reticuline and Celiac-Disease

We evaluated the presence of IgA and IgG celiac disease-related antibodies in a sample of 217 patients with multiple sclerosis (MS) and in a sample of 200 controls not affected by neurological disorders. None of the 217 patients with MS presented IgG and IgA anti-gliadin, anti-endomysial antibodies, anti-tissue transglutaminase and anti-reticulin, whereas only one of the selected controls presented specific antibodies; this subject resulted to be effectively affected by celiac disease. Our data did not show an increased frequency of celiac disease among patients with MS.

Topics: Adult; Autoantibodies; Benzylisoquinolines; Celiac Disease; Female; Gliadin; Humans; Immunoglobulin A; Immunoglobulin G; Male; Middle Aged; Multiple Sclerosis; Seroepidemiologic Studies; Transglutaminases

We report the results of indirect immunofluorescent (IFI) detection of IgA and IgG antireticulin antibodies (IgA-ARA and IgG-ARA, respectively) in 283 serum samples from pediatric patients with coeliac disease (with and without gluten containing diets), patients with non-coeliac gastrointestinal disease, patients without gastrointestinal disease (control group) and patients with an increased risk for coeliac disease (diabetes mellitus, dermatitis herpetiformis or first grade relatives of coeliac patients). Our results indicate that IgA-ARA is a reproducible marker, with high positive (99-100%) and negative (100%) prediction values, when it is applied to children who have been on gluten containing diets for a long time (more than six months). The IgA-ARA measurement is not applicable in cases of selective IgA deficiency. Although IgG-ARA has a high predictive positive value, its low predictive negative value makes it a poor diagnostic tool. In the risk groups, our results suggest that these antibodies are useful in patient selection for intestinal biopsy.

Topics: Adolescent; Alkaloids; Benzylisoquinolines; Biomarkers; Celiac Disease; Child; Child, Preschool; Female; Fluorescent Antibody Technique; Humans; Immunoglobulin A; Immunoglobulin G; Infant; Isoquinolines; Male

Topics: Alkaloids; Autoantibodies; Benzylisoquinolines; Celiac Disease; Dermatitis Herpetiformis; Fluorescent Antibody Technique; Humans; Isoquinolines