resiniferatoxin and Gagging

resiniferatoxin has been researched along with Gagging* in 1 studies

Other Studies

1 other study(ies) available for resiniferatoxin and Gagging

ArticleYear
Resinferatoxin, an ultrapotent capsaicin analogue, has anti-emetic properties in the ferret.
    Neuropharmacology, 1993, Volume: 32, Issue:8

    Resinferatoxin (100 micrograms/kg, s.c.), the ultrapotent analogue of capsaicin, when given acutely blocked radiation-(200 rads) and copper sulphate (40 mg% 30 ml, p.o.)-induced emesis in ferrets and substantially decreased loperamide (0.5 mg/kg, s.c.)-induced vomiting, without significantly affecting the von Bezold-Jarisch reflex or gag reflex. It also produced a decrease in core temperature as has been reported for capsaicin. The observation that resinferatoxin reduced or blocked emesis induced by both centrally (loperamide) and peripherally (CuSO4, radiation) acting stimuli suggests a novel anti-emetic action that may provide an insight into clinically useful innovative anti-emetics. The mechanism by which resinferatoxin has its anti-emetic effect is at present unknown, although the combination of results from the present study suggest a central site of action involving modulation of release of neurotransmitter, possibly in the nucleus tractus solitarius.

    Topics: Animals; Antiemetics; Behavior, Animal; Blood Pressure; Body Temperature; Capsaicin; Copper; Copper Sulfate; Diterpenes; Dose-Response Relationship, Drug; Female; Ferrets; Gagging; Heart Rate; Loperamide; Male; Radiation Injuries; Reflex; Respiration; Vomiting

1993