, H; Liang, Y; Ma, Z; Tang, H; Wu, J; Yang, Q; Zeng, L | 1 |
| Bian, Y; Chen, Q; Fan, Y; Liu, P; Liu, Z; Zhong, J; Zhuang, S | 1 |
| Liu, P; Liu, Z; Zhong, J; Zhong, Y; Zhou, Q; Zhuang, S | 1 |
| Dang, L; Fan, R; Gan, P; Liu, J; Ran, L; Sun, Z; Tang, T; Wang, Y; Wu, H; Yan, Y; Yang, T; Yao, H; Yi, L; Zhang, Y; Zheng, J; Zheng, P | 1 |
| Hu, G; Lin, YJ; Liu, J; Qiao, Y; Tu, P; Wei, J; Zhen, YZ | 1 |
| Cai, R; Chen, X; Fang, L; Gao, Y; Liu, F; Peng, C; Qi, Y | 1 |
| Li, J; Li, JY; Ren, HY; Su, H; Tang, WF; Wu, FS; Zhang, YM; Zhao, XL | 1 |
| Bianchi, A; Deffaud, J; Domagala, F; Ficheux, H; Jouzeau, JY; Kirchmeyer, M; Netter, P | 1 |
| Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y | 2 |
| Annunziata, S; Ciccimarra, F; Londei, M; Maiuri, L; Raimondi, F; Rubino, A; Santoro, P | 1 |
2 review(s) available for rhein and Innate Inflammatory Response
| Article | Year |
|---|---|
Recent progress in the structural modification and pharmacological activities of ligustrazine derivatives.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Bacteria; Cardiovascular Diseases; Humans; Inflammation; Molecular Structure; Neoplasms; Neuroprotective Agents; Pyrazines | 2018 |
Rhein Derivatives, A Promising Pivot?
Topics: Animals; Anthraquinones; Arthritis; Cell Line, Tumor; Chemistry, Pharmaceutical; Diabetic Nephropathies; Drug Design; Humans; Inflammation; Inhibitory Concentration 50; Neoplasms | 2021 |
21 other study(ies) available for rhein and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |
The anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and oxidative stress in vivo and vitro.
Topics: 3T3-L1 Cells; Animals; Anthraquinones; Anti-Obesity Agents; Diet, High-Fat; Endoplasmic Reticulum Stress; Female; Inflammation; Insulin Resistance; Lipids; Mice; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2021 |
A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency.
Topics: Administration, Topical; Animals; Anthraquinones; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Emodin; HaCaT Cells; Humans; Imiquimod; Inflammation; Keratinocytes; Macrophages; Mice; Psoriasis; Rheum; Skin Absorption; Swine | 2022 |
Anti-inflammatory mechanism of rhein in treating asthma based on network pharmacology.
Topics: Anthraquinones; Anti-Inflammatory Agents; Asthma; Drugs, Chinese Herbal; ErbB Receptors; Humans; Inflammation; Mitogen-Activated Protein Kinase 14; Network Pharmacology; NF-kappa B | 2022 |
Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway.
Topics: AMP-Activated Protein Kinases; Anthraquinones; Ependymoglial Cells; Glucose; Humans; Inflammation; Oxidative Stress; Sirtuin 1 | 2023 |
Retinal Microenvironment-Protected Rhein-GFFYE Nanofibers Attenuate Retinal Ischemia-Reperfusion Injury via Inhibiting Oxidative Stress and Regulating Microglial/Macrophage M1/M2 Polarization.
Topics: Animals; Biological Products; Eye Diseases; Inflammation; Ischemia; Macrophages; Microglia; Nanofibers; Oxidative Stress; Peptides; Phosphatidylinositol 3-Kinases; Rats; Reperfusion Injury | 2023 |
Body temperature-induced adhesive hyaluronate/gelatin-based hybrid hydrogel dressing for promoting skin regeneration.
Topics: Adhesives; Animals; Anti-Bacterial Agents; Bandages; Body Temperature; Gelatin; Hydrogels; Inflammation; Mice; Silver | 2023 |
Rhein attenuates lipopolysaccharide-primed inflammation through NF-κB inhibition in RAW264.7 cells: targeting the PPAR-γ signal pathway.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Cell Survival; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Mice; NF-kappa B; PPAR gamma; RAW 264.7 Cells; Signal Transduction | 2020 |
Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cell Proliferation; Cyclooxygenase 2; Inflammation; Interleukin-1beta; Interleukin-6; Kidney Diseases; Mice; MicroRNAs; RNA, Long Noncoding; STAT1 Transcription Factor; Tumor Necrosis Factor-alpha; Uric Acid | 2020 |
Rhein protects 5/6 nephrectomized rat against renal injury by reducing inflammation via NF-κB signaling.
Topics: Animals; Anthraquinones; Enzyme Inhibitors; Inflammation; Male; Nephrectomy; NF-kappa B; Postoperative Complications; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Signal Transduction | 2021 |
Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro.
Topics: Adenosine Triphosphate; Animals; Animals, Genetically Modified; Anthraquinones; Anti-Inflammatory Agents; Cell Movement; Cyclooxygenase 2; Dose-Response Relationship, Drug; Inflammasomes; Inflammation; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphorylation; RAW 264.7 Cells; Signal Transduction; Transcription Factor RelA; Zebrafish | 2017 |
Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Inflammation; Interleukin-1beta; Intestinal Mucosa; Intestine, Small; Lipopolysaccharides; Male; Malondialdehyde; MAP Kinase Signaling System; NF-E2-Related Factor 2; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2019 |
Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Cell Line; Inflammation; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Lipopolysaccharides; NF-kappa B; Rats; Rheum; Signal Transduction; Tight Junctions; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein | 2019 |
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Cell Line; Delayed-Action Preparations; Drug Carriers; Drug Evaluation, Preclinical; Drug Liberation; Hydrogels; Inflammation; Lipopolysaccharides; Mice; Microglia; Microscopy, Electron, Scanning; Nanofibers; NF-KappaB Inhibitor alpha; Phosphorylation; Phytochemicals; Rheum; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA | 2019 |
Rhein inhibits the expression of vascular cell adhesion molecule 1 in human umbilical vein endothelial cells with or without lipopolysaccharide stimulation.
Topics: Anthraquinones; Anti-Inflammatory Agents; Atherosclerosis; Cell Line; E-Selectin; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Phytotherapy; Plant Extracts; Rheum; Vascular Cell Adhesion Molecule-1 | 2013 |
Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages.
Topics: Animals; Anthraquinones; Blotting, Western; Enzyme Inhibitors; I-kappa B Kinase; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Transfection | 2014 |
Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis.
Topics: Acute Disease; Alanine Transaminase; Animals; Anthraquinones; Aspartate Aminotransferases; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Emodin; Flavanones; Hesperidin; Inflammation; Lignans; Liver; Male; Pancreatitis; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2017 |
Modulatory effect of rhein on IL-1alpha-induced responses in human chondrocytes: a comparative study between antibody microarrays and specific ELISAs.
Topics: Anthraquinones; Antibodies; Cartilage, Articular; Chemokines; Chondrocytes; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Interleukin-1; Nitrites; Osteoarthritis; Protein Array Analysis | 2008 |
ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats.
Topics: Activating Transcription Factor 6; Adjuvants, Immunologic; Animals; Anthraquinones; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Edema; Endoplasmic Reticulum Stress; Female; Ibuprofen; Inflammation; Male; Matrix Metalloproteinase 2; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2012 |
Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein.
Topics: Activating Transcription Factor 6; Animals; Anthraquinones; Anti-Inflammatory Agents; Aquaporin 4; Arginine; Biomarkers; Carrageenan; Drug Combinations; Drugs, Chinese Herbal; Edema; Endoplasmic Reticulum Stress; Female; Indomethacin; Inflammation; Male; Matrix Metalloproteinase 2; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2012 |
Reactive nitrogen species modulate the effects of rhein, an active component of senna laxatives, on human epithelium in vitro.
Topics: Anthraquinones; Apoptosis; Caco-2 Cells; Cathartics; Chemotaxis, Leukocyte; Chlorides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Humans; Inflammation; Intestinal Mucosa; Kinetics; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Senna Extract | 2002 |