reserpine has been researched along with Obesity in 28 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a controlled study (the control group receiving pyribenzamine) it was observed that reserpine, in the dosage used, had no effect on weight loss in patients receiving d-amphetamine sulphate (Dexedrine(R)) and methyl cellulose (Cellothyl(R)) while on 1,000-calorie diets as compared with the control group." | 7.64 | Reserpine in weight reduction. The effect in obese patients on 1,000-calorie diets: a controlled study. ( SMITH, MC, 1959) |
| "Obesity is associated with low-grade chronic inflammation and oxidative stress, affecting the brain's reward system by decreasing dopaminergic neurotransmission." | 5.72 | Effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced Parkinson's disease. ( Andrade, VM; Bitencourt, RM; Cavalheiro, EKFF; Cucker, L; da Silva, LE; Dal-Pizzol, F; Damiani, AP; Joaquim, L; Machado, RS; Magenis, ML; Michels, M; Oliveira, MP; Petronilho, F; Rezin, GT; Ribeiro, CB; Silva, MG; Tuon, T; Vilela, TC, 2022) |
| "Reserpine use was examined for yearly use by each year preceding the diagnosis of breast cancer, by cumulative yearly use, and by other defined time periods." | 5.25 | Matched-pairs study of reserpine use and breast cancer. ( Fischer, S; Laska, EM; Meisner, M; Siegel, C; Wanderling, J, 1975) |
| "Effect of reserpine on body weight (BW), feed intake (FI), brain and plasma catecholamine and indoleamine concentrations in high- (HWS) and low- (LWS) weight selected lines of chickens was investigated." | 3.73 | Differential autonomic nervous system response in obese and anorexic chickens (Gallus gallus). ( Denbow, DM; Kuo, AY; Lee, JC; Magnin, G; Siegel, PB, 2006) |
| "We compared the effects of long-term treatment with the angiotensin-converting enzyme inhibitor perindopril and triple therapy (hydrochlorothiazide, reserpine, and hydralazine) on the metabolic and renal features in the SHR/N-corpulent (cp) rat, a genetic model of non-insulin-dependent diabetes mellitus and hypertension." | 3.69 | Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulent rat. ( Abraham, AA; Michaelis, OE; Scalbert, E; Striffler, JS; Thibault, N; Velasquez, MT, 1997) |
| "In a controlled study (the control group receiving pyribenzamine) it was observed that reserpine, in the dosage used, had no effect on weight loss in patients receiving d-amphetamine sulphate (Dexedrine(R)) and methyl cellulose (Cellothyl(R)) while on 1,000-calorie diets as compared with the control group." | 3.64 | Reserpine in weight reduction. The effect in obese patients on 1,000-calorie diets: a controlled study. ( SMITH, MC, 1959) |
| "Obesity is associated with low-grade chronic inflammation and oxidative stress, affecting the brain's reward system by decreasing dopaminergic neurotransmission." | 1.72 | Effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced Parkinson's disease. ( Andrade, VM; Bitencourt, RM; Cavalheiro, EKFF; Cucker, L; da Silva, LE; Dal-Pizzol, F; Damiani, AP; Joaquim, L; Machado, RS; Magenis, ML; Michels, M; Oliveira, MP; Petronilho, F; Rezin, GT; Ribeiro, CB; Silva, MG; Tuon, T; Vilela, TC, 2022) |
| "In order to examine the effect of treatment of mild hypertension of the aged, a 4 year prospective trial was performed in 41 placebo and 38 drug-treated patients with an average age of 76." | 1.27 | The treatment of mild hypertension in the elderly, a prospective study using multiple regression analysis. ( Kuramoto, K; Matsushita, S, 1985) |
| "Reserpine use was examined for yearly use by each year preceding the diagnosis of breast cancer, by cumulative yearly use, and by other defined time periods." | 1.25 | Matched-pairs study of reserpine use and breast cancer. ( Fischer, S; Laska, EM; Meisner, M; Siegel, C; Wanderling, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (89.29) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 1 (3.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalheiro, EKFF | 1 |
| da Silva, LE | 1 |
| Oliveira, MP | 1 |
| Silva, MG | 1 |
| Damiani, AP | 1 |
| Ribeiro, CB | 1 |
| Magenis, ML | 1 |
| Cucker, L | 1 |
| Michels, M | 1 |
| Joaquim, L | 1 |
| Machado, RS | 1 |
| Vilela, TC | 1 |
| Bitencourt, RM | 1 |
| Andrade, VM | 1 |
| Dal-Pizzol, F | 1 |
| Petronilho, F | 1 |
| Tuon, T | 1 |
| Rezin, GT | 1 |
| KINARD, S | 2 |
| MILLS, LC | 2 |
| MOYER, JH | 2 |
| TERRELL, J | 2 |
| KROGSGAARD, AR | 1 |
| SMITH, MC | 1 |
| ALBEAUX-FERNET, M | 1 |
| SCHWARTZ, W | 1 |
| TURNER, RW | 1 |
| MILLIGAN, J | 1 |
| HUGHES, RG | 1 |
| Kuo, AY | 1 |
| Lee, JC | 1 |
| Magnin, G | 1 |
| Siegel, PB | 1 |
| Denbow, DM | 1 |
| Hays, SE | 1 |
| Goodwin, FK | 1 |
| Paul, SM | 1 |
| Milovidova, SS | 1 |
| Liakhova, TM | 1 |
| Velasquez, MT | 1 |
| Striffler, JS | 1 |
| Abraham, AA | 1 |
| Michaelis, OE | 1 |
| Scalbert, E | 1 |
| Thibault, N | 1 |
| Laska, EM | 1 |
| Siegel, C | 1 |
| Meisner, M | 1 |
| Fischer, S | 1 |
| Wanderling, J | 1 |
| Giovannini, C | 1 |
| Sellini, M | 1 |
| Marchesi, L | 1 |
| Fierro, A | 1 |
| Massimiani, F | 1 |
| Levin, ML | 1 |
| Thomas, DB | 1 |
| Hickler, RB | 1 |
| Rahman, JC | 1 |
| Drumheller, GH | 1 |
| Dawson, R | 1 |
| Callahan, MF | 1 |
| Annau, Z | 1 |
| Kuramoto, K | 1 |
| Matsushita, S | 1 |
| Waal-Manning, HJ | 1 |
| Simpson, FO | 1 |
| Ryvkin, IA | 1 |
| Korsunskiĭ, AA | 1 |
| Pribylova, LP | 1 |
| Lobanova, LS | 1 |
| Raĭskaia, AM | 1 |
| Mise, J | 1 |
| Hellman, B | 1 |
| Lernmark, A | 2 |
| Sehlin, J | 1 |
| Täljedal, IB | 1 |
| Negoita, CJ | 1 |
| Saiduddin, S | 1 |
| Bray, GA | 1 |
| York, DA | 1 |
| Swerdloff, RS | 1 |
1 review available for reserpine and Obesity
| Article | Year |
|---|---|
Pulmonary hypertension.
Topics: Adult; Aging; Cardiac Output; Chronic Disease; Electrocardiography; Humans; Hypertension, Pulmonary; | 1974 |
1 trial available for reserpine and Obesity
| Article | Year |
|---|---|
Fenfluramine in obese patients on various antihypertensive drugs. Double-blind controlled trial.
Topics: Antihypertensive Agents; Appetite Depressants; Blood Glucose; Blood Pressure; Body Weight; Cholester | 1969 |
26 other studies available for reserpine and Obesity
| Article | Year |
|---|---|
Effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced Parkinson's disease.
Topics: Animals; Disease Models, Animal; Inflammation; Obesity; Oxidative Stress; Parkinson Disease; Reserpi | 2022 |
Use of d-amphetamine to curb the increased appetite and over-eating induced by reserpine therapy.
Topics: Amphetamine; Amphetamines; Appetite; Autonomic Nervous System Diseases; Dextroamphetamine; Feeding a | 1956 |
Use of d-amphetamine to curb the increased appetite and over-eating induced by reserpine therapy.
Topics: Amphetamine; Amphetamines; Appetite; Autonomic Nervous System Diseases; Dextroamphetamine; Feeding a | 1956 |
Use of d-amphetamine to curb the increased appetite and over-eating induced by reserpine therapy.
Topics: Amphetamine; Amphetamines; Appetite; Autonomic Nervous System Diseases; Dextroamphetamine; Feeding a | 1956 |
Use of d-amphetamine to curb the increased appetite and over-eating induced by reserpine therapy.
Topics: Amphetamine; Amphetamines; Appetite; Autonomic Nervous System Diseases; Dextroamphetamine; Feeding a | 1956 |
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression.
Topics: Depression; Depressive Disorder; Essential Hypertension; Humans; Hypertension; Obesity; Reserpine; W | 1958 |
Reserpine in weight reduction. The effect in obese patients on 1,000-calorie diets: a controlled study.
Topics: Dextroamphetamine; Diet, Reducing; Humans; Obesity; Reserpine; Weight Loss | 1959 |
[THE ROUTE OF AN OBESE WOMAN HAPPILY CHANGED THROUGH A WELL-FOLLOWED ITINERARY].
Topics: Diet, Reducing; Female; Happiness; Humans; Mineral Waters; Obesity; Reserpine | 1963 |
MEBUTAMATE AND HYDROCHLOROTHIAZIDE IN HYPERTENSION.
Topics: Antihypertensive Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure Determination; Carbamates; | 1964 |
HYPERTENSION AND ITS COMPLICATIONS. 2.
Topics: Amobarbital; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Cold Temperature | 1964 |
Obesity--an approach to the problem with methamphetamine-reserpine combined therapy.
Topics: Amphetamine; Amphetamines; Humans; Methamphetamine; Obesity; Psychotherapy, Multiple; Reserpine | 1960 |
Differential autonomic nervous system response in obese and anorexic chickens (Gallus gallus).
Topics: Animal Feed; Animals; Anorexia; Autonomic Nervous System; Body Weight; Brain; Catecholamines; Chicke | 2006 |
Cholecystokinin receptors in brain: effects of obesity, drug treatment, and lesions.
Topics: Amphetamine; Animals; Brain; Caudate Nucleus; Fasting; Humans; Huntington Disease; In Vitro Techniqu | 1981 |
[Effectiveness of different methods of treatment for obesity and arterial hypertension].
Topics: Combined Modality Therapy; Female; Hemodynamics; Humans; Hypertension; Middle Aged; Obesity; Reserpi | 1983 |
Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulent rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Diabetes Mellitus, Type | 1997 |
Matched-pairs study of reserpine use and breast cancer.
Topics: Aged; Breast Neoplasms; Diagnosis, Computer-Assisted; Family Characteristics; Female; Hospital Recor | 1975 |
[Behavior of plasma cortisol during testing with insulin and with LVP in obese subjects compared to normal subjects after resperine administration].
Topics: Humans; Hydrocortisone; Insulin; Lypressin; Obesity; Reserpine | 1979 |
The epidemiology of breast cancer.
Topics: Adult; Age Factors; Aged; Breast Diseases; Breast Neoplasms; Dietary Fats; Estrogens; Ethnicity; Fem | 1977 |
The office management of hypertension.
Topics: Adult; Age Factors; Ambulatory Care; Antihypertensive Agents; Benzothiadiazines; Black or African Am | 1975 |
Hypertension.
Topics: Antihypertensive Agents; Benzothiadiazines; Cooperative Behavior; Diet Therapy; Diuretics; Humans; H | 1975 |
Extranasal treatment of epistaxis.
Topics: Age Factors; Antihypertensive Agents; Chlorothiazide; Droperidol; Drug Combinations; Epistaxis; Fent | 1975 |
Hypothalamic monoamine metabolism in mice: evaluation of drug challenges and neurotoxic insult.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Animals, Newborn; Dopamine; Female; G | 1986 |
The treatment of mild hypertension in the elderly, a prospective study using multiple regression analysis.
Topics: Aged; Benzothiadiazines; Blood Pressure; Cholesterol; Diuretics; Female; Humans; Hydralazine; Hypert | 1985 |
Letter: Rauwolfia derivatives and breast cancer.
Topics: Antihypertensive Agents; Breast Neoplasms; Female; Finland; Humans; Hypertension; Male; Middle Aged; | 1974 |
[Initial results of the activity of the Angiocardiological Center in Kolomna].
Topics: Adolescent; Adult; Coronary Disease; Diabetes Complications; Female; Heparin; Humans; Hydrochlorothi | 1971 |
Transport and storage of 5-hydroxytryptamine in pancreatic -cells.
Topics: Animals; Biological Transport; Carbon Isotopes; Chromatography, Gel; Diazoxide; Glucose; Glyburide; | 1972 |
[Present status in pathogenesis, diagnosis and therapy of arterial hypertension].
Topics: Arteriosclerosis; Guanethidine; Hemodynamics; Humans; Hypertension; Obesity; Reserpine | 1972 |
Reproductive function in the genetically obese "fatty" rat.
Topics: Animals; Castration; Decidua; Estrus; Feedback; Female; Follicle Stimulating Hormone; Hypothalamo-Hy | 1973 |
The significance of 5-hydroxytryptamine for insulin secretion in the mouse.
Topics: 5-Hydroxytryptophan; Animals; Bromine; Drug Antagonism; Glucose; Hyperglycemia; In Vitro Techniques; | 1971 |