reserpine has been researched along with Neuroblastoma in 14 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with reserpine, which increases conversion of peptide B to the heptapeptide in bovine chromaffin cells in culture does not stimulate the accumulation of Met-enkephalyl-Arg6-Phe7 in the human neuroblastoma cells." | 5.27 | Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine. ( Adams, M; Boarder, MR; Marriott, D, 1986) |
| " Chronic administration of 6-hydroxydopamine (100 micrograms/g for 8 days) had no effect on the tissue contents of dopamine, noradrenaline or dopamine B-hydroxylase." | 1.27 | Release of dopamine, noradrenaline and dopamine B-hydroxylase from mouse neuroblastoma. ( De Schaepdryver, AF; De Smet, FH; Fraeyman, NH; Moerman, EJ; Van de Velde, EJ, 1984) |
| "Treatment with reserpine, which increases conversion of peptide B to the heptapeptide in bovine chromaffin cells in culture does not stimulate the accumulation of Met-enkephalyl-Arg6-Phe7 in the human neuroblastoma cells." | 1.27 | Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine. ( Adams, M; Boarder, MR; Marriott, D, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nilsson, O | 1 |
| Jakobsen, AM | 1 |
| Kölby, L | 1 |
| Bernhardt, P | 1 |
| Forssell-Aronsson, E | 1 |
| Ahlman, H | 1 |
| Fraeyman, NH | 1 |
| De Smet, FH | 1 |
| Van de Velde, EJ | 1 |
| Moerman, EJ | 1 |
| De Schaepdryver, AF | 1 |
| Tinti, C | 1 |
| Conti, B | 1 |
| Cubells, JF | 1 |
| Kim, KS | 1 |
| Baker, H | 1 |
| Joh, TH | 1 |
| Cornelissen, J | 1 |
| Tytgat, GA | 1 |
| van den Brug, M | 1 |
| van Kuilenburg, AB | 1 |
| Voûte, PA | 1 |
| van Gennip, AH | 1 |
| Greene, LA | 1 |
| Rein, G | 1 |
| Poffenbarger, M | 1 |
| Fuller, GM | 1 |
| Rotman, A | 1 |
| Daly, JW | 1 |
| Creveling, CR | 1 |
| Breakefield, XO | 2 |
| Horn, PT | 1 |
| Mirkin, BL | 1 |
| Boarder, MR | 1 |
| Marriott, D | 1 |
| Adams, M | 1 |
| Smets, LA | 1 |
| Loesberg, C | 1 |
| Janssen, M | 1 |
| Metwally, EA | 1 |
| Huiskamp, R | 1 |
| Bräutigam, M | 1 |
| Laschinski, G | 1 |
| Kittner, B | 1 |
| Herken, H | 1 |
| Hermetet, JC | 1 |
| Ciesielski-Treska, J | 1 |
| Mandel, P | 1 |
| Shimbo, S | 1 |
14 other studies available for reserpine and Neuroblastoma
| Article | Year |
|---|---|
Importance of vesicle proteins in the diagnosis and treatment of neuroendocrine tumors.
Topics: 3-Iodobenzylguanidine; Adenocarcinoma; Adrenal Gland Neoplasms; Adrenergic Uptake Inhibitors; Biopsy | 2004 |
Release of dopamine, noradrenaline and dopamine B-hydroxylase from mouse neuroblastoma.
Topics: Animals; Dopamine; Dopamine beta-Hydroxylase; Hydroxydopamines; Male; Mice; Mice, Inbred A; Neurobla | 1984 |
Inducible cAMP early repressor can modulate tyrosine hydroxylase gene expression after stimulation of cAMP synthesis.
Topics: Activating Transcription Factors; Adrenal Glands; Animals; Blood Proteins; Brain; Chloramphenicol O- | 1996 |
Menadione inhibits MIBG uptake in two neuroendocrine cell lines.
Topics: 3-Iodobenzylguanidine; Adrenergic Uptake Inhibitors; Animals; Antineoplastic Agents; Cytoplasmic Gra | 1997 |
Dopaminergic properties of a somatic cell hybrid line of mouse neuroblastoma X sympathetic ganglion cells.
Topics: Animals; Bucladesine; Cell Line; Dopa Decarboxylase; Dopamine; Enzyme Induction; Ganglia, Autonomic; | 1977 |
Effects of psychotropic drugs on neurotubule assembly.
Topics: Binding Sites; Brain; Cells, Cultured; Chlorpromazine; Colchicine; Dextroamphetamine; Dose-Response | 1977 |
Uptake and binding of dopamine and 6-hydroxydopamine in murine neuroblastoma and fibroblast cells.
Topics: Animals; Cell Line; Dopamine; Electrophoresis, Polyacrylamide Gel; Hydroxydopamines; L Cells; Mice; | 1976 |
Reserpine sensitivity of catecholamine metabolism in murine neuroblastoma clone N1E-115.
Topics: Biological Transport, Active; Cell Line; Dopamine; Kinetics; Neuroblastoma; Norepinephrine; Reserpin | 1975 |
Modulation of in situ murine neuroblastoma tumor growth by the adrenergic nervous system: differential response of clonal cell lines to chemical sympathectomy.
Topics: Animals; Carcinogenicity Tests; Cell Division; Dopamine; Female; Hydroxydopamines; Mice; Mice, Inbre | 1990 |
Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Bucladesine; Cell Line; Cyclic AMP; Enkephalin, Methionine | 1986 |
Active uptake and extravesicular storage of m-iodobenzylguanidine in human neuroblastoma SK-N-SH cells.
Topics: 3-Iodobenzylguanidine; Humans; Imipramine; Iodine Radioisotopes; Iodobenzenes; Neuroblastoma; Norepi | 1989 |
Effect of apomorphine, alpha-methylparatyrosine, haloperidol and reserpine on DOPA production in clonal cell lines (PC-12 and N1E-115).
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Apomorphine; Cell Line; Dihydroxyphenylalani | 1985 |
Cytochemical demonstration of catecholamines and acetylcholinesterase activity in neuroblastoma cells in culture.
Topics: Acetylcholinesterase; Animals; Catecholamines; Cell Line; Cells, Cultured; Fluorescence; Formaldehyd | 1972 |
[Clinical studies on urinary metanephrine and normetanephrine in various endocrine diseases. 2. Clinical studies on urinary metanephrine and normetanephrine in patients with pheochromyocytoma and a patient with neuroblastoma].
Topics: Adult; Bretylium Compounds; Catecholamines; Child, Preschool; Female; Histamine; Humans; Male; Methy | 1968 |