reserpine has been researched along with Neoplasms in 24 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Association between the use of reserpine and breast cancer in women, between atenolol and some types of cancer in elderly men also can not be ruled out." | 4.81 | [Antihypertensive drugs and malignant neoplasia]. ( Kiktev, VG; Preobrazhenskiĭ, DV; Sidorenko, BA; Stetsenko, TM, 2002) |
| " Early retrospective studies implicated reserpine in breast cancer, but data from prospective studies and meta-analysis of several case-controlled studies showed only a weak association between reserpine and breast cancer which, although statistically significant, is of little clinical concern." | 4.81 | Carcinogenicity of antihypertensive therapy. ( Goldbourt, U; Grossman, E; Messerli, FH, 2002) |
| " Early retrospective studies implicated reserpine in breast cancer, but the drug was later absolved by prospective analyses." | 4.80 | Carcinogenicity of cardiovascular drugs. ( Goldbourt, U; Grossman, E; Messerli, FH, 1999) |
| "The association between diuretics and renal cell carcinoma was analysed in 4389 cases and 6566 controls, yielding a pooled OR of 1." | 2.41 | Antihypertensive therapy and the risk of malignancies. ( Goldbourt, U; Grossman, E; Messerli, FH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (54.17) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Joshi, P | 1 |
| Vishwakarma, RA | 1 |
| Bharate, SB | 1 |
| Brown, JS | 1 |
| Jørgensen, JT | 1 |
| Hersom, M | 1 |
| Benjamin, D | 1 |
| Robay, D | 1 |
| Hindupur, SK | 1 |
| Pohlmann, J | 1 |
| Colombi, M | 1 |
| El-Shemerly, MY | 1 |
| Maira, SM | 1 |
| Moroni, C | 1 |
| Lane, HA | 1 |
| Hall, MN | 1 |
| Jin, GB | 1 |
| Hong, T | 1 |
| Inoue, S | 1 |
| Urano, T | 1 |
| Cho, S | 1 |
| Otsu, K | 1 |
| Kitahara, M | 1 |
| Ouchi, Y | 1 |
| Cyong, JC | 1 |
| Preobrazhenskiĭ, DV | 1 |
| Sidorenko, BA | 1 |
| Stetsenko, TM | 1 |
| Kiktev, VG | 1 |
| LANGEMANN, H | 1 |
| GOERRE, J | 1 |
| WEST, WL | 1 |
| BAIRD, GM | 1 |
| STEWARD, JD | 1 |
| PRADHAN, SN | 1 |
| WILLHEIM, R | 1 |
| O'MALLEY, BB | 1 |
| FLUSS, P | 1 |
| DICKSON, J | 1 |
| AUBER, M | 1 |
| SHIONOYA, S | 1 |
| CARLINI, GR | 1 |
| FISCHER, GA | 1 |
| GIARMAN, NJ | 3 |
| LACASSAGNE, A | 1 |
| VANORDEN, LS | 1 |
| VUGMAN, I | 2 |
| Van Orden, LS | 1 |
| Bensch, KG | 1 |
| Grossman, E | 3 |
| Messerli, FH | 3 |
| Goldbourt, U | 3 |
| Marquardt, H | 1 |
| Faigle, JW | 1 |
| Dörhöfer, G | 1 |
| Lapin, V | 1 |
| Schmähl, D | 1 |
| Muradian, RE | 1 |
7 reviews available for reserpine and Neoplasms
| Article | Year |
|---|---|
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member | 2017 |
Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer.
Topics: Antipsychotic Agents; Chlorpromazine; Humans; Methylene Blue; Neoplasms; Phenothiazines; Reserpine; | 2022 |
Clinical and Regulatory Aspects of Companion Diagnostic Development in Oncology.
Topics: Antineoplastic Agents; Biological Assay; Drug Approval; Drug Development; Humans; Medical Oncology; | 2018 |
[Antihypertensive drugs and malignant neoplasia].
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Age Factors; Aged; Angiotensin-Converting | 2002 |
Carcinogenicity of cardiovascular drugs.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Brea | 1999 |
Antihypertensive therapy and the risk of malignancies.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aten | 2001 |
Carcinogenicity of antihypertensive therapy.
Topics: Animals; Antihypertensive Agents; Breast Neoplasms; Carcinogens; Humans; Hypertension; Longitudinal | 2002 |
17 other studies available for reserpine and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.
Topics: Acids; Animals; Cell Line, Tumor; Energy Metabolism; Humans; Intracellular Space; Lactic Acid; Male; | 2018 |
Reserpine.
Topics: Adrenergic Uptake Inhibitors; Animals; Antihypertensive Agents; Humans; Neoplasms; Reserpine | 2011 |
Augmentation of immune cell activity against tumor cells by Rauwolfia radix.
Topics: Animals; Blotting, Western; Cell Survival; Concanavalin A; Cytotoxicity, Immunologic; Female; Gene E | 2002 |
[Suppression of hydroxyindole-acetic acid excretion in urine after reserpine administration in humans; with special consideration to carcinoid syndrome].
Topics: Acetates; Carcinoid Tumor; Gastrointestinal Tract; Hydroxyindoleacetic Acid; Indoleacetic Acids; Mal | 1957 |
Some studies on the anti-tumor effect of reserpine in mice.
Topics: Animals; Antineoplastic Agents; Mice; Neoplasms; Neoplasms, Experimental; Reserpine | 1961 |
FURTHER STUDIES CONCERNING CARCINOLYSIS.
Topics: Animals; Antineoplastic Agents; Blood; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Mice; Neoplasms | 1963 |
ELECTRON MICROSCOPIC STUDY ON THE CATECHOLAMINE METABOLISM IN THE HUMAN ADRENAL MEDULLA.
Topics: Adrenal Medulla; Adrenalectomy; Arteriosclerosis Obliterans; Catecholamines; Disease; Electrons; Fem | 1963 |
DIFFERENCES IN CHARACTERISTICS OF RELEASE OF SEROTONIN FROM NEOPLASTIC MAST CELLS IN CULTURE BY RESERPINE AND CHLORPROMAZINE.
Topics: Chlorpromazine; Mast Cells; Metabolism; Monoamine Oxidase Inhibitors; Neoplasms; Neoplasms, Experime | 1964 |
[RELATIONS BETWEEN THE TUMOR AND ORGANISM. THE ROLE OF THE HYPOTHALAMUS].
Topics: Chlorpromazine; Gold; Hypothalamus; Neoplasms; Neoplasms, Experimental; Neurophysiology; Pharmacolog | 1964 |
5-HYDROXYTRYPTAMINE IN SINGLE NEOPLASTIC MAST CELLS: A MICROSCOPIC SPECTROFLUOROMETRIC STUDY.
Topics: Animals; Breast Neoplasms; Catecholamines; Fluorescence; Fluorometry; Histamine; Humans; Mammary Neo | 1965 |
Biochemical, histochemical and electron-microscopic studies of 5-hydroxytryptamine in neoplastic mast cells.
Topics: Acid Phosphatase; Animals; Cell Membrane; Clone Cells; Culture Techniques; Cytoplasm; Cytoplasmic Gr | 1967 |
Letter: Reserpine and chemical carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Culture Techniques; Mice; Neoplasms; Reserpine | 1975 |
Letter: Reserpine and chemical carcinogenesis.
Topics: Aldehydes; Benzoates; Biotransformation; Carcinogens; Cinnamates; Humans; Methyl Ethers; Neoplasms; | 1975 |
Pineal influences on tumor.
Topics: Animals; Animals, Newborn; Carcinogens; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental | 1979 |
[Carcinogenic effect of reserpine?].
Topics: Breast Neoplasms; Female; Humans; Neoplasms; Reserpine | 1978 |
[Study of the potential carcinogenic activity of reserpine].
Topics: Animals; Carcinogens; Female; Male; Mice; Neoplasms; Rats; Reserpine; Species Specificity | 1986 |