retinaldehyde and Lentigo

To assess an objective method evaluating the effects of a retinaldehyde-based cream (RA-cream) on solar lentigines; 29 women randomly applied RA-cream on lentigines of one hand and a control cream on the other, once daily for 3 months.. A specific method enabling a reliable visualisation of the lesions was proposed, using high-magnification colour-calibrated camera imaging. Assessment was performed using clinical evaluation by Physician Global Assessment score and image analysis. Luminance determination on the numeric images was performed either on the basis of 5 independent expert's consensus borders or probability map analysis via an algorithm automatically detecting the pigmented area.. Both image analysis methods showed a similar lightening of ΔL* = 2 after a 3-month treatment by RA-cream, in agreement with single-blind clinical evaluation.. High-magnification colour-calibrated camera imaging combined with probability map analysis is a fast and precise method to follow lentigo depigmentation.

Topics: Aged; Aged, 80 and over; Color; Colorimetry; Dermoscopy; Female; Humans; Lentigo; Middle Aged; Photography; Reproducibility of Results; Retinaldehyde; Sensitivity and Specificity; Skin Cream; Skin Lightening Preparations; Solar Energy; Treatment Outcome

Solar lentigines are common benign macular hyperpigmented lesions localized on sun-exposed areas.. To evaluate the efficacy and safety of a new depigmenting agent containing a retinoid (retinaldehyde), a new phenolic agent (4-(1-phenylethyl)-resorcinol) and a reducing agent (δ-tocopheryl-β-D-glucopyranoside) in the topical treatment of solar lentigines.. Twenty patients with solar lentigines of the face and hands applied the depigmenting agent on each lentigo once daily for 12 weeks. The outcome was evaluated at 45 days (T1) and 3 months (T2) after the end of treatment compared to baseline (T0) by means of clinical evaluation, Mexameter® and Visioface devices for digital and ultraviolet computerized image analysis of skin color as well as in vivo reflectance confocal microscopy.. Image analysis and confocal laser reflectance microscopy showed that hyperpigmentation was significantly reduced at T2 compared to baseline and to controls.. The study treatment was well tolerated and showed significant improvement in the depigmentation of solar lentigines.

Topics: Adult; Drug Combinations; Facial Dermatoses; Female; Glucosides; Hand Dermatoses; Humans; Hyperpigmentation; Image Processing, Computer-Assisted; Lentigo; Microscopy, Confocal; Middle Aged; Reducing Agents; Resorcinols; Retinaldehyde; Skin Lightening Preparations; Tocopherols