resorcinol has been researched along with Down Syndrome in 1 studies
resorcinol: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7951
resorcinol : A benzenediol that is benzene dihydroxylated at positions 1 and 3.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The types of structural chromosome aberrations observed in these investigations as well as the concentration of the test substance, which had to be added to induce a clastogenic effect, demonstrated that resorcin has to be regarded as a weak mutagenic substance." | 1.26 | [Investigations on the mutagenic and clastogenic activity of resorcin / Cytogenetic findings from different types of human cells (author's transl)]. ( Schulz, R; Schwanitz, G; Winterhoff, H, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schulz, R | 1 |
| Schwanitz, G | 1 |
| Winterhoff, H | 1 |
1 other study available for resorcinol and Down Syndrome
| Article | Year |
|---|---|
[Investigations on the mutagenic and clastogenic activity of resorcin / Cytogenetic findings from different types of human cells (author's transl)].
Topics: Amniotic Fluid; Cells, Cultured; Chromosome Aberrations; Down Syndrome; Humans; Karyotyping; Lymphoc | 1982 |