retinol-palmitate has been researched along with Xerophthalmia* in 3 studies
1 trial(s) available for retinol-palmitate and Xerophthalmia
| Article | Year |
|---|---|
Early serum changes in severely malnourished children with corneal xerophthalmia after injection of water-miscible vitamin A.
We have studied the response of malnourished, xerophthalmic children to injections of water-miscible vitamin A to assess the most effective dose. Total dose injected was either greater than 100,000, 100,000, or 50,000 IU. Serum levels of retinol-binding protein, prealbumin, retinyl esters, and retinol were estimated. More than half the children given the largest does had exceptionally high serum retinyl esters and a high molar ratio of retinol and retinyl esters to retinol-binding protein. In no group did retinol-binding protein or prealbumin reach normal levels 24 h after dose. Eye recovery and weight gain was so good after 50,000 IU as after higher doses. The possible toxicity of retinyl esters and free retinol in serum is discussed and the level of vitamin A in normal liver is considered in relation to therapeutic doses. The role of protein deficiency in influencing response to dose is reviewed. Topics: Child; Corneal Diseases; Diterpenes; Dose-Response Relationship, Drug; Female; Humans; Male; Nutrition Disorders; Palmitates; Retinol-Binding Proteins; Retinyl Esters; Vitamin A; Xerophthalmia | 1981 |
2 other study(ies) available for retinol-palmitate and Xerophthalmia
| Article | Year |
|---|---|
Advanced keratomalacia with descemetocele in an infant with cystic fibrosis.
Topics: Corneal Diseases; Cystic Fibrosis; Descemet Membrane; Diterpenes; Female; Hernia; Humans; Infant; Keratoplasty, Penetrating; Retinyl Esters; Vitamin A; Xerophthalmia | 2005 |
Xerophthalmia and cystic fibrosis.
We treated two infants with failure to thrive who presented with clinical evidence of conjunctival and corneal xerosis. One patient was referred with possible infectious corneal ulcer thought to exist because there were deep peripheral ulcerations of the cornea and associated hypopyon. The other patient was initially thought to have a nasolacrimal duct obstruction because of excessive tearing. Xerophthalmia secondary to vitamin A deficiency was suspected and led to the diagnosis and treatment of cystic fibrosis in each case. Therapy with vitamin A promptly resolved the xerosis, but it also caused a transient rise in intracerebral pressure. Xerophthalmia can still be a problem in developed countries when underlying disorders, such as cystic fibrosis, lead to vitamin A malabsorption. Topics: Cystic Fibrosis; Diterpenes; Female; Humans; Infant; Malabsorption Syndromes; Male; Retinyl Esters; Vitamin A; Vitamin A Deficiency; Xerophthalmia | 1990 |