rhein has been researched along with Disease Models, Animal in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 19 (55.88) | 24.3611 |
| 2020's | 14 (41.18) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Aljuffali, IA; Chen, WJ; Fang, JY; Hsu, CY; Huang, TH | 1 |
| Alalaiwe, A; Chuang, SY; Fang, JY; Huang, TH; Lin, CF; Nguyen, TMH; Wang, PW | 1 |
| Abdallah, OY; Ebada, HMK; Nasra, MMA; Nassra, RA | 1 |
| Chen, Q; Dong, L; Du, H; Gao, F; Hu, Y; Luo, R; Pu, X; Tu, H; Wang, Y; Xu, H; Zhang, J; Zhang, M | 1 |
| Chen, KX; Dong, LL; DU, HL; Gao, F; Lin, MS; Zhong, HY | 1 |
| Gao, D; Gao, X; Lu, L; Luo, G; Ma, T; Wang, Y; Yin, Z; Zhang, Z | 1 |
| Chen, Y; Fu, S; Li, S; Mu, L; Xing, L | 1 |
| Chu, K; Han, L; Li, T; Ouyang, H; Qiu, L; Wang, X; Xu, W; Zhang, X | 1 |
| Duan, J; Guan, Y; Liu, M; Wang, J; Wei, G; Wu, X; Xi, M | 1 |
| Feng, F; Li, G; Shen, Y; Sun, H; Xiang, Z | 1 |
| Feng, Y; Gao, M; Jiang, C; Jin, Q; Ni, Y; Wu, T; Yin, Z; Zhang, D; Zhang, J; Zhang, L | 1 |
| Huang, W; Li, Y; Liu, H; Mai, G | 1 |
| Chen, Q; Deng, B; Dong, L; Fu, C; Fu, S; Gao, F; Lin, D; Lin, M; Luo, R; McDowell, A; Pu, X; Shi, J; Sun, J; Xu, H; Ye, N; Zhang, C; Zhang, J | 1 |
| Cao, J; Li, X; Yang, J; Yu, L; Yu, W | 1 |
| Fan, X; Feng, T; Fu, X; Qu, L; Shi, L; Wang, Y; Wei, S | 1 |
| Bi, F; Cao, W; Chen, F; Li, Y; Wei, A | 1 |
| Li, J; Peng, Y; Wan, D; Yang, Y; Zhang, J | 1 |
| Chen, D; Han, S; Hu, F; Wang, G; Wei, Y; Zhu, Y | 1 |
| Smith, ER | 1 |
| Bian, Y; Chen, Q; Fan, Y; Liu, P; Liu, Z; Zhong, J; Zhuang, S | 1 |
| Feng, SX; Li, JS; Li, RR; Liu, XF; Qu, LB; Shu, SN; Wang, PY; Zhang, N | 1 |
| Chen, G; Gong, H; Tang, W; Wang, J; Xiang, J; Zhao, J | 1 |
| Ding, X; Duan, P; Hu, G; Lin, YJ; Liu, J; Qiao, Y; Tu, P; Wu, HP; Xu, R | 1 |
| Chen, XW; Fu, AX; Peng, SN; Zeng, HH; Zhu, QX | 1 |
| Bian, DX; Chen, JY; Guo, JC; Liu, H; Liu, J; Liu, YL; Lu, L; Luo, Y; Shi, JP; Xun, YH; Yang, WJ; Zhuang, ZJ | 1 |
| Chang, LW; Hou, ML; Lin, CH; Lin, LC; Tsai, TH | 1 |
| Ding, G; Guo, C; Huang, W; Li, N; Meng, Z; Tang, Z; Wang, Z; Xiao, W; Yan, Y; Yang, Z | 1 |
| Fan, HY; Li, P; Qi, D; Sun, JF; Yu, C | 1 |
| Cao, W; Duan, A; Lin, W; Liu, L; Liu, Z; Yin, S; Zhang, Q | 1 |
| Fang, F; Jin, C; Kong, WJ; Wang, HJ; Wang, JB; Xiao, XH; Zhao, HP; Zhao, YL | 1 |
| DU, H; Gu, P; Liu, ZH; Shao, JQ; Wang, J | 1 |
| Chen, GY; Chen, WW; Tang, WF; Wan, MH; Xiang, J; Yu, Q; Zhao, XL | 1 |
| Ohmori, K; Tamura, T; Yokoyama, T | 1 |
34 other study(ies) available for rhein and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Animals; Anthraquinones; Anti-Obesity Agents; Cell Survival; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Emodin; Glycerol; Liver; Mice; Random Allocation; Rats; Rats, Sprague-Dawley; Rheum; Up-Regulation | 2022 |
A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency.
Topics: Administration, Topical; Animals; Anthraquinones; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Emodin; HaCaT Cells; Humans; Imiquimod; Inflammation; Keratinocytes; Macrophages; Mice; Psoriasis; Rheum; Skin Absorption; Swine | 2022 |
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment.
Topics: Animals; Anthraquinones; Cartilage, Articular; Chemistry, Pharmaceutical; Chondroitin Sulfates; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Lipids; Male; Nanoparticles; Osteoarthritis; Oxidative Stress; Particle Size; Random Allocation; Rats; Rats, Wistar; Surface Properties | 2022 |
Anti-inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2022 |
[Mechanism of combined treatment of rhein and emodin in Rhubarb for ulcerative colitis].
Topics: Animals; Anthraquinones; Colitis, Ulcerative; Colon; Disease Models, Animal; Emodin; Interleukin-6; Mice; Proto-Oncogene Proteins c-akt; Rheum; Tumor Necrosis Factor-alpha | 2022 |
Stepwise Coordination-Driven Metal-Phenolic Nanoparticle as a Neuroprotection Enhancer for Alzheimer's Disease Therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Mice; Mice, Transgenic; Molecular Docking Simulation; Nanoparticles; Neuroprotection | 2023 |
Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats.
Topics: Animals; Anthraquinones; Apoptosis; Disease Models, Animal; Disease Progression; Fibrosis; Kidney; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Ureteral Obstruction | 2019 |
Evaluation of intestinal permeation enhancement with carboxymethyl chitosan-rhein polymeric micelles for oral delivery of paclitaxel.
Topics: Administration, Oral; Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Chitosan; Disease Models, Animal; Drug Carriers; Drug Compounding; Humans; Intestinal Mucosa; Male; Mice; Micelles; Neoplasms; Paclitaxel; Permeability; Rats; Tissue Distribution; Verapamil | 2020 |
Renal protection of rhein against 5/6 nephrectomied-induced chronic kidney disease: role of SIRT3-FOXO3α signalling pathway.
Topics: Animals; Anthraquinones; Blood Urea Nitrogen; Cells, Cultured; Creatinine; Disease Models, Animal; Forkhead Box Protein O3; Kidney; Male; Nephrectomy; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renal Insufficiency, Chronic; Signal Transduction; Sirtuin 3 | 2020 |
Quantitative and network pharmacology: A case study of rhein alleviating pathological progress of renal interstitial fibrosis.
Topics: Animals; Anthraquinones; Cell Line; Computer Simulation; Disease Models, Animal; Fibrosis; Focal Adhesion Kinase 1; Humans; Kidney; Kidney Diseases; Models, Biological; Rats; Signal Transduction; Smad3 Protein; Systems Biology | 2020 |
Design and Evaluation of Rhein-Based MRI Contrast Agents for Visualization of Tumor Necrosis Induced by Combretastatin A-4 Disodium Phosphate.
Topics: Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Contrast Media; Disease Models, Animal; Drug Design; Humans; Liver Neoplasms, Experimental; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Necrosis; Rats; Rats, Sprague-Dawley; Stilbenes; Tissue Distribution | 2021 |
The Effects of Rhein and Honokiol on Metabolic Profiles in a Mouse Model of Acute Pancreatitis.
Topics: Amylases; Animals; Anthraquinones; Biphenyl Compounds; Disease Models, Animal; Enzyme Inhibitors; Lignans; Male; Metabolome; Mice; Mice, Inbred C57BL; Pancreas; Pancreatitis | 2020 |
Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment.
Topics: Animals; Anthraquinones; Biological Transport; Cell Line; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Models, Animal; Drug Carriers; Drug Liberation; Enzyme Inhibitors; Epithelial Cells; Humans; Hyaluronan Receptors; Hyaluronic Acid; Lactoferrin; Macrophages; Mice; Nanoparticles; NF-kappa B; Pectins; Receptors, Cell Surface; Tight Junction Proteins; Tissue Distribution; Toll-Like Receptor 4 | 2021 |
Rhein attenuates PTZ‑induced epilepsy and exerts neuroprotective activity via inhibition of the TLR4-NFκB signaling pathway.
Topics: Animals; Anthraquinones; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Humans; Male; Mice; Neuroprotective Agents; NF-kappa B; Pentylenetetrazole; Severity of Illness Index; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Rhein ameliorates adenomyosis by inhibiting NF-κB and β-Catenin signaling pathway.
Topics: Adenomyosis; Animals; Anthraquinones; Anti-Inflammatory Agents; beta Catenin; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Endometrium; Epithelial-Mesenchymal Transition; Female; Mice, Inbred ICR; NF-kappa B; Stromal Cells; Wnt Signaling Pathway | 2017 |
Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Anthraquinones; Cell Line; Cytokines; Disease Models, Animal; Glucuronidase; Glycosylation; Humans; Inflammation Mediators; Klotho Proteins; Lipopolysaccharides; Macrophages; Mice; Models, Biological; NF-kappa B; Proteolysis; Toll-Like Receptor 4 | 2018 |
A novel phenolic propanediamine moiety-based lung-targeting therapy for asthma.
Topics: A549 Cells; Animals; Anthraquinones; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Line, Tumor; Disease Models, Animal; HeLa Cells; Humans; Lung; Male; Mice; Rats; Rats, Wistar; Sulfhydryl Compounds | 2018 |
Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-
Topics: Animals; Anthraquinones; Blood Glucose; Cell Death; Chromatography, Gel; Diabetic Nephropathies; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Endocytosis; Fasting; Hemolysis; Humans; Kidney; Kinetics; Male; Mice, Inbred C57BL; Nanoparticles; Particle Size; Polyethylene Glycols; Polyethyleneimine; Rabbits; Static Electricity; Streptozocin; Subcellular Fractions | 2018 |
Untangling the thread of life spun by αKlotho.
Topics: Acute Kidney Injury; Animals; Anthraquinones; Disease Models, Animal; Drugs, Chinese Herbal; Glucuronidase; Klotho Proteins; Mice; Receptors, Cell Surface | 2018 |
Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Inflammation; Interleukin-1beta; Intestinal Mucosa; Intestine, Small; Lipopolysaccharides; Male; Malondialdehyde; MAP Kinase Signaling System; NF-E2-Related Factor 2; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2019 |
Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia.
Topics: Aloe; Animals; Anthraquinones; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Emodin; Male; Plant Extracts; Rats; Rheum | 2019 |
Pharmacokinetic and pharmacodynamic studies of four major phytochemical components of Da-Cheng-Qi decoction to treat acute pancreatitis.
Topics: Animals; Anthraquinones; Apoptosis; Biphenyl Compounds; Cells, Cultured; Disease Models, Animal; Drugs, Chinese Herbal; Flavanones; Hesperidin; Lignans; Male; Necrosis; Pancreas; Pancreatitis, Acute Necrotizing; Phytotherapy; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2013 |
Rhein lysinate decreases the generation of β-amyloid in the brain tissues of Alzheimer's disease model mice by inhibiting inflammatory response and oxidative stress.
Topics: Aging; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anthraquinones; Brain; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glutathione Peroxidase; Interleukin-6; Lysine; Male; Malondialdehyde; Mice; Oxidative Stress; Sirtuin 1; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2013 |
Effects of rhein on intestinal epithelial tight junction in IgA nephropathy.
Topics: Animals; Anthraquinones; Disease Models, Animal; Epithelial Cells; Female; Glomerulonephritis, IGA; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Lactulose; Mannose; Occludin; Permeability; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tight Junctions; Time Factors; Zonula Occludens-1 Protein | 2013 |
[Protective effects of rhein on hepatic progression in HBV-transgenic mice with nonalcoholic steatohepatitis induced by a high-fat diet].
Topics: Animals; Anthraquinones; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Glucose; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Non-alcoholic Fatty Liver Disease | 2013 |
Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes.
Topics: Amino Acid Transport Systems, Basic; Animals; Anthraquinones; Area Under Curve; Biotransformation; Carboxylic Ester Hydrolases; Cholesterol 7-alpha-Hydroxylase; Chromatography, Liquid; Constipation; Cytochrome P450 Family 2; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Half-Life; Laxatives; Loperamide; Male; Metabolic Clearance Rate; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Phytotherapy; Plants, Medicinal; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Sodium-Potassium-Exchanging ATPase; Spectrometry, Mass, Electrospray Ionization; Steroid 21-Hydroxylase; Tandem Mass Spectrometry | 2014 |
Anti-hyperuricemic and nephroprotective effects of rhein in hyperuricemic mice.
Topics: Animals; Anthraquinones; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drugs, Chinese Herbal; Hyperuricemia; Interleukin-1beta; Kidney; Kidney Diseases; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Phytotherapy; Protective Agents; Rheum; Tumor Necrosis Factor-alpha; Uric Acid | 2015 |
Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-κB activities.
Topics: Acute Kidney Injury; Animals; Anthraquinones; Blood Urea Nitrogen; Cell Line; Creatine; Disease Models, Animal; I-kappa B Kinase; I-kappa B Proteins; Immunohistochemistry; Interleukin-1beta; Interleukin-8; Kidney; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Sepsis; Signal Transduction; Transcription Factor RelA; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2015 |
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Topics: Adenine; Animals; Anthraquinones; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Down-Regulation; Enzyme Inhibitors; Femur; Gene Expression Regulation; Glucuronidase; Kidney; Klotho Proteins; Male; Mice; Mice, Inbred C57BL; Osteoporosis; Promoter Regions, Genetic; Renal Insufficiency, Chronic; Rheum; RNA Interference; Up-Regulation | 2017 |
A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.
Topics: Administration, Oral; Animals; Anthraquinones; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Emodin; Female; Kidney; Liver; Male; Plant Roots; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Rheum; Spleen; Tandem Mass Spectrometry; Tissue Distribution | 2011 |
[Effect of early intervention with rhein on islet function in db/db mice].
Topics: Animals; Anthraquinones; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice | 2011 |
Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats.
Topics: Administration, Cutaneous; Amylases; Animals; Anthraquinones; Arginine; Disease Models, Animal; Drugs, Chinese Herbal; Emodin; Male; Ointments; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley | 2013 |
Effects of diacerein on indomethacin-induced gastric ulceration.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dinoprostone; Disease Models, Animal; Ethanol; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Male; Neutrophils; Rats; Reactive Oxygen Species; Stomach Ulcer | 2001 |