resorcinarene and Leukemia--Myelogenous--Chronic--BCR-ABL-Positive

A possible way of improving the activity and selectivity profile of antitumor agents is to design drug carrier systems employing soluble macromolecules. Thus, four resorcinarene-PAMAM-dendrimer conjugates of chlorambucil with different groups in the lower part of the macrocycle and different length dendritic arms showed a good stability of the chemical link between drug and spacer. Evaluation of the cytotoxicity of the resorcinarene-PAMAM-dendrimer-chlorambucil conjugate employing a sulforhodamine B (SRB) assay in K-562 (human chronic myelogenous leukemia cells) demonstrated that the conjugate was more potent as an antiproliferative agent than chlorambucil.

Topics: Antineoplastic Agents; Calixarenes; Chlorambucil; Dendrimers; Drug Carriers; Drug Screening Assays, Antitumor; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phenylalanine