reserpine has been researched along with Migraine Disorders in 52 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of many researches on migraine pathogenesis and our knowledge of the pharmacological action of reserpine led us to start using it in migraine prophylaxis ten years ago." | 6.64 | [Reserpine in the prevention of migraine and in the therapy of tension-vascular headache]. ( Brandi, G; Gastaldi, L; Lisino, F; Nattero, G, 1976) |
| " For hemicrania we used cinnarizine, cyproheptadine, clonidine, histamine, pizotifene and reserpine; for cluster headache, cinnarizine, cyproheptadine, clonidine, histamine and reserpine; for tension headache, cyproheptadine; for psychogenic headache, allylpropylmalonylurea." | 5.04 | [Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)]. ( Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G, 1975) |
| " In addition, number of humoral factors -- plasmakinin, serotonin, histamine -- intervene in the chain of events that culminates in migraine headache." | 4.75 | [Importance of humoral mediators for the pathogenesis and treatment of migraine (author's transl)]. ( Berde, B; Fanchamps, A, 1975) |
| "The results of many researches on migraine pathogenesis and our knowledge of the pharmacological action of reserpine led us to start using it in migraine prophylaxis ten years ago." | 2.64 | [Reserpine in the prevention of migraine and in the therapy of tension-vascular headache]. ( Brandi, G; Gastaldi, L; Lisino, F; Nattero, G, 1976) |
| "The concept that migraine results from an initial vasoconstriction due to increased release of noradrenaline from the sympathetic nerves to cranial blood vessels has been reappraised in the light of recently acquired knowledge of the mechanisms of action of drugs used in the treatment of migraine, physiological and pharmacological evidence implicating noradrenaline, and the observations by others that several migraine variants may be associated with some degree of sympathetic overactivity." | 2.36 | A basis for migraine therapy- the autonomic theory reappraised. ( Johnson, ES, 1978) |
| "A nitroglycerin-induced migraine model in rats and a reserpine-induced migraine model in mice were established to investigate the effects of RCXTAs on monoamine neurotransmitters in brain tissue, including 5-hydroxytryptamine (5-HT) and its metabolite (5-HIAA)." | 1.51 | Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT ( Feng, R; Luo, M; Peng, C; Pu, ZH; Xie, XF; Xiong, L; Zhu, H, 2019) |
| "In the migraine group, V waves were delayed significantly and consecutively I-V interpeak latencies were increased." | 1.28 | Brainstem auditory evoked potentials in migraine after Rausedyl provocation. ( Bánk, J, 1991) |
| "In control subjects without history of migraine, reserpine did not induce headache, and, furthermore, PET measurements 1 1/2 hours after drug administration consistently showed a global increase in RCMRGlu over resting values similar to that observed in a normal control (rest-rest) group not receiving reserpine." | 1.27 | Effect of reserpine on regional cerebral glucose metabolism in control and migraine subjects. ( Christman, DR; Russell, JA; Sachs, H; Wolf, A, 1986) |
| "At the present time ergotism is due primarily to excessive use or abuse of ergot preparations for migraine headaches." | 1.26 | Mesenteric and peripheral vascular ischemia secondary to ergotism. ( Ariyan, S; Greene, FL; Stansel, HC, 1977) |
| " The therapeutic cycles were standardized, for each drug, in the way of administration, dosage and total duration of the treatment." | 1.26 | [Therapeutic possibilities in idiopathic headaches. Analysis of about 1000 cases]. ( Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G, 1976) |
| "Some psychosomatic disorders, for example, bronchial asthma, peptic ulcer, and migraine headaches are perhaps more amenable to psychotherapy than others, for example, hypertension and ulcerative colitis." | 1.25 | Psychotherapy in psychosomatic disorders. ( Kellner, R, 1975) |
| "After migraine attack a very pronounced lowering in excretion rate of both 5-hydroxy-indoles occured." | 1.25 | Fluctuation of 5-hydroxy-indole compounds in the urine of migrainous patients. ( Deanović, Z; Dupelj, M; Iskrić, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (88.46) | 18.7374 |
| 1990's | 2 (3.85) | 18.2507 |
| 2000's | 2 (3.85) | 29.6817 |
| 2010's | 2 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pu, ZH | 1 |
| Peng, C | 1 |
| Xie, XF | 1 |
| Luo, M | 1 |
| Zhu, H | 1 |
| Feng, R | 1 |
| Xiong, L | 1 |
| Pan, X | 1 |
| Wang, M | 1 |
| Wu, Y | 1 |
| Lu, X | 1 |
| Shang, Y | 1 |
| Xu, Y | 1 |
| Zhai, Y | 1 |
| Li, J | 1 |
| Li, Z | 1 |
| Gong, M | 1 |
| GRAHAME, R | 2 |
| FEJER, A | 2 |
| FRIEDMAN, AP | 1 |
| SICUTERI, F | 4 |
| MICHELACCI, S | 1 |
| LOMBARDI, V | 1 |
| FRANCHI, G | 2 |
| SAMSON, M | 1 |
| Valdivia, LF | 2 |
| Centurión, D | 1 |
| Perusquía, M | 1 |
| Arulmani, U | 1 |
| Saxena, PR | 2 |
| Villalón, CM | 2 |
| Johnson, JM | 1 |
| Mück-Seler, D | 1 |
| Deanović, Z | 2 |
| Dupelj, M | 2 |
| Pattichis, K | 1 |
| Louca, LL | 1 |
| Jarman, J | 1 |
| Sandler, M | 1 |
| Glover, V | 1 |
| Willems, EW | 1 |
| Johnson, ES | 1 |
| Berde, B | 1 |
| Fanchamps, A | 1 |
| Nappi, G | 1 |
| Savoldi, F | 1 |
| Bono, G | 1 |
| Martignoni, E | 1 |
| Lechevalier, B | 1 |
| Leymarie, P | 1 |
| Nattero, G | 7 |
| Agostoni, A | 2 |
| Brandi, G | 4 |
| Cottino, A | 2 |
| Gai, V | 3 |
| Gastaldi, L | 5 |
| Lisino, F | 4 |
| Greene, FL | 1 |
| Ariyan, S | 1 |
| Stansel, HC | 1 |
| Genefke, IK | 4 |
| Bryndum, B | 3 |
| Dalsgaard-Nielsen, T | 3 |
| Fog-Moller, F | 3 |
| Jensen, JA | 1 |
| Kellner, R | 1 |
| Iskrić, S | 1 |
| Ziegler, DK | 2 |
| Ward, DF | 1 |
| Bánk, J | 1 |
| Savi, L | 1 |
| Sachs, H | 1 |
| Wolf, A | 1 |
| Russell, JA | 1 |
| Christman, DR | 1 |
| Cahen, RL | 1 |
| Carroll, JD | 1 |
| Hilton, BP | 4 |
| Ward, D | 1 |
| Hassanein, RS | 1 |
| Cumings, JN | 2 |
| Anthony, M | 6 |
| Hinterberger, H | 4 |
| Lance, JW | 5 |
| Curzon, G | 1 |
| Barrie, M | 1 |
| Wilkinson, MI | 1 |
| Tandon, RN | 1 |
| Sur, BK | 1 |
| Nath, K | 1 |
| Da Prada, M | 1 |
| Pletscher, A | 1 |
| Buffoni, F | 1 |
| Anselmi, B | 1 |
| Del Bianco, PL | 1 |
| Somerville, B | 1 |
| Vagholkar, MK | 1 |
| Piazza, A | 1 |
| Kimball, RW | 1 |
| Goodman, MA | 1 |
4 reviews available for reserpine and Migraine Disorders
| Article | Year |
|---|---|
THE PATHOGENESIS OF MIGRAINE HEADACHE.
Topics: Arteriovenous Fistula; Brain Diseases; Cerebrovascular Circulation; Histamine; Humans; Migraine Diso | 1963 |
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 1984 |
A basis for migraine therapy- the autonomic theory reappraised.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cats; Cerebral Arteries; Contrac | 1978 |
[Importance of humoral mediators for the pathogenesis and treatment of migraine (author's transl)].
Topics: Acetates; Animals; Blood Vessels; Cerebrovascular Circulation; Diet; Estrogens; Headache; Histamine; | 1975 |
4 trials available for reserpine and Migraine Disorders
| Article | Year |
|---|---|
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 1984 |
[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)].
Topics: Aspirin; Caffeine; Cinnarizine; Clinical Trials as Topic; Clonidine; Cyproheptadine; Drug Therapy, C | 1975 |
[Reserpine in the prevention of migraine and in the therapy of tension-vascular headache].
Topics: Headache; Humans; Migraine Disorders; Reserpine; Vascular Headaches | 1976 |
[The action of reserpine on the concentration of 5-hydroxytryptamine, epinephrine and norepinephrine in the venous blood of migraine patients].
Topics: Epinephrine; Humans; Migraine Disorders; Norepinephrine; Reserpine; Serotonin | 1976 |
45 other studies available for reserpine and Migraine Disorders
| Article | Year |
|---|---|
Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT
Topics: Alkaloids; Animals; Brain; Female; Hydroxyindoleacetic Acid; Ligusticum; Male; Mice; Migraine Disord | 2019 |
Identification of active ingredients in Wuzhuyu decoction improving migraine in mice by spectral efficiency association.
Topics: Animals; Brain; China; Drugs, Chinese Herbal; Ginsenosides; Humans; Indole Alkaloids; Limonins; Medi | 2015 |
Drug prophylaxis in migraine. A controlled clinical trial.
Topics: Humans; Migraine Disorders; Phenobarbital; Reserpine | 1960 |
[The treatment of vascular headache with Hirepin].
Topics: Chlorpromazine; Histamine; Migraine Disorders; Promethazine; Reserpine; Vascular Headaches | 1962 |
HIREPIN TREATMENT OF VASCULAR HEADACHE.
Topics: Chlorpromazine; Migraine Disorders; Promethazine; Reserpine; Vascular Headaches | 1963 |
COAGULATION CHANGES DURING MIGRAINE.
Topics: Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Tests; Fibrinolysin; Humans; Migra | 1963 |
[MEDICAL HEADACHES].
Topics: Aminophylline; Amphetamine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Barbiturates; Caffei | 1964 |
[SEROTONIN AND THE CENTRAL NERVOUS SYSTEM].
Topics: Brain Chemistry; Central Nervous System; Epilepsy; Humans; Infant, Newborn; Metabolism; Migraine Dis | 1964 |
Pharmacological analysis of the mechanisms involved in the tachycardic and vasopressor responses to the antimigraine agent, isometheptene, in pithed rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Decerebrate Stat | 2004 |
Serotonin-releasing factors in migrainous patients.
Topics: Adolescent; Adult; Biological Products; Blood Platelets; Female; Humans; Hydroxyindoleacetic Acid; M | 1982 |
5-Hydroxytryptamine release from platelets by different red wines: implications for migraine.
Topics: Blood Platelets; Color; Humans; In Vitro Techniques; Migraine Disorders; Reserpine; Serotonin; Wine | 1995 |
Pharmacological profile of the mechanisms involved in the external carotid vascular effects of the antimigraine agent isometheptene in anaesthetised dogs.
Topics: Anesthesia; Animals; Carotid Artery, External; Dogs; Hemodynamics; Methylamines; Migraine Disorders; | 2001 |
Hypothesis: migraine, a central biochemical dysnociception.
Topics: Adult; Animals; Apomorphine; Circadian Rhythm; Dopamine; Female; Fever; Headache; Humans; Levodopa; | 1976 |
Reserpine--headache and PRL release in migraine.
Topics: Adult; Female; Humans; Male; Migraine Disorders; Prolactin; Reserpine | 1979 |
[Biochemical interpretation of the migraine crisis].
Topics: Carotid Arteries; Female; Humans; Kidney; Male; Migraine Disorders; Reserpine; Serotonin | 1978 |
Mesenteric and peripheral vascular ischemia secondary to ergotism.
Topics: Adult; Arterial Occlusive Diseases; Dextrans; Ergotamine; Ergotism; Female; Femoral Artery; Humans; | 1977 |
[Therapeutic possibilities in idiopathic headaches. Analysis of about 1000 cases].
Topics: Cinnarizine; Clonidine; Cyproheptadine; Headache; Histamine; Humans; Methysergide; Migraine Disorder | 1976 |
Concentration of serotonin in blood platelets: effect of reserpine in migraineurs.
Topics: Adult; Blood Platelets; Female; Histocytochemistry; Humans; Male; Migraine Disorders; Reserpine; Ser | 1975 |
Psychotherapy in psychosomatic disorders.
Topics: Asthma; Behavior Therapy; Child; Colitis, Ulcerative; Eczema; Female; Humans; Hypertension; Hypnosis | 1975 |
Fluctuation of 5-hydroxy-indole compounds in the urine of migrainous patients.
Topics: Adolescent; Adult; Creatinine; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Migraine Disor | 1975 |
Therapeutic effect of reserpine on migraine syndrome: relationship to blood amine levels.
Topics: Adult; Epinephrine; Female; Humans; Migraine Disorders; Norepinephrine; Reserpine; Serotonin | 1976 |
Reserpine for migraine prophylaxis.
Topics: Humans; Migraine Disorders; Reserpine | 1976 |
Migraine, tyramine and blood serotonin.
Topics: Adult; Aged; Humans; Middle Aged; Migraine Disorders; Reserpine; Serotonin; Tyramine | 1976 |
Brainstem auditory evoked potentials in migraine after Rausedyl provocation.
Topics: Adult; Electromyography; Evoked Potentials, Auditory, Brain Stem; Female; Humans; Male; Middle Aged; | 1991 |
[Possibilities and limitations of the therapy of headache].
Topics: Adrenergic beta-Antagonists; Cluster Headache; Ergotamine; Headache; Humans; Migraine Disorders; Res | 1987 |
Effect of reserpine on regional cerebral glucose metabolism in control and migraine subjects.
Topics: Adult; Brain; Female; Glucose; Humans; Male; Middle Aged; Migraine Disorders; Reserpine; Tomography, | 1986 |
Emetic effect of biogenic amines.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain; Catecholamines; | 1970 |
Small blood-vessels in migraine.
Topics: Blood Vessels; Humans; Migraine Disorders; Reserpine | 1970 |
The effects of reserpine injection on methysergide treated control and migrainous subjects.
Topics: Adult; Depression, Chemical; Female; Humans; Male; Methysergide; Middle Aged; Migraine Disorders; Re | 1974 |
Correlation of whole blood serotonin with headache precipitated by tyramine or reserpine.
Topics: Humans; Migraine Disorders; Reserpine; Serotonin; Tyramine | 1974 |
Effects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects.
Topics: Blood Platelets; Carbon Radioisotopes; Cell Membrane; Chlorpromazine; Humans; Migraine Disorders; Pl | 1974 |
Effects of methysergide on platelets incubated with reserpine.
Topics: Blood Platelets; Bromine; Ergolines; Ergotamine; Humans; In Vitro Techniques; Methysergide; Migraine | 1971 |
Plasma serotonin in migraine and stress.
Topics: Cerebral Ventriculography; Diarrhea; Humans; Injections, Intramuscular; Injections, Intravenous; Mig | 1967 |
Relationships between headache and amine changes after administration of reserpine to migrainous patients.
Topics: Adolescent; Adult; Age Factors; Creatinine; Female; Headache; Humans; Hydroxyindoleacetic Acid; Inje | 1969 |
Effect of reserpine injections in migrainous and normal control subjects, with estimations of urinary 5-hydroxyindoleacetic acid.
Topics: Adult; Headache; Humans; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; Migraine Disorder | 1969 |
Uptake, metabolism, storage, and release of 5-hydroxytryptamine in blood platelets.
Topics: Adenosine Triphosphate; Amphetamine; Animals; Blood Platelets; Carbon Isotopes; Cell Membrane; Guine | 1970 |
An enzyme (MAO) defect on the platelets in migraine.
Topics: Benzyl Compounds; Blood Platelets; Carbon Isotopes; Humans; Metabolism, Inborn Errors; Migraine Diso | 1970 |
Thermographic, hormonal, and clinical studies in migraine.
Topics: Body Temperature; Cycloheptanes; Cyproheptadine; Ergolines; Female; Humans; Menstruation; Methysergi | 1970 |
Thermographic studies in vascular headache.
Topics: Adult; Headache; Humans; Middle Aged; Migraine Disorders; Reserpine; Serotonin; Skin Temperature; Th | 1971 |
An assessment of platelet aggregation induced by 5-hydroxytryptamine.
Topics: Adult; Age Factors; Aged; Aniline Compounds; Blood Platelets; Female; Humans; Imidazoles; Male; Meth | 1971 |
Serotonin and migraine.
Topics: Humans; Hydroxyindoleacetic Acid; Methysergide; Migraine Disorders; Norepinephrine; Reserpine; Serot | 1967 |
Platelet 5-hydroxytryptamine and adenine nucleotides, serum arginylesterase and plasma 11-hydroxycorticosteroids in migraine.
Topics: Adenine Nucleotides; Blood Platelets; Esterases; Glucocorticoids; Humans; Migraine Disorders; Reserp | 1968 |
Studies of serotonin metabolism in migraine.
Topics: Adenine Nucleotides; Blood Platelets; Culture Techniques; Humans; Migraine Disorders; Reserpine; Ser | 1968 |
[Study of "medical headaches". 6. Discussion of the relative incidence found with the reserpine induction test].
Topics: Headache; Humans; Italy; Migraine Disorders; Reserpine | 1968 |
Effects of reserpine on amino-acid excretion in patients with migraine.
Topics: Headache; Histidine; Humans; Migraine Disorders; Reserpine; Urine | 1966 |