reserpine has been researched along with Nerve Degeneration in 27 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The stronger in vivo effect of (+)-catechin on L-DOPA methylation compared to the other dietary compounds is due to its better bioavailability in vivo." | 1.39 | Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. ( Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT, 2013) |
| " It is known that dopamine (DA) enhances this toxic effect." | 1.35 | Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production. ( Cano, J; de Pablos, RM; Herrera, AJ; Machado, A; Navarro, A; Santiago, M; Tomás-Camardiel, M; Villarán, RF, 2008) |
| "Reserpine treatment alone did not change the levels of DA or 2,3-DHBA, while the combined treatment with both MPP(+) and reserpine clearly decreased 2,3-DHBA, as well as DA levels, compared to those in the group treated with MPP(+) alone." | 1.31 | Release of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (MPP(+)) into the striatum is associated with hydroxyl free radical generation. ( Kinemuchi, H; Obata, T; Oreland, L; Yamanaka, Y, 2001) |
| "When desipramine (5mM) was added in order to block neuronal uptake the corresponding figures were 4." | 1.27 | Reduced uptake of noradrenaline into storage vesicles from the pregnant uterus. ( Dahlin, I; Fried, G; Hammarström, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (81.48) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, KS | 1 |
| Yamabe, N | 1 |
| Wen, Y | 1 |
| Fukui, M | 1 |
| Zhu, BT | 1 |
| Villarán, RF | 1 |
| Tomás-Camardiel, M | 1 |
| de Pablos, RM | 1 |
| Santiago, M | 1 |
| Herrera, AJ | 1 |
| Navarro, A | 1 |
| Machado, A | 1 |
| Cano, J | 1 |
| Mennini, T | 2 |
| Pataccini, R | 1 |
| Crunelli, V | 1 |
| Caccia, S | 1 |
| Ballabio, M | 1 |
| Samanin, R | 1 |
| Garattini, S | 1 |
| Gobbi, M | 1 |
| Regondi, MC | 1 |
| Pompeiano, M | 1 |
| Palacios, JM | 1 |
| Obata, T | 1 |
| Yamanaka, Y | 1 |
| Kinemuchi, H | 1 |
| Oreland, L | 1 |
| Onozuka, M | 1 |
| Kubo, K | 1 |
| Deura, S | 1 |
| Karasawa, N | 1 |
| Nagatsu, I | 1 |
| Fried, G | 1 |
| Hammarström, M | 1 |
| Dahlin, I | 1 |
| Häggendal, J | 2 |
| Dahlström, A | 2 |
| Steg, G | 1 |
| Andén, NE | 1 |
| Ungerstedt, U | 2 |
| Bareggi, S | 1 |
| Treister, G | 1 |
| Bárány, EH | 1 |
| Stefano, FJ | 1 |
| Perec, CJ | 1 |
| Tumilasci, OR | 1 |
| Sachs, C | 5 |
| Taxi, J | 1 |
| Caramia, F | 1 |
| Ubaldo Angeletti, P | 1 |
| Levi-Montalcini, R | 1 |
| Carratelli, L | 1 |
| Jonsson, G | 2 |
| Malmfors, T | 4 |
| Bennett, T | 1 |
| Cobb, JL | 1 |
| Corrodi, H | 1 |
| Masuoka, DT | 1 |
| Clark, WG | 1 |
| Terayama, Y | 1 |
| Yamamoto, K | 1 |
| Sakamoto, T | 1 |
| Nishida, S | 1 |
| Sears, M | 1 |
| Langer, SZ | 1 |
2 reviews available for reserpine and Nerve Degeneration
| Article | Year |
|---|---|
Pathological aspects on Parkinson's syndrome.
Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Central Nervous System; Chlorpromazine; Corpus Stria | 1972 |
Morphological and cytochemical studies on the synapses in the autonomic nervous system.
Topics: 5-Hydroxytryptophan; Animals; Autonomic Nervous System; Autoradiography; Catecholamines; Ganglia, Au | 1969 |
25 other studies available for reserpine and Nerve Degeneration
| Article | Year |
|---|---|
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catech | 2013 |
Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production.
Topics: alpha-Methyltyrosine; Animals; Apoptosis; Astrocytes; Cell Respiration; Corpus Striatum; Dopamine; D | 2008 |
Localization of fenfluramine and reserpine in brain regions of rats with extensive degeneration of 5-hydroxytryptaminergic neurons.
Topics: Animals; Brain; Corpus Striatum; Female; Fenfluramine; Nerve Degeneration; Raphe Nuclei; Rats; Recep | 1980 |
Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain; Ci | 1994 |
Release of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (MPP(+)) into the striatum is associated with hydroxyl free radical generation.
Topics: 1-Methyl-4-phenylpyridinium; Adrenergic Uptake Inhibitors; Animals; Antifungal Agents; Cell Membrane | 2001 |
Modification of noradrenergic innervation in the cerebellum of mutant rats with Purkinje cell degeneration (jaundiced Gunn rats).
Topics: Animals; Cerebellum; Chromatography, High Pressure Liquid; Dopamine; Epinephrine; Immunohistochemist | 1990 |
Reduced uptake of noradrenaline into storage vesicles from the pregnant uterus.
Topics: Adenosine Triphosphate; Animals; Desipramine; Female; Guinea Pigs; Magnesium; Nerve Degeneration; No | 1985 |
The importance of axoplasmic transport of amine granules for the functions of adrenergic neurons.
Topics: Animals; Axonal Transport; Axons; Cytoplasmic Granules; Cytoplasmic Streaming; Muscles; Nerve Degene | 1971 |
Effect of acute axotomy (spinal cord transection) on the turnover of 5-hydroxytryptamine.
Topics: Acetamides; Amphetamine; Animals; Catechols; Fenclonine; Hallucinogens; Hydroxyindoleacetic Acid; Ly | 1974 |
Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour.
Topics: Amphetamine; Animals; Apomorphine; Brain; Butyrophenones; Dopamine; Electrocoagulation; Haloperidol; | 1971 |
Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.
Topics: Animals; Apomorphine; Brain Chemistry; Brain Injuries; Carboxy-Lyases; Dihydroxyphenylalanine; Dopam | 1971 |
Intra-axonal transport and degeneration of adrenergic nerve terminals after axotomy with long and short nerve stump.
Topics: Animals; Axons; Depression, Chemical; Male; Muscle, Smooth; Nerve Degeneration; Nerve Endings; Norep | 1974 |
Degeneration mydriasis and hyperemia of the iris after superior cervical ganglionectomy in the rabbit. Evidence for release of more than norepinephrine during degeneration of adrenergic terminals.
Topics: Accommodation, Ocular; Adrenergic alpha-Antagonists; Animals; Atropine; Bretylium Compounds; Chlorpr | 1970 |
Changes in neuronal uptake and metabolism of, and sensitivity to, norepinephrine during the degeneration secretion in the rat submaxillary gland.
Topics: Animals; Autonomic Fibers, Postganglionic; Cocaine; Female; In Vitro Techniques; Nerve Degeneration; | 1974 |
Failure of 6-hydroxynoradrenaline to produce degeneration of catecholamine neurons.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Dopamine beta-Hydroxylase; Heart; Heart Atria; | 1972 |
Mitochondrial lesions of developing sympathetic neurons induced by bretylium tosylate.
Topics: Animals; Animals, Newborn; Bretylium Compounds; Dopamine; Ganglia, Autonomic; Guanethidine; Microsco | 1972 |
Effects of drugs on the 6-hydroxydopamine induced degeneration of adrenergic nerves.
Topics: Amphetamine; Animals; Bretylium Compounds; Dopamine; Drug Interactions; Heart Atria; Histocytochemis | 1972 |
Fluorescence histochemical observations on Auerbach's plexus and the problem of the inhibitory innervation of the gut.
Topics: Animals; Chickens; Digestive System; Epinephrine; Fluorescence; Histocytochemistry; Myenteric Plexus | 1971 |
Effect of 6-hydroxydopamine on rat heart noradrenaline.
Topics: Animals; Desipramine; Dopamine; Drug Interactions; Male; Monoamine Oxidase Inhibitors; Myocardium; N | 1971 |
Uptake and accumulation of 3 H-6-hydroxydopamine in adrenergic nerves.
Topics: Animals; Dopamine; Histocytochemistry; Male; Mice; Mice, Inbred Strains; Microscopy, Fluorescence; N | 1971 |
Degeneration of adrenergic nerves produced by 6-hydroxydopamine.
Topics: Animals; Axons; Bretylium Compounds; Depression, Chemical; Dopamine; Drug Synergism; Fluorescence; H | 1968 |
Electron microscopic observations on the postaganglionic sympathetic fibers in the guinea pig cochlea.
Topics: Animals; Cochlea; Guinea Pigs; Male; Microscopy, Electron; Nerve Degeneration; Peripheral Nerves; Re | 1968 |
Fine structural innervation of the dilator muscle of the iris of the albino guinea pig studied with permanganate fixation.
Topics: Animals; Axons; Cytoplasmic Granules; Ganglia, Autonomic; Guinea Pigs; Iris; Microscopy, Electron; M | 1969 |
Direct studies on the disappearance of the transmitter and changes in the uptake-storage mechanisms of degenerating adrenergic nerves.
Topics: Animals; Axons; Bretylium Compounds; Iris; Microscopy, Fluorescence; Nerve Degeneration; Neurochemis | 1965 |
The degeneration contraction of the nictitating membrane in the unanesthetized cat.
Topics: Animals; Cats; Denervation; Dibenzylchlorethamine; In Vitro Techniques; Muscle Contraction; Muscles; | 1966 |