reserpine has been researched along with Leukemia P388 in 4 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epirubicin is a derivative of doxorubicin having more favourable therapeutic index than doxorubicin and possessing less hematologic and cardiac toxicity at comparable doses." | 1.29 | Sensitization of P388 murine leukemia cells to epirubicin cytotoxicity by reserpine. ( Chitnis, M; Viladkar, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inaba, M | 1 |
| Fujikura, R | 1 |
| Tsukagoshi, S | 1 |
| Sakurai, Y | 1 |
| Viladkar, A | 1 |
| Chitnis, M | 1 |
| Nakamura, S | 1 |
| Wakusawa, S | 1 |
| Tajima, K | 1 |
| Miyamoto, K | 1 |
| Hagiwara, M | 1 |
| Hidaka, H | 1 |
| Shibata, H | 1 |
| Furusawa, S | 1 |
| Kawauchi, H | 1 |
| Sasaki, K | 1 |
| Takayanagi, Y | 1 |
4 other studies available for reserpine and Leukemia P388
| Article | Year |
|---|---|
Restored in vitro sensitivity of adriamycin- and vincristine-resistant P388 leukemia with reserpine.
Topics: Animals; Cells, Cultured; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mice; | 1981 |
Sensitization of P388 murine leukemia cells to epirubicin cytotoxicity by reserpine.
Topics: Animals; DNA, Neoplasm; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Dr | 1993 |
Effects of isoquinolinesulphonamide compounds on multidrug-resistant P388 cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; C | 1993 |
[Modulation of anthracycline resistance by reserpine in P388 leukemia cells].
Topics: Animals; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Leukemia P388; Mice; Reserp | 1991 |