resiniferatoxin and Abdominal-Pain

resiniferatoxin has been researched along with Abdominal-Pain* in 1 studies

Other Studies

1 other study(ies) available for resiniferatoxin and Abdominal-Pain

ArticleYear
Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2015, Jan-01, Volume: 308, Issue:1

    Psychological disorders are prevalent in patients with inflammatory bowel disease; the underlying mechanisms remain unknown. We tested the hypothesis that ulcerative colitis-like inflammation induced by dextran sodium sulfate (DSS) exacerbates the ongoing spontaneous activity in colon-projecting afferent neurons that induces abdominal discomfort and anxiety, and depressive-like behaviors in rats. In this study, we used the conditioned place preference and standard tests for anxiety- and depression-like behaviors. DSS rats developed anxiety- and depression-like behaviors 10 to 20 days after the start of inflammation. Single-fiber recordings showed an increase in the frequency of spontaneous activity in L6-S1 dorsal root ganglion (DRG) roots. Prolonged desensitization of transient receptor potential vanilloid 1 (TRPV1)-expressing colonic afferents by resiniferatoxin (RTX) suppressed the spontaneous activity, as well as the anxiety- and depressive-like behaviors. Reduction in spontaneous activity in colon afferents by intracolonic administration of lidocaine produced robust conditioned place preference (CPP) in DSS rats, but not in control rats. Patch-clamp studies demonstrated a significant decrease in the resting membrane potential, lower rheobase, and sensitization of colon-projecting L6-S1 DRG neurons to generate trains of action potentials in response to current injection in DSS rats. DSS inflammation upregulated the mRNA levels of transient receptor potential ankyrin 1 and TRPV1 channels and downregulated that of Kv1.1 and Kv1.4 channels. Ulcerative colitis-like inflammation in rats induces anxiety- and depression-like behaviors, as well as ongoing abdominal discomfort by exacerbating the spontaneous activity in the colon-projecting afferent neurons. Alterations in the expression of voltage- and ligand-gated channels are associated with the induction of mood disorders following colon inflammation.

    Topics: Abdominal Pain; Action Potentials; Anesthetics, Local; Animals; Anxiety; Behavior, Animal; Colitis, Ulcerative; Colon; Conditioning, Psychological; Depression; Dextran Sulfate; Disease Models, Animal; Diterpenes; Ganglia, Spinal; Kv1.1 Potassium Channel; Kv1.4 Potassium Channel; Lidocaine; Rats; RNA, Messenger; Time Factors; TRPV Cation Channels

2015