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reserpine and Neoplasms

reserpine has been researched along with Neoplasms in 24 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" Association between the use of reserpine and breast cancer in women, between atenolol and some types of cancer in elderly men also can not be ruled out."4.81[Antihypertensive drugs and malignant neoplasia]. ( Kiktev, VG; Preobrazhenskiĭ, DV; Sidorenko, BA; Stetsenko, TM, 2002)
" Early retrospective studies implicated reserpine in breast cancer, but data from prospective studies and meta-analysis of several case-controlled studies showed only a weak association between reserpine and breast cancer which, although statistically significant, is of little clinical concern."4.81Carcinogenicity of antihypertensive therapy. ( Goldbourt, U; Grossman, E; Messerli, FH, 2002)
" Early retrospective studies implicated reserpine in breast cancer, but the drug was later absolved by prospective analyses."4.80Carcinogenicity of cardiovascular drugs. ( Goldbourt, U; Grossman, E; Messerli, FH, 1999)
"The association between diuretics and renal cell carcinoma was analysed in 4389 cases and 6566 controls, yielding a pooled OR of 1."2.41Antihypertensive therapy and the risk of malignancies. ( Goldbourt, U; Grossman, E; Messerli, FH, 2001)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199013 (54.17)18.7374
1990's1 (4.17)18.2507
2000's5 (20.83)29.6817
2010's4 (16.67)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Diamandis, P1
Wildenhain, J1
Clarke, ID1
Sacher, AG1
Graham, J1
Bellows, DS1
Ling, EK1
Ward, RJ1
Jamieson, LG1
Tyers, M1
Dirks, PB1
Joshi, P1
Vishwakarma, RA1
Bharate, SB1
Brown, JS1
Jørgensen, JT1
Hersom, M1
Benjamin, D1
Robay, D1
Hindupur, SK1
Pohlmann, J1
Colombi, M1
El-Shemerly, MY1
Maira, SM1
Moroni, C1
Lane, HA1
Hall, MN1
Jin, GB1
Hong, T1
Inoue, S1
Urano, T1
Cho, S1
Otsu, K1
Kitahara, M1
Ouchi, Y1
Cyong, JC1
Preobrazhenskiĭ, DV1
Sidorenko, BA1
Stetsenko, TM1
Kiktev, VG1
LANGEMANN, H1
GOERRE, J1
WEST, WL1
BAIRD, GM1
STEWARD, JD1
PRADHAN, SN1
WILLHEIM, R1
O'MALLEY, BB1
FLUSS, P1
DICKSON, J1
AUBER, M1
SHIONOYA, S1
CARLINI, GR1
FISCHER, GA1
GIARMAN, NJ3
LACASSAGNE, A1
VANORDEN, LS1
VUGMAN, I2
Van Orden, LS1
Bensch, KG1
Grossman, E3
Messerli, FH3
Goldbourt, U3
Marquardt, H1
Faigle, JW1
Dörhöfer, G1
Lapin, V1
Schmähl, D1
Muradian, RE1

Reviews

7 reviews available for reserpine and Neoplasms

ArticleYear
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member

2017
Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer.
    Neuroscience and biobehavioral reviews, 2022, Volume: 141

    Topics: Antipsychotic Agents; Chlorpromazine; Humans; Methylene Blue; Neoplasms; Phenothiazines; Reserpine;

2022
Clinical and Regulatory Aspects of Companion Diagnostic Development in Oncology.
    Clinical pharmacology and therapeutics, 2018, Volume: 103, Issue:6

    Topics: Antineoplastic Agents; Biological Assay; Drug Approval; Drug Development; Humans; Medical Oncology;

2018
[Antihypertensive drugs and malignant neoplasia].
    Kardiologiia, 2002, Volume: 42, Issue:5

    Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Age Factors; Aged; Angiotensin-Converting

2002
Carcinogenicity of cardiovascular drugs.
    Current hypertension reports, 1999, Volume: 1, Issue:3

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Brea

1999
Antihypertensive therapy and the risk of malignancies.
    European heart journal, 2001, Volume: 22, Issue:15

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aten

2001
Carcinogenicity of antihypertensive therapy.
    Current hypertension reports, 2002, Volume: 4, Issue:3

    Topics: Animals; Antihypertensive Agents; Breast Neoplasms; Carcinogens; Humans; Hypertension; Longitudinal

2002

Other Studies

17 other studies available for reserpine and Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic

2007
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.
    Cell reports, 2018, 12-11, Volume: 25, Issue:11

    Topics: Acids; Animals; Cell Line, Tumor; Energy Metabolism; Humans; Intracellular Space; Lactic Acid; Male;

2018
Reserpine.
    Report on carcinogens : carcinogen profiles, 2011, Volume: 12

    Topics: Adrenergic Uptake Inhibitors; Animals; Antihypertensive Agents; Humans; Neoplasms; Reserpine

2011
Augmentation of immune cell activity against tumor cells by Rauwolfia radix.
    Journal of ethnopharmacology, 2002, Volume: 81, Issue:3

    Topics: Animals; Blotting, Western; Cell Survival; Concanavalin A; Cytotoxicity, Immunologic; Female; Gene E

2002
[Suppression of hydroxyindole-acetic acid excretion in urine after reserpine administration in humans; with special consideration to carcinoid syndrome].
    Schweizerische medizinische Wochenschrift, 1957, May-25, Volume: 87, Issue:21

    Topics: Acetates; Carcinoid Tumor; Gastrointestinal Tract; Hydroxyindoleacetic Acid; Indoleacetic Acids; Mal

1957
Some studies on the anti-tumor effect of reserpine in mice.
    The Journal of pharmacology and experimental therapeutics, 1961, Volume: 131

    Topics: Animals; Antineoplastic Agents; Mice; Neoplasms; Neoplasms, Experimental; Reserpine

1961
FURTHER STUDIES CONCERNING CARCINOLYSIS.
    Experimental medicine and surgery, 1963, Volume: 21

    Topics: Animals; Antineoplastic Agents; Blood; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Mice; Neoplasms

1963
ELECTRON MICROSCOPIC STUDY ON THE CATECHOLAMINE METABOLISM IN THE HUMAN ADRENAL MEDULLA.
    Nagoya journal of medical science, 1963, Volume: 26

    Topics: Adrenal Medulla; Adrenalectomy; Arteriosclerosis Obliterans; Catecholamines; Disease; Electrons; Fem

1963
DIFFERENCES IN CHARACTERISTICS OF RELEASE OF SEROTONIN FROM NEOPLASTIC MAST CELLS IN CULTURE BY RESERPINE AND CHLORPROMAZINE.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 146

    Topics: Chlorpromazine; Mast Cells; Metabolism; Monoamine Oxidase Inhibitors; Neoplasms; Neoplasms, Experime

1964
[RELATIONS BETWEEN THE TUMOR AND ORGANISM. THE ROLE OF THE HYPOTHALAMUS].
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Chlorpromazine; Gold; Hypothalamus; Neoplasms; Neoplasms, Experimental; Neurophysiology; Pharmacolog

1964
5-HYDROXYTRYPTAMINE IN SINGLE NEOPLASTIC MAST CELLS: A MICROSCOPIC SPECTROFLUOROMETRIC STUDY.
    Science (New York, N.Y.), 1965, Apr-30, Volume: 148, Issue:3670

    Topics: Animals; Breast Neoplasms; Catecholamines; Fluorescence; Fluorometry; Histamine; Humans; Mammary Neo

1965
Biochemical, histochemical and electron-microscopic studies of 5-hydroxytryptamine in neoplastic mast cells.
    The Journal of pharmacology and experimental therapeutics, 1967, Volume: 158, Issue:2

    Topics: Acid Phosphatase; Animals; Cell Membrane; Clone Cells; Culture Techniques; Cytoplasm; Cytoplasmic Gr

1967
Letter: Reserpine and chemical carcinogenesis.
    Lancet (London, England), 1975, Apr-19, Volume: 1, Issue:7912

    Topics: Animals; Cell Transformation, Neoplastic; Culture Techniques; Mice; Neoplasms; Reserpine

1975
Letter: Reserpine and chemical carcinogenesis.
    Lancet (London, England), 1975, Mar-15, Volume: 1, Issue:7907

    Topics: Aldehydes; Benzoates; Biotransformation; Carcinogens; Cinnamates; Humans; Methyl Ethers; Neoplasms;

1975
Pineal influences on tumor.
    Progress in brain research, 1979, Volume: 52

    Topics: Animals; Animals, Newborn; Carcinogens; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental

1979
[Carcinogenic effect of reserpine?].
    Deutsche medizinische Wochenschrift (1946), 1978, Nov-17, Volume: 103, Issue:46

    Topics: Breast Neoplasms; Female; Humans; Neoplasms; Reserpine

1978
[Study of the potential carcinogenic activity of reserpine].
    Voprosy onkologii, 1986, Volume: 32, Issue:7

    Topics: Animals; Carcinogens; Female; Male; Mice; Neoplasms; Rats; Reserpine; Species Specificity

1986