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reserpine and Ventricular Fibrillation

reserpine has been researched along with Ventricular Fibrillation in 50 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.

Research Excerpts

ExcerptRelevanceReference
"The experiments on anaesthetized dogs have shown that with artificial ventilation and open chest adrenalin in arrhythmogenic and nonarrythmogenic doses enhances glycogenolysis in the heart proportionally to the dose used Block of beta-adrenergic receptors by propranolol decreased the activation of glycogenolysis in the ischaemic zone and the frequency of ventricular fibrillation after occlusion of the coronary artery."7.66[Role of catecholamine in activating glycogenolysis in experimental myocardial infarct complicated by ventricular fibrillation]. ( Dolgova, NP, 1982)
"The experiments on anaesthetized dogs have shown that with artificial ventilation and open chest adrenalin in arrhythmogenic and nonarrythmogenic doses enhances glycogenolysis in the heart proportionally to the dose used Block of beta-adrenergic receptors by propranolol decreased the activation of glycogenolysis in the ischaemic zone and the frequency of ventricular fibrillation after occlusion of the coronary artery."3.66[Role of catecholamine in activating glycogenolysis in experimental myocardial infarct complicated by ventricular fibrillation]. ( Dolgova, NP, 1982)
"The time course of ultrastructural and electrophysiological disorders and their role in sudden death of ventricular fibrillation at various intervals of desympathization caused by reserpine administration were studied."3.66[Effect of reserpine on the ultrastructure and electrical instability of the heart]. ( Beskrovnova, NN; Makarychev, VA; Ul'ianinskiĭ, LS; Vikhert, AM, 1981)
"In perfused rat hearts, ventricular tachycardia (VT), ventricular fibrillation (VF), and accumulation of Ins(1,4,5)P3 were measured during early reperfusion."1.29Suppression of ventricular arrhythmias during ischemia-reperfusion by agents inhibiting Ins(1,4,5)P3 release. ( Anderson, KE; Dart, AM; Du, XJ; Jacobsen, A; Woodcock, EA, 1995)
"Pretreatment with reserpine in six dogs abolished the time dependency."1.26Time dependency of ventricular fibrillation thresholds determined using trains of stimuli. ( Griffin, JC; Jaillon, P; Schnittger, I; Winkle, RA, 1980)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-199046 (92.00)18.7374
1990's2 (4.00)18.2507
2000's2 (4.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Walcott, GP1
Melnick, SB1
Killingsworth, CR1
Smith, WM1
Ideker, RE1
VARMA, DR2
GILLIS, RA1
MELVILLE, KI1
BARRERA, F3
LAUTSCH, EV3
ASCANIO, G3
OPPENHEIMER, MJ3
FEKETE, M1
BORSY, J1
LEE, PK1
ISRAEL, JS1
DOBKIN, AB1
NOLAN, TR1
CORCORAN, AC1
Levitt, B3
Roberts, J3
Wendlandt, S1
Eyer, CL1
Chan, EL1
Dolgova, NP1
Beskrovnova, NN2
Makarychev, VA2
Kiseleva, ZM1
Zhuchkova, NI1
Brooks, WW1
Verrier, RL2
Lown, B2
Ul'ianinskiĭ, LS1
Vikhert, AM1
Li, GF1
Winkle, RA1
Jaillon, P1
Griffin, JC1
Schnittger, I1
Du, XJ1
Anderson, KE1
Jacobsen, A1
Woodcock, EA1
Dart, AM1
Abete, P1
Testa, G1
Ferrara, N1
De Santis, D1
Capaccio, P1
Viati, L1
Calabrese, C1
Cacciatore, F1
Longobardi, G1
Condorelli, M1
Napoli, C1
Rengo, F1
Güttler, K1
Klaus, W1
Land, E1
Kobrin, VI1
Schollmeyer, P1
Wellens, D2
Wauters, E2
Ciofalo, F1
Sakai, K1
Sugano, S1
Isono, C1
Fawaz, G1
Dunlop, D1
Shanks, RG1
Vargaftig, B1
Coignet, JL1
Thompson, PL1
Khitrov, NK1
Aslaniants, ZhK1
Svistukhin, AI1
Stickney, JL2
Meyers, FH1
Lawson, JW1
Sommers, HM1
Jennings, RB1
Das, PK1
Sinha, PS1
Nakano, J1
Mercer, GR1
Kubo, T1
Takagi, H1
Bagchi, N1
Arora, RB1
Singh, M1
Vanderbeek, RB2
Ebert, PA2
Allgood, RJ1
Sabiston, DC1
Hermansen, K1
Cervoni, P1
Ellis, CH1
Maxwell, RA1
Lydtin, H1
Kusus, T1
Dietze, G1
Schnelle, K1
Kaumann, AJ2
Aramendía, P2
Nielsen, KC1
Owman, C1
Popova, NK1
Ivashkevich, EI1
Boyajy, LD1
Nash, CB1

Other Studies

50 other studies available for reserpine and Ventricular Fibrillation

ArticleYear
Effects of burst stimulation during ventricular fibrillation on cardiac function after defibrillation.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Blood

2003
On the relationship of catecholamines and thyroid activity to ventricular fibrillation during hypothermia in dogs.
    Canadian journal of biochemistry and physiology, 1963, Volume: 41

    Topics: Animals; Antithyroid Agents; Catecholamines; Dogs; Epinephrine; Hypothermia; Hypothermia, Induced; I

1963
CARDIOGENIC SHOCK AS INFLUENCED BY RESERPINE.
    The American journal of the medical sciences, 1964, Volume: 247

    Topics: Animals; Cardiovascular Diseases; Catecholamines; Dogs; Myocardial Infarction; Research; Reserpine;

1964
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
    Medicina experimentalis : International journal of experimental medicine, 1964, Volume: 10

    Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound

1964
THE EFFECT OF EPINEPHRINE ON ANAESTHETIZED HYPERTHYROID DOGS PRETREATED WITH RESERPINE AND/OR GUANETHIDINE.
    Canadian Anaesthetists' Society journal, 1964, Volume: 11

    Topics: Anesthesia; Anesthesiology; Dogs; Epinephrine; Guanethidine; Hyperthyroidism; Methoxyflurane; Pharma

1964
EFFECT OF DRUGS ON INDUCED VENTRICULAR FIBRILLATION.
    Lancet (London, England), 1964, Dec-26, Volume: 2, Issue:7374

    Topics: Catecholamines; Coronary Vessels; Dogs; Guanethidine; Myocardium; Pharmacology; Research; Reserpine;

1964
The capacity of different digitalis materials to induce ventricular rhythm disturbances in the reserpine-pretreated cat.
    The Journal of pharmacology and experimental therapeutics, 1967, Volume: 156, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Cats; Digitalis Glycosides; Digitoxin; Digoxin; Female; Lanatosides;

1967
Influence of reserpine, heart failure, and immunosympathectomy on the cardiac effects of ouabain.
    Canadian journal of physiology and pharmacology, 1967, Volume: 45, Issue:4

    Topics: Adrenalectomy; Animals; Blood Pressure; Cats; Female; Heart; Heart Failure; Male; Norepinephrine; Ou

1967
Adrenoceptor influences on pharmacologically induced cardiac arrhythmias.
    Proceedings of the Western Pharmacology Society, 1980, Volume: 23

    Topics: Animals; Arrhythmias, Cardiac; Electrocardiography; Ethanolamines; Isoproterenol; Male; Rats; Recept

1980
[Role of catecholamine in activating glycogenolysis in experimental myocardial infarct complicated by ventricular fibrillation].
    Kardiologiia, 1982, Volume: 22, Issue:7

    Topics: Animals; Arrhythmias, Cardiac; Dogs; Epinephrine; Glycogen; Male; Myocardial Infarction; Myocardium;

1982
[Morphofunctional changes in the myocardium following sympathectomy and their role in the development of sudden death from ventricular fibrillation].
    Vestnik Akademii meditsinskikh nauk SSSR, 1984, Issue:2

    Topics: Animals; Cardiomyopathies; Chinchilla; Death, Sudden; Reserpine; Sympathectomy, Chemical; Ventricula

1984
Extra-adrenergic mechanisms responsible for the effects of glucose-insulin-potassium solution on vulnerability to ventricular fibrillation.
    The American journal of cardiology, 1981, Volume: 47, Issue:2

    Topics: Animals; Coronary Disease; Dogs; Female; Glucose; Insulin; Male; Norepinephrine; Potassium; Proprano

1981
[Effect of reserpine on the ultrastructure and electrical instability of the heart].
    Arkhiv patologii, 1981, Volume: 43, Issue:6

    Topics: Animals; Death, Sudden; Electrocardiography; Heart; Microscopy, Electron; Myocardium; Rabbits; Reser

1981
[Role of catecholamines in the occurrence of ventricular fibrillation (author's transl)].
    Zhonghua xin xue guan bing za zhi, 1981, Volume: 9, Issue:2

    Topics: Animals; Catecholamines; Female; Male; Mice; Reserpine; Ventricular Fibrillation

1981
Time dependency of ventricular fibrillation thresholds determined using trains of stimuli.
    The American journal of physiology, 1980, Volume: 239, Issue:4

    Topics: Animals; Cardiac Pacing, Artificial; Catecholamines; Dogs; Heart Rate; Heart Ventricles; Reserpine;

1980
Suppression of ventricular arrhythmias during ischemia-reperfusion by agents inhibiting Ins(1,4,5)P3 release.
    Circulation, 1995, Jun-01, Volume: 91, Issue:11

    Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Gentamicins; Inositol 1,4,5-Trisp

1995
Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:6

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Aging; Animals; Blood Flow Velocity; Bod

2002
Antagonistic effect of triamterene to ouabain toxicity.
    Arzneimittel-Forschung, 1979, Volume: 29, Issue:4

    Topics: Animals; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium;

1979
[Sympathetic control of spontaneous cardiac defibrillation].
    Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 114, Issue:10

    Topics: Aconitine; Action Potentials; Animals; Catecholamines; Electric Stimulation; Electrocardiography; Gu

1992
[Cardiac rhythm disorders. 2. Therapy].
    Medizinische Klinik, 1971, Apr-23, Volume: 66, Issue:17

    Topics: Adrenergic alpha-Antagonists; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial F

1971
Tyramine-induced modifications of ventricular fibrillation thresholds in the dog: influence of sympatholytic agents.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 201, Issue:2

    Topics: Adrenergic Agents; Animals; Blood Pressure; Bretylium Compounds; Dogs; Ethanolamines; Guanethidine;

1973
Some factors affecting ouabain-induced ventricular arrhythmia in the reserpine-treated cat.
    British journal of pharmacology and chemotherapy, 1967, Volume: 30, Issue:1

    Topics: Adrenalectomy; Animals; Arrhythmias, Cardiac; Body Temperature; Cardiac Complexes, Premature; Cats;

1967
Effects of oxyfedrine and ouabain on the heart-lung preparation of the dog.
    Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 277, Issue:1

    Topics: Amino Alcohols; Animals; Arrhythmias, Cardiac; Cardiac Output; Disease Models, Animal; Dogs; Female;

1973
Effect of quinidine and pronethalol on acetylstrophanthidin-induced ventricular arrhythmia in cats treated with reserpine.
    Circulation research, 1966, Volume: 19, Issue:3

    Topics: Animals; Cardiac Glycosides; Cats; Ethanolamines; Heart Rate; Quinidine; Reserpine; Sinoatrial Node;

1966
Effect of reserpine and pronethalol on the therapeutic and toxic actions of digitalis in the dog heart-lung preparation.
    British journal of pharmacology and chemotherapy, 1967, Volume: 29, Issue:3

    Topics: Animals; Digitoxin; Dogs; Ethanolamines; Heart; Heart Conduction System; Heart Rate; Heart Ventricle

1967
Selective blockade of adrenoceptive beta receptors in the heart.
    British journal of pharmacology and chemotherapy, 1968, Volume: 32, Issue:1

    Topics: Anilides; Animals; Arrhythmias, Cardiac; Blood Circulation; Blood Pressure; Cats; Chloroform; Dogs;

1968
A critical evaluation of three methods for the study of adrenergic beta-blocking and anti-arrhythmic agents.
    European journal of pharmacology, 1969, Volume: 6, Issue:1

    Topics: Aconitum; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bronchi; Chloroform; Constriction;

1969
Modification of ventricular fibrillation thresholds after sympatholytic drugs in the dog.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 198, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Depression, Chemi

1972
Ventricular vulnerability during sympathetic stimulation: role of heart rate and blood pressure.
    Cardiovascular research, 1974, Volume: 8, Issue:5

    Topics: Animals; Blood Pressure; Denervation; Dogs; Electric Stimulation; Electrocardiography; Electrodes; F

1974
[Role of the sympathetic-adrenal system in the mechanisms of genesis of cardiac fibrillation induced by calcium chloride].
    Kardiologiia, 1974, Volume: 14, Issue:6

    Topics: Adrenal Glands; Animals; Blood Pressure; Calcium; Calcium Chloride; Epinephrine; Male; Myocardium; N

1974
Digitalis toxicity. Development of cardiac arrhythmias in spontaneously breathing vs. artificially respired dogs.
    American heart journal, 1973, Volume: 85, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Dogs; Electrocardiography; Heart; Heart Arrest; Heart Rate; Male; Oua

1973
The effect of reserpine and d,l-propranolol on digitalis-induced arrhythmias.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 201, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Cardanolides; Disease Models, Animal; Dogs;

1973
Antiarrhythmic activity of some isoquinoline derivatives determined by a rapid screening procedure in the mouse.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 160, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Atropine; Chloroform; Diphenhydramine; Electrocardiography; Female;

1968
Ventricular fibrillation and myocardial necrosis after transient ischemia. Effect of treatment with oxygen, procainamide, reserpine, and propranolol.
    Archives of internal medicine, 1972, Volume: 129, Issue:5

    Topics: Animals; Coronary Disease; Dogs; Injections, Intra-Arterial; Injections, Intramuscular; Injections,

1972
Effect of physostigmine on ventricular fibrillation and myocardial glycogen in hypothermic dogs.
    British journal of pharmacology, 1972, Volume: 44, Issue:3

    Topics: Animals; Atropine; Blood Pressure; Coronary Vessels; Dogs; Glycogen; Heart Atria; Heart Rate; Heart

1972
Circulatory effect of ventricular fibrillation.
    Acta cardiologica, 1965, Volume: 20, Issue:6

    Topics: Animals; Blood Circulation; Cardiac Output; Dogs; Electric Countershock; Heart Massage; Phenoxybenza

1965
A possible mechanism of arrhythmia induced by 1-adamantanamine.
    Japanese journal of pharmacology, 1967, Volume: 17, Issue:4

    Topics: Amantadine; Animals; Arrhythmias, Cardiac; Catecholamines; Cocaine; Electrocardiography; Female; Gui

1967
Antagonism to ouabain induced ventricular fibrillation; action of reserpine, propranolol, INPEA and quinidine.
    Japanese journal of pharmacology, 1969, Volume: 19, Issue:4

    Topics: Amino Alcohols; Animals; Drug Antagonism; Female; Guinea Pigs; Male; Ouabain; Phenethylamines; Propr

1969
Factors in acute hypotension and ventricular fibrillation after cardiac necrosis.
    The American journal of the medical sciences, 1967, Volume: 253, Issue:6

    Topics: Animals; Atropine; Blood Pressure; Bradycardia; Catecholamines; Dogs; Dye Dilution Technique; Electr

1967
Potassium release in the denervated heart.
    The American journal of physiology, 1970, Volume: 218, Issue:3

    Topics: Animals; Catecholamines; Coronary Vessels; Denervation; Dogs; Heart; Myocardium; Neuromuscular Depol

1970
Effect of chronic cardiac denervation on arrhythmias after coronary artery ligation.
    Cardiovascular research, 1970, Volume: 4, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Catecholamines; Coronary Vessels; Denervation; Dogs;

1970
Evidence for adrenergic mediation of ouabain induced arrhythmias in the guinea pig.
    Acta pharmacologica et toxicologica, 1970, Volume: 28, Issue:1

    Topics: Adrenalectomy; Animals; Arrhythmias, Cardiac; Electrocardiography; Guinea Pigs; Male; Norepinephrine

1970
The anti-arrhythmic action of bretylium in normal reserpine-pretreated and chronically denervated dog hearts.
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 190, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Denervation; Dogs; Electric Stimulation; Heart

1971
[Effect of an adrenergic beta-receptor-blocking agent on cardiac rhythm disturbances in experimental barium poisoning].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; Atropine; Barium; Dogs; Female; Male; Myocardium; Potassium; Proprano

1967
Prevention of ventricular fibrillation induced by coronary ligation.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 164, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Vessels; Dogs; Heart Atria; Heart Rate; In

1968
Effect of reserpine on the spontaneous ventriculae fibrillation development during iduced deep hypothermia in cats.
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 175, Issue:2

    Topics: Animals; Blood Pressure; Body Temperature; Cats; Electroencephalography; Epinephrine; Female; Fluoro

1968
Role of reflexes following myocardial necrobiosis.
    The American journal of physiology, 1965, Volume: 209, Issue:6

    Topics: Animals; Atropine; Collateral Circulation; Dogs; Femoral Artery; Hydrocarbons, Halogenated; Myocardi

1965
[Pharmacologic prevention of fibrillation in acute ischemia of the heart and the dynamics of electrolytes].
    Biulleten' eksperimental'noi biologii i meditsiny, 1965, Volume: 59, Issue:5

    Topics: Animals; Coronary Disease; Coronary Vessels; Dogs; Electrolytes; Isoniazid; Monoamine Oxidase Inhibi

1965
Alteration of ouabain taxicity by cardiac denervation.
    Toxicology and applied pharmacology, 1966, Volume: 9, Issue:2

    Topics: Anesthesia, Spinal; Animals; Chlorisondamine; Denervation; Dogs; Electrocardiography; Heart Conducti

1966
Inhibition of ventricular fibrillation induced by ouabain.
    Acta physiologica latino americana, 1966, Volume: 16, Issue:4

    Topics: Animals; Guinea Pigs; Ouabain; Reserpine; Sympatholytics; Ventricular Fibrillation

1966