retinaldehyde and Intervertebral-Disc-Displacement

retinaldehyde has been researched along with Intervertebral-Disc-Displacement* in 1 studies

Other Studies

1 other study(ies) available for retinaldehyde and Intervertebral-Disc-Displacement

Article	Year
Inhibition of phospholipase A2 purified from human herniated disc. Biochemical pharmacology, 1993, Feb-09, Volume: 45, Issue:3 The effect on human herniated intervertebral disc phospholipase A2 (HD-PLA2) of a number of retinoids, antirheumatic drugs and reported PLA2 inhibitors was evaluated using autoclaved [1-14C]-oleate-labeled Escherichia coli membranes as the substrate. Dexamethasone, non-steroidal antiinflammatory drugs, aristolochic acid and retinol were inactive, whereas a marked inhibition was found for manoalide, retinal, nordihydroguaiaretic acid and p-bromophenacyl bromide after preincubation with the enzyme (IC50 values 0.25, 4, 5 and 5 microM, respectively). The results are parallel to those obtained with the PLA2 purified from human synovial fluid. Topics: Acetophenones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Laminectomy; Masoprocol; Phospholipases A; Phospholipases A2; Retinaldehyde; Synovial Fluid; Terpenes	1993

Article

Year

Inhibition of phospholipase A2 purified from human herniated disc.

Biochemical pharmacology, 1993, Feb-09, Volume: 45, Issue:3

The effect on human herniated intervertebral disc phospholipase A2 (HD-PLA2) of a number of retinoids, antirheumatic drugs and reported PLA2 inhibitors was evaluated using autoclaved [1-14C]-oleate-labeled Escherichia coli membranes as the substrate. Dexamethasone, non-steroidal antiinflammatory drugs, aristolochic acid and retinol were inactive, whereas a marked inhibition was found for manoalide, retinal, nordihydroguaiaretic acid and p-bromophenacyl bromide after preincubation with the enzyme (IC50 values 0.25, 4, 5 and 5 microM, respectively). The results are parallel to those obtained with the PLA2 purified from human synovial fluid.

Topics: Acetophenones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Intervertebral Disc; Intervertebral Disc Displacement; Laminectomy; Masoprocol; Phospholipases A; Phospholipases A2; Retinaldehyde; Synovial Fluid; Terpenes

1993