Compounds > reserpine
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reserpine and Hypertension, Malignant

reserpine has been researched along with Hypertension, Malignant in 42 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Hypertension, Malignant: A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.

Research Excerpts

ExcerptRelevanceReference
"In order to study the role of elastin in arteries with respect to hypertension and hypertensive arterial disease, aortic elastin content and elastase-like enzyme activity were examined and compared in stroke-prone spontaneously hypertensive rats (SHRSP), which show malignant hypertension, and Wistar-Kyoto normotensive rats (WKY)."7.67Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. ( Daniel, EE; Ito, H; Kwan, CY, 1987)
"In order to study the role of elastin in arteries with respect to hypertension and hypertensive arterial disease, aortic elastin content and elastase-like enzyme activity were examined and compared in stroke-prone spontaneously hypertensive rats (SHRSP), which show malignant hypertension, and Wistar-Kyoto normotensive rats (WKY)."3.67Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. ( Daniel, EE; Ito, H; Kwan, CY, 1987)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199042 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
BUSSOLATI, C1
STURUP, H2
GRUNER, A2
HILDEN, T1
KROGSGAARD, AR1
VIMTRUP, B1
SOMERS, K1
MISHCHENKO, PI1
KAPLAN, NM1
RAPADOERRAZTI, A1
JIMENEZCASADO, M1
RODICIODIAZ, JL1
PEDERSEN, J1
LINDENEG, O1
FISCHER, S1
SEBRANJOBRIZ, F1
GILL, JR1
GEORGE, JM1
SOLOMON, A1
BARTTER, FC1
Moyer, JH2
Woods, JW2
Haas, Th1
Denkl, P1
Fleischmann, LE1
Mroczek, WJ1
Brodwall, EK1
Flatmark, A1
Curry, CL1
Ito, H1
Kwan, CY1
Daniel, EE1
Seedat, YK1
Redgrave, JE1
Swartz, SL1
Perret, C1
Girardet, P1
Munro, AB1
Philipp, T1
Nast, HP1
Mühlberg, H1
Mühlberg, G1
Batson, HM1
Birchall, R1
Weber, GF1
Bock, KD2
Mashaly, M1
el-Ebrashy, N1
Higazi, AM1
el-Din Moustafa, S1
Abul-Einen, M1
Spach, MO1
Imbs, JL1
Schwartz, J1
Freis, ED1
Ahearn, DJ1
Grim, CE1
Froment, R1
Froment, A1
Zech, P1
Tucker, RM1
Hunt, JC1
Vaamonde, CA1
David, NJ1
Palmer, RF1
Finnerty, FA1
Hagino, K1
Junker, P1
Bechgaard, P1
Esch, I1
Repetto, S1
Rezzonico, A1
Gervasini, N1

Reviews

5 reviews available for reserpine and Hypertension, Malignant

ArticleYear
Drug systems approach to hypertension.
    Pennsylvania medicine, 1984, Volume: 87, Issue:5

    Topics: Captopril; Clonidine; Drug Combinations; Drug Therapy, Combination; Guanethidine; Humans; Hydralazin

1984
[Treatment of the hypertensive crisis].
    Schweizerische medizinische Wochenschrift, 1973, Nov-24, Volume: 103, Issue:47

    Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Pressure; Diaz

1973
Present day management of hypertension.
    Southern medical journal, 1974, Volume: 67, Issue:7

    Topics: Acute Kidney Injury; Angiography; Antihypertensive Agents; Aortic Aneurysm; Diet, Sodium-Restricted;

1974
Recent advances in the medical and surgical treatment of hypertension.
    The Medical clinics of North America, 1968, Volume: 52, Issue:5

    Topics: Adrenocortical Hyperfunction; Antihypertensive Agents; Diet, Sodium-Restricted; Diuretics; Ethacryni

1968
Hypertensive emergencies.
    The Medical clinics of North America, 1971, Volume: 55, Issue:2

    Topics: Brain Diseases; Guanethidine; Hypertension, Malignant; Kidney; Reserpine; Trimethaphan

1971

Trials

1 trial available for reserpine and Hypertension, Malignant

ArticleYear
[Ambulant long-term treatment of arterial hypertension].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1965, Aug-01, Volume: 20, Issue:15

    Topics: Animals; Antihypertensive Agents; Chlorothiazide; Clinical Trials as Topic; Diuretics; Female; Gangl

1965

Other Studies

36 other studies available for reserpine and Hypertension, Malignant

ArticleYear
[Effects of reserpine on chronic malignant hypertension].
    Gazzetta medica italiana, 1954, Volume: 113, Issue:10

    Topics: Alkaloids; Humans; Hypertension; Hypertension, Malignant; Hypnotics and Sedatives; Rauwolfia; Reserp

1954
[Combined medication over a long period in severe non-malignant hypertension].
    Ugeskrift for laeger, 1957, Oct-03, Volume: 119, Issue:40

    Topics: Aged; Humans; Hydralazine; Hypertension; Hypertension, Malignant; Muscle Relaxants, Central; Reserpi

1957
[Fatal pulmonary changes during medical treatment of malignant hypertension].
    Nordisk medicin, 1958, Mar-06, Volume: 59, Issue:10

    Topics: Autonomic Agents; Hypertension; Hypertension, Malignant; Lung Diseases; Reserpine

1958
Long-term combined drug therapy in non-malignant hypertension.
    Acta medica Scandinavica, 1958, Mar-17, Volume: 160, Issue:3

    Topics: Cardiovascular Agents; Hydralazine; Hypertension; Hypertension, Malignant; Muscle Relaxants, Central

1958
Mecamylamine and reserpine in the management of severe and malignant hypertension in Uganda.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1959, Jun-20, Volume: 33, Issue:25

    Topics: Autonomic Agents; Disease Management; Hypertension; Hypertension, Malignant; Mecamylamine; Reserpine

1959
[The effect of reserpine (serpasil) on kidney function in malignant hypertension].
    Terapevticheskii arkhiv, 1961, Volume: 33

    Topics: Hypertension, Malignant; Kidney; Reserpine

1961
PRIMARY ALDOSTERONISM WITH MALIGNANT HYPERTENSION.
    The New England journal of medicine, 1963, Dec-12, Volume: 269

    Topics: Adenoma; Adrenal Gland Neoplasms; Chlorothiazide; Corticosterone; Humans; Hydrocortisone; Hyperaldos

1963
[RESULTS OBTAINED IN THE TREATMENT OF ARTERIAL HYPERTENSION WITH THE ASSOCIATION OF A NEW THIAZIDE DIURETIC (POLYTHIAZIDE) AND RESERPINE].
    Revista clinica espanola, 1963, Dec-31, Volume: 91

    Topics: Benzothiadiazines; Diuretics; Hypertension; Hypertension, Malignant; Hypertension, Renal; Kidney; Ph

1963
[ACUTE MALIGNANT HYPERTENSION WITH SECONDARY ALDOSTERONISM. A CASE IN A 31-YEAR-OLD MAN WITH CONGENITAL UNILATERAL RENAL HYPOPLASIA].
    Ugeskrift for laeger, 1964, Jan-16, Volume: 126

    Topics: Alkalosis; Antihypertensive Agents; Blood Chemical Analysis; Congenital Abnormalities; Guanethidine;

1964
[TREATMENT OF HYPERTENSION WITH HYGROTON-RESERPINE].
    Medicina clinica, 1963, Volume: 41

    Topics: Arteriosclerosis; Chlorthalidone; Clinical Laboratory Techniques; Electrocardiography; Guanethidine;

1963
HYPERALDOSTERONISM AND RENAL SODIUM LOSS REVERSED BY DRUG TREATMENT FOR MALIGNANT HYPERTENSION.
    The New England journal of medicine, 1964, May-21, Volume: 270

    Topics: Blood Chemical Analysis; Chlorambucil; Guanethidine; Humans; Hydralazine; Hyperaldosteronism; Hypert

1964
Use of sympatholytic and vasodilator drugs.
    Pennsylvania medicine, 1984, Volume: 87, Issue:1

    Topics: Adrenergic beta-Antagonists; Clonidine; Diuretics; Drug Therapy, Combination; Guanethidine; Humans;

1984
Malignant hypertension: clinical recognition and management.
    Cardiovascular clinics, 1978, Volume: 9, Issue:1

    Topics: Adult; Diazoxide; Female; Humans; Hydralazine; Hypertension; Hypertension, Malignant; Kidney; Male;

1978
[Therapy of hypertensive crises].
    Fortschritte der Medizin, 1977, Apr-21, Volume: 95, Issue:15

    Topics: Acute Disease; Adrenal Gland Neoplasms; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazine

1977
Management of hypertensive crisis in children.
    Pediatric annals, 1977, Volume: 6, Issue:6

    Topics: Acute Disease; Adolescent; Cerebrovascular Disorders; Child; Child, Preschool; Diazoxide; Humans; Hy

1977
Malignant hypertension.
    Angiology, 1977, Volume: 28, Issue:7

    Topics: Diazoxide; Diuretics; Humans; Hydralazine; Hypertension, Malignant; Kidney; Nephrectomy; Nitroprussi

1977
[Treatment of malignant hypertension].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Apr-30, Volume: 96, Issue:12

    Topics: Adolescent; Adult; Diazoxide; Humans; Hydralazine; Hypertension, Malignant; Male; Reserpine

1976
Current treatment of malignant hypertension.
    JAMA, 1975, Jun-30, Volume: 232, Issue:13

    Topics: Acute Disease; Administration, Oral; Antihypertensive Agents; Blood Pressure; Diazoxide; Diuretics;

1975
Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension.
    Experimental and molecular pathology, 1987, Volume: 47, Issue:1

    Topics: Aging; Animals; Aorta; Blood Pressure; Cell Membrane; Elastin; Hydralazine; Hypertension, Malignant;

1987
Patient with malignant hypertension alive after 25 years. A case report.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Nov-22, Volume: 70, Issue:11

    Topics: Adult; Chlorothiazide; Drug Therapy, Combination; Follow-Up Studies; Guanethidine; Humans; Hydralazi

1986
Diagnosis and management of malignant hypertension.
    Comprehensive therapy, 1985, Volume: 11, Issue:3

    Topics: Antihypertensive Agents; Female; Humans; Hydralazine; Hypertension, Malignant; Kidney Function Tests

1985
[Hypertensive emergencies].
    Der Internist, 1974, Volume: 15, Issue:3

    Topics: Brain Edema; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Drug Combinations; Emergencies;

1974
Hypertension: current trends in diagnosis and treatment.
    Geriatrics, 1967, Volume: 22, Issue:11

    Topics: Aortic Coarctation; Azides; Cushing Syndrome; Ganglionic Blockers; Humans; Hydrazines; Hyperaldoster

1967
[Conservative treatment of hypertension].
    Munchener medizinische Wochenschrift (1950), 1970, Nov-20, Volume: 112, Issue:47

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aniline Compounds; Dihydroxyphenylalanine; Female; Guaneth

1970
The treatment of malignant hypertension and hypertensive emergencies. A statement by the AMA committee on hypertension.
    JAMA, 1974, Jun-24, Volume: 228, Issue:13

    Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Diazoxide; Drug Evaluation; Emergenci

1974
Dietary sodium restriction and natriuresis in management of hypertension.
    The Journal of the Egyptian Medical Association, 1974, Volume: 57, Issue:1-2

    Topics: Adult; Aged; Benzothiadiazines; Diet, Sodium-Restricted; Diuretics; Ethacrynic Acid; Female; Furosem

1974
[Malignant nephroangiosclerosis. Development and treatment].
    La Nouvelle presse medicale, 1972, Sep-16, Volume: 1, Issue:32

    Topics: Adult; Aniline Compounds; Antihypertensive Agents; Cerebrovascular Disorders; Diagnosis, Differentia

1972
Hypertension: challenge in preventive medicine.
    Preventive medicine, 1973, Volume: 2, Issue:1

    Topics: Aged; Aneurysm; Cardiovascular Diseases; Cerebral Hemorrhage; Cerebrovascular Disorders; Drug Therap

1973
Treatment of malignant hypertension with sodium nitroprusside.
    Archives of internal medicine, 1974, Volume: 133, Issue:2

    Topics: Administration, Oral; Adult; Aged; Blood Pressure; Chemical Phenomena; Chemistry; Diazoxide; Drug Re

1974
[Respective roles of hemodynamic or humoral factors and of hypotensive or salidiuretic drugs in the development of essential hypertension].
    Pathologie et biologie, 1965, Volume: 13, Issue:21

    Topics: Adult; Chlorthalidone; Diet, Sodium-Restricted; Electrocardiography; Guanethidine; Humans; Hydrochlo

1965
[What is reliable in the therapy of hypertension?].
    Der Internist, 1970, Volume: 11, Issue:12

    Topics: Arteriosclerosis; Cerebral Hemorrhage; Diet, Reducing; Diet, Sodium-Restricted; Guanethidine; Health

1970
Hypertensive encephalopathy.
    The American journal of medicine, 1972, Volume: 52, Issue:5

    Topics: Anxiety; Brain Diseases; Brain Edema; Coma; Diazoxide; Female; Furosemide; Glomerulonephritis; Heada

1972
[Hypertension--malignant hypertension].
    Naika. Internal medicine, 1971, Volume: 27, Issue:6

    Topics: Diuretics; Hexamethonium Compounds; Humans; Hydrazines; Hypertension, Malignant; Male; Methyldopa; M

1971
[Malignant hypertension. A case with survival for 20 years during antihypertensive therapy].
    Ugeskrift for laeger, 1971, Dec-17, Volume: 133, Issue:50

    Topics: Aged; Bendroflumethiazide; Biopsy; Electrocardiography; Humans; Hypertension, Malignant; Male; Ophth

1971
[Effect of a combination of ergot alkaloids, reserpine and salidiuretics in the therapy of hypertension].
    Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1968, Volume: 49, Issue:8

    Topics: Adult; Amides; Antihypertensive Agents; Clopamide; Diuretics; Ergot Alkaloids; Female; Humans; Hyper

1968
[Considerations on ambulatory therapy in a group of hypertensive patients].
    Minerva medica, 1969, Jun-27, Volume: 60, Issue:51

    Topics: Adult; Aged; Ambulatory Care; Carbamates; Female; Guanethidine; Humans; Hydralazine; Hydrochlorothia

1969