reserpine has been researched along with Pulmonary Fibrosis in 3 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of a course treatment with a sympatholytic reserpine on the inflammatory response and connective tissue proliferation in the lungs of C57Bl/6 mice was studied on the model of toxic pulmonary fibrosis induced by intratracheal administration of bleomycin." | 3.78 | Mechanisms of the anti-inflammatory and antifibrotic activity of a sympatholytic agent during toxic pulmonary fibrosis. ( Andreeva, TV; Dygai, AM; Ermakova, NN; Ermolaeva, LA; Khmelevskaya, ES; Krupin, VA; Pershina, OV; Reztsova, AM; Skurikhin, EG; Stepanova, IE, 2012) |
| "Reserpine has been shown to inhibit expression of cell-mediated immune responses in mice, probably by causing intercellular release and degradation of vasoactive amines." | 1.27 | The pathogenesis of interstitial pneumonitis induced by trehalose dimycolate. II. Reserpine prevents formation of lesions. ( Goren, MB; Kirkpatrick, CH; Seggev, JS, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Skurikhin, EG | 1 |
| Khmelevskaya, ES | 1 |
| Pershina, OV | 1 |
| Andreeva, TV | 1 |
| Ermolaeva, LA | 1 |
| Krupin, VA | 1 |
| Ermakova, NN | 1 |
| Reztsova, AM | 1 |
| Stepanova, IE | 1 |
| Dygai, AM | 1 |
| Seggev, JS | 1 |
| Kirkpatrick, CH | 1 |
| Goren, MB | 1 |
| Kawabata, S | 1 |
3 other studies available for reserpine and Pulmonary Fibrosis
| Article | Year |
|---|---|
Mechanisms of the anti-inflammatory and antifibrotic activity of a sympatholytic agent during toxic pulmonary fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Bleomycin; Colony-Forming Units Assay; Granulocyte-Macrophage Pro | 2012 |
The pathogenesis of interstitial pneumonitis induced by trehalose dimycolate. II. Reserpine prevents formation of lesions.
Topics: Animals; Cord Factors; Dose-Response Relationship, Drug; Glycolipids; Immunity, Cellular; Mice; Mice | 1984 |
[Effects of reserpine on respiratory functions, with special reference to the increase of anoxemia in cardiac and pulmonary diseases].
Topics: Aortic Valve Stenosis; Asthma; Blood Gas Analysis; Bronchiectasis; Bronchitis; Carbon Dioxide; Cardi | 1968 |