resolvin-d5 has been researched along with Sepsis* in 1 studies
1 other study(ies) available for resolvin-d5 and Sepsis
Article | Year |
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Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5.
The mechanisms that drive programmed resolution of inflammation remain elusive. Here, we report the temporal regulation of soluble (s) and transmembrane (m) fibrinogen-like protein 2 (Fgl2) during inflammation and show that both sFgl2 and mFgl2 correlate with the outcome. The expression and ectodomain shedding of Fgl2 are respectively promoted by miR-466l and metalloproteinases (ADAM10 and ADAM17) during inflammation resolution. Deficiency of Fgl2 enhances polymorphonuclear neutrophil (PMN) infiltration but impairs macrophage (MΦ) maturation and phagocytosis and inhibits the production of n-3 docosapentaenoic acid-derived resolvin 5 (RvDp5). In contrast, administration of sFgl2 blunts PMN infiltration as well as promotes PMN apoptosis and RvDp5 biosynthesis. By activating ALX/FPR2, RvDp5 enhances sFgl2 secretion via ADAM17 and synergistically accelerates resolution of inflammation. These results uncover a previously unknown endogenous programmed mechanism by which Fgl2 regulates resolution of inflammation and shed new light on clinical sepsis treatments. Topics: ADAM10 Protein; ADAM17 Protein; Adult; Animals; Docosahexaenoic Acids; Fibrinogen; Humans; Inflammation; Macrophages; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Middle Aged; Neutrophils; Sepsis; Young Adult | 2019 |