retinol-palmitate and Cell-Transformation--Viral

retinol-palmitate has been researched along with Cell-Transformation--Viral* in 2 studies

Other Studies

2 other study(ies) available for retinol-palmitate and Cell-Transformation--Viral

Article	Year
Effects of retinoids on invasion of organ cultures of chick chorioallantoic membrane by adenovirus transformed cells. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1985, Volume: 21, Issue:7 Invasion of chick chorioallantoic membrane (CAM) organ cultures by rat 3Y1 cells transformed by the highly oncogenic human adenovirus type 12 (3Y1/12-10 cells) was inhibited by several retinoids tested. The anti-invasive activity of the retinoids was dependent on retinoid concentration and continuous (4 d) exposure of the CAM. The 50% retinoid dose (dose effective in achieving a response in half of the organ cultures) that inhibited invasion was 0.85 micrograms/ml of retinol palmitate, 0.39 micrograms/ml of retinoic acid, or 0.16 micrograms/ml of retinol acetate. This dose was of the same order of magnitude as that which induced CAM differentiation, and was three- to fourfold less than the dose that caused cytotoxic damage of CAM. In addition, the retinoids inhibited 3Y1/12-10 cell growth by approximately 40% at levels over 10-fold higher than those needed for anti-invasion activity. The findings suggest that the anti-invasive activity of retinoids was at least partly due to direct induction of cell differentiation of the CAM host tissue. Topics: Adenoviruses, Human; Allantois; Animals; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Chorion; Diterpenes; Extraembryonic Membranes; Neoplasm Invasiveness; Organ Culture Techniques; Rats; Retinoids; Retinyl Esters; Tretinoin; Vitamin A	1985
Stimulation of cell proliferation by vitamin A derivatives on murine sarcoma virus-transformed mouse cells in serum-free culture. Experimental cell research, 1983, Apr-15, Volume: 145, Issue:1 The effect of retinoids (Rds) on cell proliferation was studied in serum-free culture condition, using non-transformed and transformed derivatives of BALB 3T3. Cell proliferation of an SV40-transformed line was inhibited significantly by Rd treatment. However, proliferation of two cell lines that were transformed by a Kirsten and Moloney strain of murine sarcoma virus (MSV) and produced growth factor into culture medium, was remarkably stimulated by Rds. Addition of serum masked both the inhibitory and stimulatory effects of Rds. Topics: Animals; Blood; Cell Line; Cell Transformation, Viral; Culture Media; Diterpenes; Dose-Response Relationship, Drug; Growth Substances; Kirsten murine sarcoma virus; Mice; Retinaldehyde; Retinyl Esters; Sarcoma Viruses, Murine; Simian virus 40; Tretinoin; Vitamin A	1983

Article

Year

Effects of retinoids on invasion of organ cultures of chick chorioallantoic membrane by adenovirus transformed cells.

In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1985, Volume: 21, Issue:7

Invasion of chick chorioallantoic membrane (CAM) organ cultures by rat 3Y1 cells transformed by the highly oncogenic human adenovirus type 12 (3Y1/12-10 cells) was inhibited by several retinoids tested. The anti-invasive activity of the retinoids was dependent on retinoid concentration and continuous (4 d) exposure of the CAM. The 50% retinoid dose (dose effective in achieving a response in half of the organ cultures) that inhibited invasion was 0.85 micrograms/ml of retinol palmitate, 0.39 micrograms/ml of retinoic acid, or 0.16 micrograms/ml of retinol acetate. This dose was of the same order of magnitude as that which induced CAM differentiation, and was three- to fourfold less than the dose that caused cytotoxic damage of CAM. In addition, the retinoids inhibited 3Y1/12-10 cell growth by approximately 40% at levels over 10-fold higher than those needed for anti-invasion activity. The findings suggest that the anti-invasive activity of retinoids was at least partly due to direct induction of cell differentiation of the CAM host tissue.

Topics: Adenoviruses, Human; Allantois; Animals; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Chorion; Diterpenes; Extraembryonic Membranes; Neoplasm Invasiveness; Organ Culture Techniques; Rats; Retinoids; Retinyl Esters; Tretinoin; Vitamin A

1985

Stimulation of cell proliferation by vitamin A derivatives on murine sarcoma virus-transformed mouse cells in serum-free culture.

Experimental cell research, 1983, Apr-15, Volume: 145, Issue:1

The effect of retinoids (Rds) on cell proliferation was studied in serum-free culture condition, using non-transformed and transformed derivatives of BALB 3T3. Cell proliferation of an SV40-transformed line was inhibited significantly by Rd treatment. However, proliferation of two cell lines that were transformed by a Kirsten and Moloney strain of murine sarcoma virus (MSV) and produced growth factor into culture medium, was remarkably stimulated by Rds. Addition of serum masked both the inhibitory and stimulatory effects of Rds.

Topics: Animals; Blood; Cell Line; Cell Transformation, Viral; Culture Media; Diterpenes; Dose-Response Relationship, Drug; Growth Substances; Kirsten murine sarcoma virus; Mice; Retinaldehyde; Retinyl Esters; Sarcoma Viruses, Murine; Simian virus 40; Tretinoin; Vitamin A

1983