resolvin-d1 and Nephrocalcinosis

Intrarenal calcium oxalate (CaOx) crystals induce renal tubular epithelial cell (TEC) inflammatory and oxidative injury. This study is aimed at exploring potential therapeutic lipid components in kidney stones because lipids are involved in the development of several diseases and indicate the risk of kidney stones. Serum specimens were collected from 35 kidney stone patients and 35 normal controls. The lipid components in serum were measured, and differences were analyzed. The documented biological importance was comprehensively reviewed to identify lipids that differed significantly between the two groups to find potential agents associated with kidney stones. CaOx nephrocalcinosis mouse model was established to examine the therapeutic effects of specific lipids on CaOx deposition and CaOx-induced oxidative renal injury. Several lipids with significantly different levels were present in the serum of patients with stones and normal controls. Resolvin D1 (RvD1) (4.93-fold change,

Topics: Adult; Aged; Animals; Anti-Inflammatory Agents; Antioxidants; Calcium Oxalate; Case-Control Studies; Disease Models, Animal; Docosahexaenoic Acids; Female; Glyoxylates; Humans; Kidney Calculi; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nephrocalcinosis; Oxidative Stress; Reactive Oxygen Species; Signal Transduction