resminostat has been researched along with Hodgkin-Disease* in 1 studies
1 trial(s) available for resminostat and Hodgkin-Disease
Article | Year |
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Resminostat in patients with relapsed or refractory Hodgkin lymphoma: results of the phase II SAPHIRE study.
This open-label, single-arm phase II study examined efficacy, safety, pharmacokinetics, and biomarkers of histone deacetylase (HDAC) inhibitor resminostat in patients with relapsed or refractory Hodgkin lymphoma. Thirty-seven heavily pretreated patients received 600 (19 patients) or 800 mg (18 patients) oral resminostat daily for the initial 5 days of 14-day treatment cycles. Objective response rate (ORR) (primary) was 34% reaching disease control in 54% patients. Most patients (69%) showed reduced tumor size and reduced [ Topics: Adult; Aged; Antineoplastic Agents; Biomarkers; Drug Resistance, Neoplasm; Female; Histone Deacetylase Inhibitors; Hodgkin Disease; Humans; Hydroxamic Acids; Kaplan-Meier Estimate; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Recurrence; Retreatment; Sulfonamides; Treatment Outcome; Young Adult | 2019 |