retinol-palmitate and Uterine-Cervical-Dysplasia

retinol-palmitate has been researched along with Uterine-Cervical-Dysplasia* in 2 studies

Other Studies

2 other study(ies) available for retinol-palmitate and Uterine-Cervical-Dysplasia

Article	Year
[Changes in the vitamin A status in dysplastic epithelium of the cervix]. Zentralblatt fur Gynakologie, 1995, Volume: 117, Issue:9 In 34 patients with HVP-infection of the cervix and in 40 patients with CIN III standardised biopsies were taken from the involved area and normal cervical epithelium for determination of the local concentration of retinylester. In all cases diagnosis was confirmed colposcopically, cytologically and by histology. HPV infection was confirmed by in situ hybridisation. Determination of retinylester was performed by HPLC. No significant difference of local retinyl-plamitate concentration was detectable in HPV infected versus normal tissue. Retinyl-palmitate concentration was extremely lower in CIN III compared with normal cervical epithelium and HPV-infected tissue. The determination of plasma level of retinol showed no significant difference between the two groups. So it can be presumed that the reduction of retinyl-palmitat in CIN III is a local process and a local supplementation of Vitamin A might contribute to the prevention of cervical neoplasia. Topics: Anticarcinogenic Agents; Biopsy; Cell Transformation, Neoplastic; Cervix Uteri; Colposcopy; Diterpenes; Female; Humans; Neoplasm Staging; Papillomaviridae; Papillomavirus Infections; Retinyl Esters; Tumor Virus Infections; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Vitamin A	1995
Studies of retinoids in the prevention and treatment of cancer. Journal of the American Academy of Dermatology, 1982, Volume: 6, Issue:4 Pt 2 Sup Investigation of retinoids for anticancer activity in humans, either in the chemopreventive or treatment mode, has been little studied. We summarize here our ongoing investigations in four different areas: (1) secondary prevention of cervical dysplasia with topical application of all-trans-retinoic acid; (2) adjuvant treatment of resected high-risk stage I and II malignant melanoma with bacille Calmette Guérin (BCG) plus or minus oral vitamin A; (3) topical vitamin A acid therapy for cutaneous metastatic melanoma; an (4) oral isotretinoin as an anticancer agent. Topics: Diterpenes; Female; Humans; Isomerism; Isotretinoin; Melanoma; Neoplasms; Palmitates; Retinyl Esters; Skin Neoplasms; Tretinoin; Uterine Cervical Dysplasia; Vitamin A	1982

Article

Year

[Changes in the vitamin A status in dysplastic epithelium of the cervix].

Zentralblatt fur Gynakologie, 1995, Volume: 117, Issue:9

In 34 patients with HVP-infection of the cervix and in 40 patients with CIN III standardised biopsies were taken from the involved area and normal cervical epithelium for determination of the local concentration of retinylester. In all cases diagnosis was confirmed colposcopically, cytologically and by histology. HPV infection was confirmed by in situ hybridisation. Determination of retinylester was performed by HPLC. No significant difference of local retinyl-plamitate concentration was detectable in HPV infected versus normal tissue. Retinyl-palmitate concentration was extremely lower in CIN III compared with normal cervical epithelium and HPV-infected tissue. The determination of plasma level of retinol showed no significant difference between the two groups. So it can be presumed that the reduction of retinyl-palmitat in CIN III is a local process and a local supplementation of Vitamin A might contribute to the prevention of cervical neoplasia.

Topics: Anticarcinogenic Agents; Biopsy; Cell Transformation, Neoplastic; Cervix Uteri; Colposcopy; Diterpenes; Female; Humans; Neoplasm Staging; Papillomaviridae; Papillomavirus Infections; Retinyl Esters; Tumor Virus Infections; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Vitamin A

1995

Studies of retinoids in the prevention and treatment of cancer.

Journal of the American Academy of Dermatology, 1982, Volume: 6, Issue:4 Pt 2 Sup

Investigation of retinoids for anticancer activity in humans, either in the chemopreventive or treatment mode, has been little studied. We summarize here our ongoing investigations in four different areas: (1) secondary prevention of cervical dysplasia with topical application of all-trans-retinoic acid; (2) adjuvant treatment of resected high-risk stage I and II malignant melanoma with bacille Calmette Guérin (BCG) plus or minus oral vitamin A; (3) topical vitamin A acid therapy for cutaneous metastatic melanoma; an (4) oral isotretinoin as an anticancer agent.

Topics: Diterpenes; Female; Humans; Isomerism; Isotretinoin; Melanoma; Neoplasms; Palmitates; Retinyl Esters; Skin Neoplasms; Tretinoin; Uterine Cervical Dysplasia; Vitamin A

1982