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reserpine and Hypothyroidism

reserpine has been researched along with Hypothyroidism in 32 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.

Research Excerpts

ExcerptRelevanceReference
"To investigate the mechanism of the antagonistic effect of Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L-prolin amide monohydrate (CAS 131404-34-7, JTP-2942) on reserpine-induced hypothermia, the role of the autonomic nervous system, adrenal gland, and thyroid gland regarding the effects of JTP-2942 has been studied in mice."7.69Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia. ( Iwata, K; Matsushita, M; Ohta, A; Yonemori, F, 1995)
"To investigate the mechanism of the antagonistic effect of Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L-prolin amide monohydrate (CAS 131404-34-7, JTP-2942) on reserpine-induced hypothermia, the role of the autonomic nervous system, adrenal gland, and thyroid gland regarding the effects of JTP-2942 has been studied in mice."3.69Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia. ( Iwata, K; Matsushita, M; Ohta, A; Yonemori, F, 1995)
"This study was designed to determine the effect of neonatally-produced hypothyroidism on reserpine-elicited tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (D beta H) induction in the superior cervical ganglion (SCG) in rats."3.68Tyrosine hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu- and hypothyroid rats. ( Blouquit, MF; Chami, N; de Lonlay, A; Edwards, DA; Gripois, D; Valens, M, 1991)
"In contrast, hypothyroidism has practically no effect on brainstem dopamine beta-hydroxylase induction."1.27Developmental pattern of dopamine beta-hydroxylase induction in the adrenals of the rat. Influence of neonatal hypothyroidism. ( Chami, N; Gripois, D, 1988)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199028 (87.50)18.7374
1990's2 (6.25)18.2507
2000's1 (3.13)29.6817
2010's1 (3.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Menezes, EC1
Santos, PR1
Goes, TC1
Carvalho, VCB1
Teixeira-Silva, F1
Stevens, HE1
BadauĂȘ-Passos, DJ1
Zaninovich, AA1
Rebagliati, I1
Raices, M1
Ricci, C1
Hagmuller, K1
DE FELICE, EA2
DEARBORN, EH2
SMITH, TC2
MASCITELLI-CORIANDOLI, E1
DE GENNES, JL1
TRUFFERT, J1
PRANGE, AJ1
CHIBA, N1
KLEIN, JJ1
SEGAL, RL1
WARNER, RR1
GAYET-HALLION, T1
BOUVET, P1
NUTTALL, FQ1
DOE, RP1
PEARCE, A1
Hirano, A1
Hashimoto, H2
Nakashima, M2
Matsushita, M1
Yonemori, F1
Ohta, A1
Iwata, K1
Okajima, F1
Ui, M1
Simon, KH1
de Lonlay, A1
Blouquit, MF1
Valens, M1
Chami, N3
Edwards, DA1
Gripois, D3
Niho, T1
Adashi, EY1
Katz, E1
Ho, KY1
Evans, WS1
Thorner, MO1
Strubelt, O1
Steffen, J1
Stutz, U1
Ruiz-Torres, A1
McDougall, IR1
Greig, WR1
Winkelmann, W1
MoratĂ” Manaro, J1
Silverman, LH1
Beznak, M1
Kako, KJ1
Kusakabe, T1
Braunwald, E2
Sonnenblick, EH2
Spann, JF2
Buccino, RA2
Bhagat, B1
Saini, N1
West, WL1
Booker, WM1
Winter, D1

Reviews

4 reviews available for reserpine and Hypothyroidism

ArticleYear
Diagnostic work-up of hyperprolactinemic disorders.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1988, Volume: 2, Issue:4

    Topics: Antipsychotic Agents; Cimetidine; Estrogens; Female; Humans; Hyperprolactinemia; Hypothyroidism; Mag

1988
Disorders of prolactin and growth hormone secretion.
    Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:1

    Topics: Acromegaly; Arginine; Clonidine; Dwarfism; Female; Glucose Tolerance Test; Growth Hormone; Growth Ho

1985
Pathogenesis and treatment of thyrotoxicosis.
    Scottish medical journal, 1971, Volume: 16, Issue:12

    Topics: Adult; Child; Chlordiazepoxide; Diazepam; Eye Manifestations; Female; Glucocorticoids; Graves Diseas

1971
[Current status of our knowledge on prolactin].
    Revista argentina de endocrinologia y metabolismo, 1970, Volume: 16, Issue:4

    Topics: Adult; Amenorrhea; Animals; Birds; Endocrine System Diseases; Female; Fibrous Dysplasia of Bone; Gro

1970

Other Studies

28 other studies available for reserpine and Hypothyroidism

ArticleYear
Effects of a rat model of gestational hypothyroidism on forebrain dopaminergic, GABAergic, and serotonergic systems and related behaviors.
    Behavioural brain research, 2019, 07-02, Volume: 366

    Topics: Amygdala; Animals; Anxiety; Anxiety Disorders; Disease Models, Animal; Dopamine; Dopaminergic Neuron

2019
Mitochondrial respiration in muscle and liver from cold-acclimated hypothyroid rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:4

    Topics: Adipose Tissue, Brown; Adrenergic Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Weight; C

2003
Effect of reserpine (Serpasil) on oxygen consumption of euthyroid, hypothyroid, and hyperthyroid guinea pigs.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1957, Volume: 94, Issue:1

    Topics: Animals; Guinea Pigs; Hyperthyroidism; Hypothyroidism; Oxygen Consumption; Reserpine; Thyroid Functi

1957
Effect of reserpine (Serpasil) on oxygen consumption of euthyroid, hypothyroid, and hyperthyroid guinea pigs.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1957, Volume: 94, Issue:1

    Topics: Animals; Guinea Pigs; Hyperthyroidism; Hypothyroidism; Oxygen Consumption; Reserpine; Thyroid Functi

1957
Effect of reserpine (Serpasil) on oxygen consumption of euthyroid, hypothyroid, and hyperthyroid guinea pigs.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1957, Volume: 94, Issue:1

    Topics: Animals; Guinea Pigs; Hyperthyroidism; Hypothyroidism; Oxygen Consumption; Reserpine; Thyroid Functi

1957
Effect of reserpine (Serpasil) on oxygen consumption of euthyroid, hypothyroid, and hyperthyroid guinea pigs.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1957, Volume: 94, Issue:1

    Topics: Animals; Guinea Pigs; Hyperthyroidism; Hypothyroidism; Oxygen Consumption; Reserpine; Thyroid Functi

1957
[Reserpine in experimental thyreotoxicosis: its action on the adenosine nucleotide of heart tissues].
    Experientia, 1960, Dec-15, Volume: 16

    Topics: Adenosine; Heart; Hypothyroidism; Myocardium; Nucleotides; Reserpine

1960
[ISOTOPE TESTS OF RADIO-THYROXIN HALF-LIFE AND IN VITRO ERYTHROCYTE FIXATION OF LABELLED TRIIODOTHYRONINE].
    Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1963, May-31, Volume: 114

    Topics: Anorexia Nervosa; Erythrocytes; Goiter; Graves Disease; Half-Life; Hypercholesterolemia; Hyperthyroi

1963
THE PHARMACOLOGY AND BIOCHEMISTRY OF DEPRESSION.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Amitriptyline; Antidepressive Agents; Biochemical Phenomena; Biochemistry; Brain; Depression; Depres

1964
[STUDIES OF THE URINARY 5-HYDROXYINDOLEACETIC ACID WITH SPECIAL REFERENCE TO CASES WITH THYROID DISORDERS].
    Tohoku igaku zasshi, 1963, Volume: 67

    Topics: Acute Kidney Injury; Hydroxyindoleacetic Acid; Hypertension; Hyperthyroidism; Hypothyroidism; Indole

1963
GALACTORRHEA DUE TO IMIPRAMINE. REPORT OF A CASE.
    The New England journal of medicine, 1964, Sep-03, Volume: 271

    Topics: Amenorrhea; Chlorpromazine; Depression; Depressive Disorder; Female; Galactorrhea; Humans; Hypothyro

1964
[ACTION OF THE BLOOD OF ETHYROID HORSES ON THE TOXICITY OF THE AMPHETAMINE GROUP. COMPARISON WITH NORMAL HORSE BLOOD AND WITH RESERPINE].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1964, Volume: 158

    Topics: Amphetamine; Amphetamines; Animals; Blood Transfusion; Horses; Hypothyroidism; Mice; Pharmacology; R

1964
THE ACHILLES REFLEX IN THYROID DISORDERS; A CRITICAL EVALUATION.
    Annals of internal medicine, 1964, Volume: 61

    Topics: Achilles Tendon; Adrenocorticotropic Hormone; Aging; Anemia; Anemia, Pernicious; Aspirin; Cold Tempe

1964
PITFALLS IN THE DIAGNOSIS OF PSYCHIATRIC DISEASE.
    The Practitioner, 1965, Volume: 194

    Topics: Anxiety; Anxiety Disorders; Brain Neoplasms; Carcinoid Tumor; Depression; Diagnosis; Drug Therapy; G

1965
Influence of hypothyroid status on dopamine-induced positive chronotropic and inotropic effects on isolated rat atria.
    Japanese journal of pharmacology, 1982, Volume: 32, Issue:2

    Topics: Animals; Dopamine; Heart Rate; Hypothyroidism; In Vitro Techniques; Male; Myocardial Contraction; Ph

1982
Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:6

    Topics: Adrenal Medulla; Animals; Body Temperature; Hexamethonium; Hypothermia; Hypothyroidism; Male; Mice;

1995
Metabolism of glucose in hyper- and hypo-thyroid rats in vivo. Relation of catecholamine actions to thyroid activity in controlling glucose turnover.
    The Biochemical journal, 1979, Aug-15, Volume: 182, Issue:2

    Topics: Animals; Blood Glucose; Catecholamines; Epinephrine; Hydroxydopamines; Hyperthyroidism; Hypothyroidi

1979
[News from the control of thoughts].
    Medizinische Monatsschrift, 1975, Volume: 29, Issue:2

    Topics: Central Nervous System; Cognition; Depression; Humans; Hypothyroidism; Lithium; Reserpine; Tryptopha

1975
Tyrosine hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu- and hypothyroid rats.
    Journal of the autonomic nervous system, 1991, Volume: 36, Issue:1

    Topics: Aging; Animals; Dopamine beta-Hydroxylase; Ganglia, Sympathetic; Hypothyroidism; Rats; Rats, Inbred

1991
Influence of hypothyroidism on the ontogenic development of tyrosine hydroxylase induction in the adrenal glands of the rat.
    Archives internationales de physiologie et de biochimie, 1989, Volume: 97, Issue:1

    Topics: Adrenal Glands; Age Factors; Animals; Chlorisondamine; Dactinomycin; Enzyme Induction; Female; Hypot

1989
Effects of 2-[(5-chloro-2-methoxyphenyl) azo]-1H-imidazole (M6434) on alpha adrenergic receptors.
    Japanese journal of pharmacology, 1987, Volume: 45, Issue:4

    Topics: Animals; Arteries; Dogs; Heart; Hypothyroidism; Imidazoles; In Vitro Techniques; Male; Muscle, Smoot

1987
Developmental pattern of dopamine beta-hydroxylase induction in the adrenals of the rat. Influence of neonatal hypothyroidism.
    Journal of developmental physiology, 1988, Volume: 10, Issue:5

    Topics: Adrenal Glands; Animals; Brain Stem; Congenital Hypothyroidism; Dopamine beta-Hydroxylase; Enzyme In

1988
[Influence of thyroid gland function on the chronotropic and some metabolic actions of theophylline and caffeine].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 267, Issue:2

    Topics: Adenylyl Cyclases; Adrenal Medulla; Animals; Blood Glucose; Caffeine; Enzyme Activation; Fatty Acids

1970
[Iatrogenic hypothyroidism].
    Medizinische Klinik, 1971, Oct-29, Volume: 66, Issue:44

    Topics: Aminosalicylic Acids; Antithyroid Agents; Goiter; History, 18th Century; History, 19th Century; Hist

1971
[Diagnosis and immediate therapy of the endocrine crisis].
    Der Internist, 1970, Volume: 11, Issue:2

    Topics: Adrenal Insufficiency; Diabetic Coma; Emergencies; Endocrine System Diseases; Glucose; Humans; Hydro

1970
Effect of reserpine and triiodothyronine on myocardial lipoprotein lipase, metabolic rate and plasma free fatty acids in rats.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 199, Issue:2

    Topics: Animals; Drug Interactions; Fatty Acids, Nonesterified; Hypothyroidism; Injections, Intramuscular; I

1972
[Hypothyroidism (including Hashimoto's disease)].
    Naika. Internal medicine, 1971, Volume: 27, Issue:6

    Topics: Aged; Anemia; Coma; Female; Humans; Hypothyroidism; Male; Middle Aged; Myxedema; Reserpine; Thyroid

1971
Effects of heart failure, ventricular hypertrophy, and alterations in the thyroid state on the contractility of isolated cardiac muscle.
    Annals of the New York Academy of Sciences, 1969, Jan-31, Volume: 156, Issue:1

    Topics: Animals; Cardiomyopathies; Cats; Heart; Heart Diseases; Hyperthyroidism; Hypertrophy; Hypothyroidism

1969
Effect of thyroid state on myocardial contractility.
    Endocrinology, 1968, Volume: 82, Issue:1

    Topics: Animals; Biomechanical Phenomena; Cats; Heart; Hyperthyroidism; Hypothyroidism; In Vitro Techniques;

1968
Modification of action of sympathomimetic amines by triiodothyronine.
    Archives internationales de pharmacodynamie et de therapie, 1965, Volume: 155, Issue:1

    Topics: Animals; Blood; Blood Pressure; Cocaine; Heart; Hyperthyroidism; Hypothyroidism; Myocardium; Norepin

1965
[Experimental contribution to the role of the thyroid gland in modification of reactivity of the body to medication. Modification of the toxicity of some psychotropic drugs in animals with induced hyperthyroidism and hypothyroidism].
    Studii si cercetari de endocrinologie, 1966, Volume: 17, Issue:5

    Topics: Amphetamine; Animals; Chlordiazepoxide; Drug Hypersensitivity; Hyperthyroidism; Hypothyroidism; Imip

1966