retinol-palmitate and Skin-Diseases

Topics: Aged; Anthracenes; Antioxidants; Benzoates; Bronchi; Diterpenes; Epithelial Cells; Female; Humans; In Vitro Techniques; Male; Middle Aged; Naphthols; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; Retinyl Esters; Skin Diseases; Smoking; Tetrahydronaphthalenes; Thiophenes; Tretinoin; Uteroglobin; Vitamin A

The usual presenting features of vitamin A intoxication are pseuotumor cerebri, skeletal pain, desquamative dermatitis, and hepatic inflammation. Our patient was a nine-year-old female who had increasing cough, dyspnea, and abdominal distention for a short time prior to admission. She was said to have been treated with 10,000 units of vitamin A per day for skin rashes. Radiographic studies revealed a very large right sided pleural effusion, ascites, demineralized bones, and retarded skeletal maturation. The diagnosis of hypervitaminosis A was made. More detailed medical history confirmed that the child had, in actuality, received up to 300,000 units/day of vitamin A plus desiccated liver pills and carrot juice for the previous year. Clinical symptoms completely abated following acute medical treatment for ascites and cessation of vitamin A intake. Several months later, a sample of liver, obtained and preserved at the time of exploratory laparotomy, was homogenized and extracted with ethanol/hexane. The retinyl palmitate level was significantly elevated and consistent with vitamin A poisoning.

Topics: Age Determination by Skeleton; Ascites; Biopsy; Child; Diterpenes; Female; Humans; Hypervitaminosis A; Liver; Microscopy, Electron; Pleural Effusion; Radiography, Thoracic; Retinyl Esters; Skin Diseases; Vitamin A