rhein has been researched along with Arthritis, Degenerative in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdallah, OY; Ebada, HM; Nasra, MM; Nassra, RA; Solaiman, AA | 1 |
| Abdallah, OY; Ebada, HMK; Nasra, MMA; Nassra, RA | 1 |
| Jain, M; Joharapurkar, A; Patel, V | 1 |
| Avendaño-Godoy, J; Gómez-Gaete, C; Poblete, MG; Ramos, RG | 1 |
| Abdallah, OY; Ebada, HMK; Elnaggar, YSR; Nasra, MMA; Nassra, RA; Solaiman, AA | 1 |
| Bustos, P; Castillo, D; Chávez, C; Ferreira, F; Godoy, R; Gómez-Gaete, C; Mennickent, S; Novoa, P | 1 |
| Abhay, H; Dhaneshwar, S; Dipmala, P; Prashant, B | 1 |
| Bustos, P; Chávez, C; Godoy, R; Gómez-Gaete, C; Retamal, M; Torres-Vergara, P | 1 |
| Bianchi, A; Deffaud, J; Domagala, F; Ficheux, H; Jouzeau, JY; Kirchmeyer, M; Netter, P | 1 |
| Bogdanowicz, P; Domagala, F; Ficheux, H; Martin, G; Pujol, JP | 1 |
| Aloisi, R; Fioravanti, A; Leo, G; Mian, M; Savarino, L | 1 |
| Brun, PH | 1 |
| Shirazi, I; Yaron, I; Yaron, M | 2 |
| Cloutier, JM; Jolicoeur, FC; Martel-Pelletier, J; Mineau, F; Pelletier, JP | 1 |
| Duval, N; Fernandes, JC; Martel-Pelletier, J; Mineau, F; Pelletier, JP | 1 |
| Cloutier, JM; Jolicoeur, FC; Martel-Pelletier, J; Moldovan, F; Pelletier, JP | 1 |
| Borderie, D; Ekindjian, O; Hernvann, A; Lemarechal, H; Menkes, CJ | 1 |
| Ishiwa, J; Ito, A; Kosaka, N; Nagase, H; Sato, T; Tamura, T | 1 |
| Fernandes, JC; Lajeunesse, D; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Reboul, P; Sabouret, P | 1 |
1 review(s) available for rhein and Arthritis, Degenerative
| Article | Year |
|---|---|
Therapeutic Potential of Diacerein in Management of Pain.
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Glutamates; Histamine; Humans; Matrix Metalloproteinases; Nitric Oxide; Osteoarthritis; Pain; Prostaglandins; Substance P; Transient Receptor Potential Channels | 2022 |
19 other study(ies) available for rhein and Arthritis, Degenerative
| Article | Year |
|---|---|
Cationic nanocarrier of rhein based on hydrophobic ion pairing approach as intra-articular targeted regenerative therapy for osteoarthritis.
Topics: Animals; Anthraquinones; Cartilage, Articular; Liposomes; Nanoparticles; Osteoarthritis; Rats | 2022 |
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment.
Topics: Animals; Anthraquinones; Cartilage, Articular; Chemistry, Pharmaceutical; Chondroitin Sulfates; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Lipids; Male; Nanoparticles; Osteoarthritis; Oxidative Stress; Particle Size; Random Allocation; Rats; Rats, Wistar; Surface Properties | 2022 |
Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis.
Topics: Gamma Rays; Humans; Lactic Acid; Microspheres; Osteoarthritis; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sterilization | 2023 |
Novel rhein integrate transphytosomes as non-invasive local therapy for osteoarthritis to ameliorate cartilage deterioration in MIA-arthritic rats.
Topics: Administration, Cutaneous; Animals; Anthraquinones; Cartilage, Articular; Osteoarthritis; Rats | 2021 |
Optimization of rhein-loaded polymeric nanoparticles using a factorial design and evaluation of the cytotoxic and anti-inflammatory effects.
Topics: Anthraquinones; Cell Line, Tumor; Cell Survival; Culture Media; Cytokines; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Drug Liberation; Drug Screening Assays, Antitumor; Emulsions; Enzyme Inhibitors; Humans; Macrophages; Nanoparticles; Osteoarthritis; Polymers; Reactive Oxygen Species | 2018 |
Disease-modifying effect of anthraquinone prodrug with boswellic acid on collagenase-induced osteoarthritis in Wistar rats.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Anti-Ulcer Agents; Body Weight; Collagenases; Edema; Male; Osteoarthritis; Prodrugs; Rats; Rats, Wistar; Triterpenes | 2013 |
Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis.
Topics: Absorbable Implants; Anthraquinones; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Drug Evaluation, Preclinical; Humans; Microspheres; Osteoarthritis; Treatment Outcome | 2017 |
Modulatory effect of rhein on IL-1alpha-induced responses in human chondrocytes: a comparative study between antibody microarrays and specific ELISAs.
Topics: Anthraquinones; Antibodies; Cartilage, Articular; Chemokines; Chondrocytes; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Interleukin-1; Nitrites; Osteoarthritis; Protein Array Analysis | 2008 |
Rhein inhibits interleukin-1 beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia: a potential mechanism for its disease-modifying effect in osteoarthritis.
Topics: Animals; Anthraquinones; Cattle; Cell Hypoxia; Cells, Cultured; Chondrocytes; DNA; Enzyme Inhibitors; Interleukin-1; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; NF-kappa B; Osteoarthritis; Protein Binding; Transcription Factor AP-1 | 2003 |
Anthraquinone-2,6-disulfonic acid as a disease-modifying osteoarthritis drug: an in vitro and in vivo study.
Topics: Animals; Anthraquinones; Cartilage, Articular; Cathepsin B; Disease Progression; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Osteoarthritis; Rabbits | 2007 |
Effect of diacetylrhein on the development of experimental osteoarthritis. A biochemical investigation.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Humans; Osteoarthritis | 1997 |
[Anti-interleukin-1 effects of diacerhein in vitro].
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Culture Techniques; Humans; Interleukin-1; Lipopolysaccharides; NADH, NADPH Oxidoreductases; Osteoarthritis; Proteoglycans; Synovial Membrane | 1997 |
In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes.
Topics: Aged; Anthraquinones; Blotting, Northern; Cells, Cultured; Chondrocytes; Culture Techniques; Enzyme Inhibitors; Female; Humans; Interleukin-1; Lipopolysaccharides; Male; Matrix Metalloproteinase 3; Middle Aged; Osteoarthritis; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Synovial Membrane; Tumor Necrosis Factor-alpha | 1998 |
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.
Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Male; Membrane Proteins; Middle Aged; Naproxen; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis; Prostaglandin-Endoperoxide Synthases | 1998 |
Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures.
Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Female; Humans; Interleukin-1; Male; Nitric Oxide; Osteoarthritis; Receptors, Interleukin-1 | 1999 |
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.
Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Cartilage, Articular; Caspase 1; Chondrocytes; Down-Regulation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Situ Hybridization; Interleukin-1; Interleukin-18; Male; Osteoarthritis; RNA, Messenger | 2000 |
Inhibition of the nitrosothiol production of cultured osteoarthritic chondrocytes by rhein, cortisol and diclofenac.
Topics: Aged; Anthraquinones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chondrocytes; Diclofenac; Enzyme Inhibitors; Female; Humans; Hydrocortisone; In Vitro Techniques; Male; Mercaptoethanol; Nitric Oxide; Nitroso Compounds; Osteoarthritis; S-Nitrosothiols | 2001 |
Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Chondrocytes; Down-Regulation; Enzyme Inhibitors; Hindlimb; Joints; Matrix Metalloproteinases; Osteoarthritis; Protease Inhibitors; Rabbits; Tissue Inhibitor of Metalloproteinases | 2001 |
Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.
Topics: Aged; Aged, 80 and over; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Bone Remodeling; Cells, Cultured; Female; Humans; Male; Middle Aged; Osteoarthritis; Osteoblasts | 2001 |