retinol-palmitate and Hoarseness

retinol-palmitate has been researched along with Hoarseness* in 1 studies

Trials

1 trial(s) available for retinol-palmitate and Hoarseness

Article	Year
Inhalation of aerosolized vitamin a: reversibility of metaplasia and dysplasia of human respiratory epithelia -- a prospective pilot study. European journal of medical research, 2002, Feb-21, Volume: 7, Issue:2 The objective of this preliminary uncontrolled study was twofold: First, to assess the feasibility of retinyl palmitate inhalation and second, to analyze the changes of metaplastic lesions of the respiratory epithelium (metaplasia or dysplasia) following retinyl palmitate inhalation. The response to a daily dose of 18.000 I.U. retinyl palmitate by inhalation over a period of 3 month was assessed in 11 subjects (9 smokers, 2 ex-smokers). Using white-light bronchoscopy combined with autofluorescence bronchoscopy, bronchial biopsies were taken before and after a 3 month-period. The biopsy samples were evaluated blind by a referee lung pathologist. The overall response rate (remission or partial remission) was 56% (95% CI 0.30 0.79; p<0.05). These data suggest that inhalation of retinyl esters could be a promising therapeutical approach for chemoprevention of lung cancer. Vitamin A; chemoprevention; lung cancer; squamous metaplasia; dysplasia; retinoids Topics: Administration, Inhalation; Aerosols; Biopsy; Bronchi; Bronchoscopy; Diterpenes; Female; Fluorescence; Hoarseness; Humans; Male; Metaplasia; Middle Aged; Pilot Projects; Precancerous Conditions; Prospective Studies; Remission Induction; Respiratory Mucosa; Retinyl Esters; Smoking; Treatment Outcome; Vitamin A	2002

Article

Year

Inhalation of aerosolized vitamin a: reversibility of metaplasia and dysplasia of human respiratory epithelia -- a prospective pilot study.

European journal of medical research, 2002, Feb-21, Volume: 7, Issue:2

The objective of this preliminary uncontrolled study was twofold: First, to assess the feasibility of retinyl palmitate inhalation and second, to analyze the changes of metaplastic lesions of the respiratory epithelium (metaplasia or dysplasia) following retinyl palmitate inhalation. The response to a daily dose of 18.000 I.U. retinyl palmitate by inhalation over a period of 3 month was assessed in 11 subjects (9 smokers, 2 ex-smokers). Using white-light bronchoscopy combined with autofluorescence bronchoscopy, bronchial biopsies were taken before and after a 3 month-period. The biopsy samples were evaluated blind by a referee lung pathologist. The overall response rate (remission or partial remission) was 56% (95% CI 0.30 0.79; p<0.05). These data suggest that inhalation of retinyl esters could be a promising therapeutical approach for chemoprevention of lung cancer. Vitamin A; chemoprevention; lung cancer; squamous metaplasia; dysplasia; retinoids

Topics: Administration, Inhalation; Aerosols; Biopsy; Bronchi; Bronchoscopy; Diterpenes; Female; Fluorescence; Hoarseness; Humans; Male; Metaplasia; Middle Aged; Pilot Projects; Precancerous Conditions; Prospective Studies; Remission Induction; Respiratory Mucosa; Retinyl Esters; Smoking; Treatment Outcome; Vitamin A

2002