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reserpine and Obesity

reserpine has been researched along with Obesity in 28 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"In a controlled study (the control group receiving pyribenzamine) it was observed that reserpine, in the dosage used, had no effect on weight loss in patients receiving d-amphetamine sulphate (Dexedrine(R)) and methyl cellulose (Cellothyl(R)) while on 1,000-calorie diets as compared with the control group."7.64Reserpine in weight reduction. The effect in obese patients on 1,000-calorie diets: a controlled study. ( SMITH, MC, 1959)
"Obesity is associated with low-grade chronic inflammation and oxidative stress, affecting the brain's reward system by decreasing dopaminergic neurotransmission."5.72Effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced Parkinson's disease. ( Andrade, VM; Bitencourt, RM; Cavalheiro, EKFF; Cucker, L; da Silva, LE; Dal-Pizzol, F; Damiani, AP; Joaquim, L; Machado, RS; Magenis, ML; Michels, M; Oliveira, MP; Petronilho, F; Rezin, GT; Ribeiro, CB; Silva, MG; Tuon, T; Vilela, TC, 2022)
"Reserpine use was examined for yearly use by each year preceding the diagnosis of breast cancer, by cumulative yearly use, and by other defined time periods."5.25Matched-pairs study of reserpine use and breast cancer. ( Fischer, S; Laska, EM; Meisner, M; Siegel, C; Wanderling, J, 1975)
"Effect of reserpine on body weight (BW), feed intake (FI), brain and plasma catecholamine and indoleamine concentrations in high- (HWS) and low- (LWS) weight selected lines of chickens was investigated."3.73Differential autonomic nervous system response in obese and anorexic chickens (Gallus gallus). ( Denbow, DM; Kuo, AY; Lee, JC; Magnin, G; Siegel, PB, 2006)
"We compared the effects of long-term treatment with the angiotensin-converting enzyme inhibitor perindopril and triple therapy (hydrochlorothiazide, reserpine, and hydralazine) on the metabolic and renal features in the SHR/N-corpulent (cp) rat, a genetic model of non-insulin-dependent diabetes mellitus and hypertension."3.69Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulent rat. ( Abraham, AA; Michaelis, OE; Scalbert, E; Striffler, JS; Thibault, N; Velasquez, MT, 1997)
"In a controlled study (the control group receiving pyribenzamine) it was observed that reserpine, in the dosage used, had no effect on weight loss in patients receiving d-amphetamine sulphate (Dexedrine(R)) and methyl cellulose (Cellothyl(R)) while on 1,000-calorie diets as compared with the control group."3.64Reserpine in weight reduction. The effect in obese patients on 1,000-calorie diets: a controlled study. ( SMITH, MC, 1959)
"Obesity is associated with low-grade chronic inflammation and oxidative stress, affecting the brain's reward system by decreasing dopaminergic neurotransmission."1.72Effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced Parkinson's disease. ( Andrade, VM; Bitencourt, RM; Cavalheiro, EKFF; Cucker, L; da Silva, LE; Dal-Pizzol, F; Damiani, AP; Joaquim, L; Machado, RS; Magenis, ML; Michels, M; Oliveira, MP; Petronilho, F; Rezin, GT; Ribeiro, CB; Silva, MG; Tuon, T; Vilela, TC, 2022)
"In order to examine the effect of treatment of mild hypertension of the aged, a 4 year prospective trial was performed in 41 placebo and 38 drug-treated patients with an average age of 76."1.27The treatment of mild hypertension in the elderly, a prospective study using multiple regression analysis. ( Kuramoto, K; Matsushita, S, 1985)
"Reserpine use was examined for yearly use by each year preceding the diagnosis of breast cancer, by cumulative yearly use, and by other defined time periods."1.25Matched-pairs study of reserpine use and breast cancer. ( Fischer, S; Laska, EM; Meisner, M; Siegel, C; Wanderling, J, 1975)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199025 (89.29)18.7374
1990's1 (3.57)18.2507
2000's1 (3.57)29.6817
2010's0 (0.00)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Cavalheiro, EKFF1
da Silva, LE1
Oliveira, MP1
Silva, MG1
Damiani, AP1
Ribeiro, CB1
Magenis, ML1
Cucker, L1
Michels, M1
Joaquim, L1
Machado, RS1
Vilela, TC1
Bitencourt, RM1
Andrade, VM1
Dal-Pizzol, F1
Petronilho, F1
Tuon, T1
Rezin, GT1
KINARD, S2
MILLS, LC2
MOYER, JH2
TERRELL, J2
KROGSGAARD, AR1
SMITH, MC1
ALBEAUX-FERNET, M1
SCHWARTZ, W1
TURNER, RW1
MILLIGAN, J1
HUGHES, RG1
Kuo, AY1
Lee, JC1
Magnin, G1
Siegel, PB1
Denbow, DM1
Hays, SE1
Goodwin, FK1
Paul, SM1
Milovidova, SS1
Liakhova, TM1
Velasquez, MT1
Striffler, JS1
Abraham, AA1
Michaelis, OE1
Scalbert, E1
Thibault, N1
Laska, EM1
Siegel, C1
Meisner, M1
Fischer, S1
Wanderling, J1
Giovannini, C1
Sellini, M1
Marchesi, L1
Fierro, A1
Massimiani, F1
Levin, ML1
Thomas, DB1
Hickler, RB1
Rahman, JC1
Drumheller, GH1
Dawson, R1
Callahan, MF1
Annau, Z1
Kuramoto, K1
Matsushita, S1
Waal-Manning, HJ1
Simpson, FO1
Ryvkin, IA1
Korsunskiĭ, AA1
Pribylova, LP1
Lobanova, LS1
Raĭskaia, AM1
Mise, J1
Hellman, B1
Lernmark, A2
Sehlin, J1
Täljedal, IB1
Negoita, CJ1
Saiduddin, S1
Bray, GA1
York, DA1
Swerdloff, RS1

Reviews

1 review available for reserpine and Obesity

ArticleYear
Pulmonary hypertension.
    Japanese circulation journal, 1974, Volume: 38, Issue:12

    Topics: Adult; Aging; Cardiac Output; Chronic Disease; Electrocardiography; Humans; Hypertension, Pulmonary;

1974

Trials

1 trial available for reserpine and Obesity

ArticleYear
Fenfluramine in obese patients on various antihypertensive drugs. Double-blind controlled trial.
    Lancet (London, England), 1969, Dec-27, Volume: 2, Issue:7635

    Topics: Antihypertensive Agents; Appetite Depressants; Blood Glucose; Blood Pressure; Body Weight; Cholester

1969

Other Studies

26 other studies available for reserpine and Obesity

ArticleYear
Effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced Parkinson's disease.
    Behavioural brain research, 2022, 09-26, Volume: 434

    Topics: Animals; Disease Models, Animal; Inflammation; Obesity; Oxidative Stress; Parkinson Disease; Reserpi

2022
Use of d-amphetamine to curb the increased appetite and over-eating induced by reserpine therapy.
    Journal of the American Geriatrics Society, 1956, Volume: 4, Issue:11

    Topics: Amphetamine; Amphetamines; Appetite; Autonomic Nervous System Diseases; Dextroamphetamine; Feeding a

1956
Use of d-amphetamine to curb the increased appetite and over-eating induced by reserpine therapy.
    Journal of the American Geriatrics Society, 1956, Volume: 4, Issue:11

    Topics: Amphetamine; Amphetamines; Appetite; Autonomic Nervous System Diseases; Dextroamphetamine; Feeding a

1956
Use of d-amphetamine to curb the increased appetite and over-eating induced by reserpine therapy.
    Journal of the American Geriatrics Society, 1956, Volume: 4, Issue:11

    Topics: Amphetamine; Amphetamines; Appetite; Autonomic Nervous System Diseases; Dextroamphetamine; Feeding a

1956
Use of d-amphetamine to curb the increased appetite and over-eating induced by reserpine therapy.
    Journal of the American Geriatrics Society, 1956, Volume: 4, Issue:11

    Topics: Amphetamine; Amphetamines; Appetite; Autonomic Nervous System Diseases; Dextroamphetamine; Feeding a

1956
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression.
    Acta medica Scandinavica, 1958, Dec-20, Volume: 162, Issue:6

    Topics: Depression; Depressive Disorder; Essential Hypertension; Humans; Hypertension; Obesity; Reserpine; W

1958
Reserpine in weight reduction. The effect in obese patients on 1,000-calorie diets: a controlled study.
    California medicine, 1959, Volume: 91

    Topics: Dextroamphetamine; Diet, Reducing; Humans; Obesity; Reserpine; Weight Loss

1959
[THE ROUTE OF AN OBESE WOMAN HAPPILY CHANGED THROUGH A WELL-FOLLOWED ITINERARY].
    Concours medical, 1963, Sep-21, Volume: 85

    Topics: Diet, Reducing; Female; Happiness; Humans; Mineral Waters; Obesity; Reserpine

1963
MEBUTAMATE AND HYDROCHLOROTHIAZIDE IN HYPERTENSION.
    Journal of the American Geriatrics Society, 1964, Volume: 12

    Topics: Antihypertensive Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure Determination; Carbamates;

1964
HYPERTENSION AND ITS COMPLICATIONS. 2.
    Nursing times, 1964, Jun-26, Volume: 60

    Topics: Amobarbital; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Cold Temperature

1964
Obesity--an approach to the problem with methamphetamine-reserpine combined therapy.
    Western medicine; the medical journal of the west, 1960, Volume: 1

    Topics: Amphetamine; Amphetamines; Humans; Methamphetamine; Obesity; Psychotherapy, Multiple; Reserpine

1960
Differential autonomic nervous system response in obese and anorexic chickens (Gallus gallus).
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2006, Volume: 144, Issue:3

    Topics: Animal Feed; Animals; Anorexia; Autonomic Nervous System; Body Weight; Brain; Catecholamines; Chicke

2006
Cholecystokinin receptors in brain: effects of obesity, drug treatment, and lesions.
    Peptides, 1981, Volume: 2 Suppl 1

    Topics: Amphetamine; Animals; Brain; Caudate Nucleus; Fasting; Humans; Huntington Disease; In Vitro Techniqu

1981
[Effectiveness of different methods of treatment for obesity and arterial hypertension].
    Sovetskaia meditsina, 1983, Issue:11

    Topics: Combined Modality Therapy; Female; Hemodynamics; Humans; Hypertension; Middle Aged; Obesity; Reserpi

1983
Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulent rat.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Diabetes Mellitus, Type

1997
Matched-pairs study of reserpine use and breast cancer.
    Lancet (London, England), 1975, Aug-16, Volume: 2, Issue:7929

    Topics: Aged; Breast Neoplasms; Diagnosis, Computer-Assisted; Family Characteristics; Female; Hospital Recor

1975
[Behavior of plasma cortisol during testing with insulin and with LVP in obese subjects compared to normal subjects after resperine administration].
    Bollettino della Societa italiana di biologia sperimentale, 1979, Dec-30, Volume: 55, Issue:24

    Topics: Humans; Hydrocortisone; Insulin; Lypressin; Obesity; Reserpine

1979
The epidemiology of breast cancer.
    Progress in clinical and biological research, 1977, Volume: 12

    Topics: Adult; Age Factors; Aged; Breast Diseases; Breast Neoplasms; Dietary Fats; Estrogens; Ethnicity; Fem

1977
The office management of hypertension.
    Angiology, 1975, Volume: 26, Issue:1 Pt. 1

    Topics: Adult; Age Factors; Ambulatory Care; Antihypertensive Agents; Benzothiadiazines; Black or African Am

1975
Hypertension.
    Occupational health nursing, 1975, Volume: 23, Issue:1

    Topics: Antihypertensive Agents; Benzothiadiazines; Cooperative Behavior; Diet Therapy; Diuretics; Humans; H

1975
Extranasal treatment of epistaxis.
    Rhinology, 1975, Volume: 13, Issue:2

    Topics: Age Factors; Antihypertensive Agents; Chlorothiazide; Droperidol; Drug Combinations; Epistaxis; Fent

1975
Hypothalamic monoamine metabolism in mice: evaluation of drug challenges and neurotoxic insult.
    Pharmacology, 1986, Volume: 32, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Animals, Newborn; Dopamine; Female; G

1986
The treatment of mild hypertension in the elderly, a prospective study using multiple regression analysis.
    Japanese circulation journal, 1985, Volume: 49, Issue:11

    Topics: Aged; Benzothiadiazines; Blood Pressure; Cholesterol; Diuretics; Female; Humans; Hydralazine; Hypert

1985
Letter: Rauwolfia derivatives and breast cancer.
    Lancet (London, England), 1974, Nov-30, Volume: 2, Issue:7892

    Topics: Antihypertensive Agents; Breast Neoplasms; Female; Finland; Humans; Hypertension; Male; Middle Aged;

1974
[Initial results of the activity of the Angiocardiological Center in Kolomna].
    Kardiologiia, 1971, Volume: 11, Issue:10

    Topics: Adolescent; Adult; Coronary Disease; Diabetes Complications; Female; Heparin; Humans; Hydrochlorothi

1971
Transport and storage of 5-hydroxytryptamine in pancreatic -cells.
    Biochemical pharmacology, 1972, Mar-01, Volume: 21, Issue:5

    Topics: Animals; Biological Transport; Carbon Isotopes; Chromatography, Gel; Diazoxide; Glucose; Glyburide;

1972
[Present status in pathogenesis, diagnosis and therapy of arterial hypertension].
    Giornale di clinica medica, 1972, Volume: 53, Issue:10

    Topics: Arteriosclerosis; Guanethidine; Hemodynamics; Humans; Hypertension; Obesity; Reserpine

1972
Reproductive function in the genetically obese "fatty" rat.
    Endocrinology, 1973, Volume: 93, Issue:6

    Topics: Animals; Castration; Decidua; Estrus; Feedback; Female; Follicle Stimulating Hormone; Hypothalamo-Hy

1973
The significance of 5-hydroxytryptamine for insulin secretion in the mouse.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1971, Volume: 3, Issue:5

    Topics: 5-Hydroxytryptophan; Animals; Bromine; Drug Antagonism; Glucose; Hyperglycemia; In Vitro Techniques;

1971