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reserpine and Neuroendocrine Tumors

reserpine has been researched along with Neuroendocrine Tumors in 2 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Neuroendocrine Tumors: Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.

Research Excerpts

ExcerptRelevanceReference
" In the VMAT-expressing NE tumour cell lines GOT1 and BON and in VMAT-expressing primary NE tumour cell cultures (carcinoids, n=4 and pheochromocytomas, n=4), reserpine significantly reduced the uptake of (123)I-MIBG."3.72Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters. ( Ahlman, H; Bernhardt, P; Forssell-Aronsson, E; Johanson, V; Kölby, L; Levin-Jakobsen, AM; Nilsson, O; Wängberg, B, 2003)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kölby, L2
Bernhardt, P2
Levin-Jakobsen, AM1
Johanson, V1
Wängberg, B1
Ahlman, H2
Forssell-Aronsson, E2
Nilsson, O2
Jakobsen, AM1

Other Studies

2 other studies available for reserpine and Neuroendocrine Tumors

ArticleYear
Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters.
    British journal of cancer, 2003, Oct-06, Volume: 89, Issue:7

    Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adrenergic Uptake Inhibitors; Animals; Antineoplasti

2003
Importance of vesicle proteins in the diagnosis and treatment of neuroendocrine tumors.
    Annals of the New York Academy of Sciences, 2004, Volume: 1014

    Topics: 3-Iodobenzylguanidine; Adenocarcinoma; Adrenal Gland Neoplasms; Adrenergic Uptake Inhibitors; Biopsy

2004