resolvin-d2 has been researched along with Liver-Cirrhosis* in 1 studies
1 other study(ies) available for resolvin-d2 and Liver-Cirrhosis
| Article | Year |
|---|---|
Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging.
Aging is associated with nonresolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a proresolving ligand that acts through the G-protein-coupled receptor called GPR18. Unbiased RNA sequencing revealed increased Gpr18 expression in macrophages from old mice, and in livers from elderly humans, which was associated with increased steatosis and fibrosis in middle-aged (MA) and old mice. MA mice that lacked GPR18 on myeloid cells had exacerbated steatosis and hepatic fibrosis, which was associated with a decline in Mac2 Topics: Aged; Aging; Animals; Bone Marrow; Collagen; Fatty Liver; Fibrosis; Humans; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Middle Aged; Receptors, G-Protein-Coupled | 2023 |