reserpine has been researched along with Substance Withdrawal Syndrome in 49 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 74-year-old woman developed a slowly progressive hemichorea starting 3 weeks after discontinuation of low-dose amitriptyline and perphenazine." | 7.67 | A case of progressive hemichorea responsive to high-dose reserpine. ( Friedman, JH, 1986) |
| "The suitability of the zebrafish model of anhedonia using reserpine and fluoxetine was evaluated." | 4.31 | Fluoxetine rescues the depressive-like behaviour induced by reserpine and the altered emotional behaviour induced by nicotine withdrawal in zebrafish: Involvement of tyrosine hydroxylase. ( Braida, D; Dellarole, I; Morara, S; Ponzoni, L; Sala, M, 2023) |
| "A 74-year-old woman developed a slowly progressive hemichorea starting 3 weeks after discontinuation of low-dose amitriptyline and perphenazine." | 3.67 | A case of progressive hemichorea responsive to high-dose reserpine. ( Friedman, JH, 1986) |
| "A case is reported in which abrupt cessation of long term reserpine therapy for hypertension was followed by hallucinations and mania." | 3.66 | Reserpine withdrawal psychosis: the possible role of denervation supersensitivity of receptors. ( Kent, TA; Wilber, RD, 1982) |
| "Depression was assessed using the CES-D scale (Center for Epidemiological Studies--Depressed Mood), administered at baseline and again approximately 1 year after randomization." | 2.67 | Effect of withdrawal of antihypertensive drug on depressive mood. ( Blaufox, MD; Langford, HG; Oberman, A; Thaler, L; Wassertheil-Smoller, S, 1993) |
| "Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2) and monoamine releaser, so it can be used as a pharmacological model of depression." | 1.42 | Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. ( Antkiewicz-Michaluk, L; Michaluk, J; Możdżeń, E; Romańska, I; Wąsik, A, 2015) |
| "Reserpine (Res) was used to deplete central noradrenaline." | 1.29 | Influences of locus coeruleus lesions and reserpine treatment on opioid physical dependence in rats. ( Miao, H; Qin, BY, 1995) |
| "Reserpine pretreatment eliminated the differences between control and withdrawn animals." | 1.26 | Effects of withdrawal from chronic amphetamine intoxication on exploratory and stereotyped behaviors in the rat. ( Hitzemann, BA; Hitzemann, RJ; Loh, HH; Sampath-Khanna, S; Tseng, LF, 1977) |
| "Mice were given several atropine injections at a high dosage level." | 1.25 | Sensitivity changes to morphine and other drugs induced by cholinergic blockade. ( Contreras, E; Quijada, L; Tamayo, L, 1975) |
| "C57BL mice showed almost no convulsions on handling." | 1.25 | Alcohol withdrawal convulsions in genetically different populations of mice. ( Goldstein, DB; Kakihana, R, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (81.63) | 18.7374 |
| 1990's | 5 (10.20) | 18.2507 |
| 2000's | 2 (4.08) | 29.6817 |
| 2010's | 1 (2.04) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Braida, D | 1 |
| Ponzoni, L | 1 |
| Dellarole, I | 1 |
| Morara, S | 1 |
| Sala, M | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Wąsik, A | 1 |
| Możdżeń, E | 1 |
| Romańska, I | 1 |
| Michaluk, J | 1 |
| Ligeiro de Oliveira, AP | 1 |
| Lazzarini, R | 1 |
| Cavriani, G | 1 |
| Quinteiro-Filho, WM | 1 |
| Tavares de Lima, W | 1 |
| Palermo-Neto, J | 1 |
| CIANI, N | 1 |
| DONINI, G | 1 |
| Broadley, KJ | 1 |
| Williams, RG | 1 |
| Hawthorn, MH | 1 |
| Grassby, PF | 1 |
| Murrin, LC | 1 |
| Kennedy, RH | 1 |
| Donnelly, TE | 1 |
| Johnson, JM | 1 |
| Bacher, NM | 1 |
| Lewis, HA | 1 |
| Tagashira, E | 1 |
| Hiramori, T | 1 |
| Nakao, K | 1 |
| Urano, T | 1 |
| Yanaura, S | 1 |
| López, E | 1 |
| Luján, M | 1 |
| Rodríguez, R | 1 |
| Dilsaver, SC | 1 |
| Greden, JF | 1 |
| Kent, TA | 1 |
| Wilber, RD | 1 |
| Miao, H | 1 |
| Qin, BY | 1 |
| Thaler, L | 1 |
| Wassertheil-Smoller, S | 1 |
| Blaufox, MD | 1 |
| Oberman, A | 1 |
| Langford, HG | 1 |
| Webster, J | 1 |
| Koch, HF | 1 |
| Simpson, GM | 1 |
| Belknap, JK | 1 |
| Casey, DE | 1 |
| Smith, RA | 1 |
| Winter, PM | 1 |
| Smith, M | 1 |
| Eger, EI | 1 |
| Kruszewska, A | 1 |
| Langwiński, R | 1 |
| Hitzemann, RJ | 1 |
| Tseng, LF | 1 |
| Hitzemann, BA | 1 |
| Sampath-Khanna, S | 1 |
| Loh, HH | 1 |
| Symes, AL | 1 |
| Lal, S | 1 |
| Young, SN | 1 |
| Tsang, D | 1 |
| Sourkes, TL | 1 |
| Gibson, A | 3 |
| Pollock, D | 4 |
| Contreras, E | 1 |
| Tamayo, L | 1 |
| Quijada, L | 1 |
| Goldstein, DB | 4 |
| Kakihana, R | 2 |
| Colasanti, BK | 1 |
| Kosa, JE | 1 |
| Craig, CR | 1 |
| Koyuncuoglu, H | 1 |
| Güngör, M | 1 |
| Bhat, RV | 1 |
| Worley, PF | 1 |
| Cole, AJ | 1 |
| Baraban, JM | 1 |
| Ahlenius, S | 1 |
| Ericson, EL | 1 |
| Högberg, K | 1 |
| Wijkström, A | 1 |
| Stasiek, C | 1 |
| Zetin, M | 1 |
| Samuels, AH | 1 |
| Taylor, AJ | 1 |
| Nabeshima, T | 1 |
| Yamaguchi, K | 1 |
| Yoshida, S | 1 |
| Furukawa, H | 1 |
| Kameyama, T | 1 |
| Friedman, JH | 1 |
| Hansson, L | 2 |
| Hunyor, SN | 2 |
| Oswald, I | 1 |
| Hartmann, E | 1 |
| Norton, PR | 1 |
| Kamei, C | 1 |
| Shimomura, K | 1 |
| Ueki, S | 1 |
| Segal, M | 1 |
| Deneau, GA | 1 |
| Seevers, MH | 1 |
| Muir, TC | 1 |
| MacDonald, A | 1 |
| Henderson, G | 1 |
| Julius, S | 1 |
| Hoobler, SW | 1 |
| Storm-Mathisen, H | 1 |
| Iwamoto, ET | 1 |
| Ho, IK | 1 |
| Way, EL | 1 |
| Gunne, LM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00005464] | 0 participants | Observational | 1991-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for reserpine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Mechanisms of cardiac supersensitivity to sympathomimetic amines.
Topics: Animals; Guinea Pigs; Heart; Humans; Hydroxydopamines; Isoproterenol; Metaproterenol; Oxidopamine; R | 1984 |
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 1984 |
Aspects of tolerability of centrally acting antihypertensive drugs.
Topics: Antihypertensive Agents; Clonidine; Humans; Imidazoles; Methyldopa; Reserpine; Substance Withdrawal | 1996 |
The treatment of tardive dyskinesia and tardive dystonia.
Topics: Adult; Akathisia, Drug-Induced; Algorithms; Antipsychotic Agents; Benzodiazepines; Clozapine; Decisi | 2000 |
Sleep, natural and unnatural.
Topics: Amphetamine; Antidepressive Agents; Barbiturates; Brain Chemistry; Dreams; Electroconvulsive Therapy | 1969 |
4 trials available for reserpine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 1984 |
Effect of withdrawal of antihypertensive drug on depressive mood.
Topics: Affect; Antihypertensive Agents; Depression; Female; Humans; Hypertension; Male; Middle Aged; Psychi | 1993 |
Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management.
Topics: Adult; Blood Pressure; Catecholamines; Clonidine; Female; Humans; Hypertension; Male; Middle Aged; P | 1973 |
[The danger of sudden withdrawal of Catapresan].
Topics: Blood Pressure; Clonidine; Humans; Placebos; Reserpine; Substance Withdrawal Syndrome | 1973 |
41 other studies available for reserpine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Fluoxetine rescues the depressive-like behaviour induced by reserpine and the altered emotional behaviour induced by nicotine withdrawal in zebrafish: Involvement of tyrosine hydroxylase.
Topics: Anhedonia; Animals; Calcitonin Gene-Related Peptide; Fluoxetine; Nicotine; Reserpine; Substance With | 2023 |
Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat.
Topics: Animals; Brain; Dopamine; In Vitro Techniques; Male; Motor Activity; Norepinephrine; Rats; Receptors | 2015 |
Effects of single or repeated amphetamine treatment and withdrawal on lung allergic inflammation in rats.
Topics: Alveolitis, Extrinsic Allergic; Amphetamine; Animals; Antipsychotic Agents; Bone Marrow Cells; Bronc | 2008 |
[ON THERAPEUTIC EFFICACY OF SUDDEN SUSPENSION OF PROLONGED THERAPY WITH ASSOCIATED RESERPINE AND CHLORPROMAZINE IN SCHIZOPHRENIC SUBJECTS].
Topics: Chlorpromazine; Drug Therapy; Haloperidol; Humans; Phenothiazines; Reserpine; Schizophrenia; Substan | 1965 |
Effect of withdrawal from chronic propranolol treatment on high-affinity choline uptake in rat brain.
Topics: Animals; Brain; Choline; Humans; Male; Propranolol; Rats; Rats, Inbred Strains; Reserpine; Substance | 1983 |
Reserpine and tardive dyskinesia.
Topics: Acute Disease; Antipsychotic Agents; Dyskinesia, Drug-Induced; Humans; Reserpine; Substance Withdraw | 1984 |
Effects of central monoamine compounds on tranylcypromine-induced barbital-withdrawal convulsions.
Topics: alpha-Methyltyrosine; Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Humans; Mal | 1983 |
Possible involvement of neural substances in the abstinence like response of the guinea-pig ileum stimulated electrically at high frequency.
Topics: Acetylcholine; Animals; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Muscle, Smoo | 1983 |
Possible cholinergic mechanism in reserpine and tardive dyskinesia.
Topics: Corpus Striatum; Dyskinesia, Drug-Induced; Humans; Receptors, Dopamine; Receptors, Muscarinic; Reser | 1984 |
Reserpine withdrawal psychosis: the possible role of denervation supersensitivity of receptors.
Topics: Affective Disorders, Psychotic; Aged; Basal Ganglia; Bipolar Disorder; Dopamine; Female; Hallucinati | 1982 |
Influences of locus coeruleus lesions and reserpine treatment on opioid physical dependence in rats.
Topics: Animals; Body Weight; Etorphine; Female; Locus Coeruleus; Male; Morphine Dependence; Neurons; Opioid | 1995 |
Barbiturate physical dependence in mice: effects of neuroleptics and diazepam on the withdrawal syndrome.
Topics: Animals; Antipsychotic Agents; Barbiturates; Chlorpromazine; Diazepam; Haloperidol; Humans; Male; Me | 1978 |
Managing tardive dyskinesia.
Topics: Antipsychotic Agents; Choline; Deanol; Dyskinesia, Drug-Induced; Humans; Lithium; Receptors, Dopamin | 1978 |
Convulsions in mice after anesthesia.
Topics: Anesthetics; Animals; Cyclopropanes; Ether; Ethers; Ethylenes; Humans; Methyldopa; Mice; Mice, Inbre | 1979 |
[The effect of reserpine on the morphine abstinence syndrome in mice (author's transl)].
Topics: 5-Hydroxytryptophan; Animals; Drug Antagonism; Humans; Levodopa; Male; Mice; Morphine Dependence; Re | 1979 |
Effects of withdrawal from chronic amphetamine intoxication on exploratory and stereotyped behaviors in the rat.
Topics: Animals; Apomorphine; Behavior; Dextroamphetamine; Exploratory Behavior; Humans; Male; Methyltyrosin | 1977 |
Effect of chronic chlorpromazine administration or prior treatment with reserpine on brain apomorphine concentrations and apomorphine-induced sterotyped behaviour in the rat.
Topics: Animals; Apomorphine; Behavior; Brain Chemistry; Chlorpromazine; Drug Interactions; Humans; Male; Mo | 1977 |
The involvement of corticosteroids in the supersensitivity produced in the rat anococcygeus muscle by morphine withdrawal, thyroidectomy or a single dose of reserpine.
Topics: Acetylcholine; Adrenalectomy; Animals; Body Weight; Corticosterone; Humans; In Vitro Techniques; Mal | 1975 |
Sensitivity changes to morphine and other drugs induced by cholinergic blockade.
Topics: Amphetamine; Analgesics; Animals; Arecoline; Atropine; Drug Tolerance; Female; Hexobarbital; Humans; | 1975 |
Alcohol withdrawal convulsions in genetically different populations of mice.
Topics: Alcoholism; Animals; Breeding; Ethanol; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred | 1975 |
Reduction in the cholinesterase activity of the rat anococcygeus muscle produced by corticosterone.
Topics: Adrenal Glands; Adrenalectomy; Animals; Cholinesterases; Corticosterone; Depression, Chemical; Human | 1975 |
Appearance of wet dog shake behavior during cobalt experimental epilepsy in the rat and its suppression by reserpine.
Topics: Animals; Cobalt; Drug Implants; Electroencephalography; Electromyography; Female; Humans; Parietal L | 1975 |
Effect of nialamide and reserpine on brain free amino acids of rat dependent on and withdrawn from morphine.
Topics: Amino Acids; Animals; Body Weight; Brain; Brain Chemistry; Humans; Morphine Dependence; Nialamide; R | 1975 |
Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268.
Topics: Animals; Apomorphine; Benzazepines; Brain; DNA-Binding Proteins; Early Growth Response Protein 1; Ea | 1992 |
Behavioural and biochemical effects of subchronic treatment with raclopride in the rat: tolerance and brain monoamine receptor sensitivity.
Topics: Animals; Apomorphine; Brain; Dihydroxyphenylalanine; Dopamine Antagonists; Drug Tolerance; Male; Mot | 1991 |
Organic manic disorders.
Topics: Adrenal Cortex Hormones; Adult; Antidepressive Agents, Tricyclic; Bipolar Disorder; Bronchodilator A | 1985 |
Reserpine withdrawal psychosis.
Topics: Aged; Female; Humans; Hypertension; Psychoses, Substance-Induced; Reserpine; Substance Withdrawal Sy | 1989 |
Phencyclidine-induced wet-dog shakes observed in rats after withdrawal from reserpine treatment.
Topics: Animals; Behavior, Animal; Imipramine; Male; Mianserin; p-Chloroamphetamine; Phencyclidine; Rats; Ra | 1986 |
A case of progressive hemichorea responsive to high-dose reserpine.
Topics: Aged; Amitriptyline; Chorea; Dyskinesia, Drug-Induced; Female; Humans; Perphenazine; Reserpine; Subs | 1986 |
Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.
Topics: 5-Hydroxytryptophan; Acetates; Aminobutyrates; Animals; Atropine; Ethanol; Fenclonine; Humans; Male; | 1973 |
Blood pressure over-shoot due to acute clonidine (Catapres) withdrawal: studies on arterial and urinary catecholamines and suggestions for management of the crisis.
Topics: Acetanilides; Adrenergic beta-Antagonists; Amino Alcohols; Catecholamines; Clonidine; Headache; Huma | 1973 |
A note on the nightmare.
Topics: Anxiety; Arousal; Dreams; Female; Fever; Humans; Male; Reserpine; Sleep; Sleep Deprivation; Sleep, R | 1970 |
The effects of drugs on barbiturate withdrawal convulsions in the rat.
Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Ethanol; Ethosuximide; Female; Humans; Hydr | 1970 |
Significance of withdrawal jumping response in predicting physical dependence in mice.
Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imip | 1973 |
Alcohol withdrawal reactions and reserpine effects in inbred strains of mice.
Topics: Animals; Ethanol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbre | 1974 |
Levels and distribution of central nervous system amines in normal and morphine-dependent monkeys.
Topics: Animals; Behavior, Animal; Brain Chemistry; Caudate Nucleus; Cerebellum; Cerebral Cortex; Dopamine; | 1972 |
Morphine-induced changes in the sensitivity of the isolated colon and vas deferens of the rat.
Topics: Acetylcholine; Animals; Atropine; Colon; Dose-Response Relationship, Drug; Furans; Humans; In Vitro | 1972 |
Convulsions elicited by handling: a sensitive method of measuring CNS excitation in mice treated with reserpine or convulsant drugs.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Ethanol; Humans; Male; Mice; Pent | 1973 |
Elevation of brain dopamine during naloxone-precipitated withdrawal in morphine-dependent mice and rats.
Topics: Animals; Atropine; Brain; Brain Stem; Cerebellum; Corpus Striatum; Dopamine; Humans; Hypothalamus; M | 1973 |
Proceedings: The involvement of corticosteroids in the supersensitivity produced in the rat anococcygeus muscle by morphine withdrawal or reserpine.
Topics: Adrenal Cortex Hormones; Animals; Drug Hypersensitivity; Humans; Male; Metyrapone; Morphine; Muscles | 1974 |
Some pharmacological agents modifying the morphine abstinence syndrome in dogs.
Topics: Animals; Dihydroxyphenylalanine; Dogs; Drug Tolerance; Humans; Methyldopa; Methyltyrosines; Morphine | 1965 |