reserpine has been researched along with Marfan Syndrome in 2 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Marfan Syndrome: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome (type 1) is associated with mutations in the gene encoding FIBRILLIN-1 (FBN1), a major element of extracellular microfibrils of connective tissue. Mutations in the gene encoding TYPE II TGF-BETA RECEPTOR (TGFBR2) are associated with Marfan syndrome type 2.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Storer, J | 1 |
| Husni, EA | 1 |
| Aseem, W | 1 |
| Murdoch, JL | 1 |
| Walker, BA | 1 |
| Halpern, BL | 1 |
| Kuzma, JW | 1 |
| McKusick, VA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Thoracic Aortic Dilatation Syndromes - Diagnostic, Incidences, Morbidity, Mortality and Socioeconomical Observations.[NCT02111668] | 120 participants (Actual) | Observational [Patient Registry] | 2013-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for reserpine and Marfan Syndrome
| Article | Year |
|---|---|
Management of thoracic aneurysms.
Topics: Aneurysm; Angiography; Aorta, Thoracic; Aortic Diseases; Diatrizoate; Guanethidine; Humans; Marfan S | 1967 |
Life expectancy and causes of death in the Marfan syndrome.
Topics: Adolescent; Adult; Age Factors; Aged; Aortic Diseases; Cardiovascular Diseases; Child; Female; Human | 1972 |