reserpine has been researched along with Huntington Disease in 32 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tetrabenazine (TBZ) is a monoamine-depleting agent initially studied in the 1950s and currently approved by the US Food and Drug Administration for the treatment of chorea in Huntington's disease." | 6.46 | Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. ( Guay, DR, 2010) |
| " Tetrabenazine (TBZ) is a non-competitive inhibitor of VMAT2 that is used in the treatment of hyperkinetic disorders associated with Huntington disease and Tourette syndrome." | 3.79 | Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine. ( Gros, Y; Schuldiner, S; Segal, T; Ugolev, Y; Yaffe, D, 2013) |
| "Tetrabenazine (TBZ) is a monoamine-depleting agent initially studied in the 1950s and currently approved by the US Food and Drug Administration for the treatment of chorea in Huntington's disease." | 2.46 | Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. ( Guay, DR, 2010) |
| "Huntington's disease (Huntington's chorea), a degenerative disorder of the central nervous system, is inherited in an autosomal dominant pattern." | 1.26 | Huntington's disease: current concepts of therapy. ( Goetz, CG; Weiner, WJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (93.75) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ugolev, Y | 1 |
| Segal, T | 1 |
| Yaffe, D | 1 |
| Gros, Y | 1 |
| Schuldiner, S | 1 |
| Guay, DR | 1 |
| LAZARTE, JA | 1 |
| PETERSEN, MC | 1 |
| BAARS, CW | 1 |
| PEARSON, JS | 1 |
| FARBROT, O | 2 |
| WALTHER-BUEL, H | 2 |
| GRUNG, P | 1 |
| SUNDBY, P | 1 |
| FORREST, AD | 1 |
| VORISEK, V | 1 |
| HACKSTEIN, FG | 1 |
| ZMORSKI, T | 1 |
| CHHUTTANI, PN | 1 |
| SINGH, S | 1 |
| SHTERNBERG, EIa | 1 |
| SMULEVICH, AB | 1 |
| MARKHAM, CH | 1 |
| CLARK, WG | 1 |
| WINTERS, WD | 1 |
| WARICK, LH | 1 |
| BARROWS, HS | 1 |
| MACKIEWICZ, J | 1 |
| REID, AA | 1 |
| CHANDLER, JH | 1 |
| KEMPINSKY, WH | 1 |
| BONIFACE, WR | 1 |
| MORGAN, PP | 1 |
| BUSCH, AK | 1 |
| Hays, SE | 1 |
| Goodwin, FK | 1 |
| Paul, SM | 1 |
| Rosin, AJ | 1 |
| Goetz, CG | 1 |
| Weiner, WJ | 1 |
| Klawans, HL | 1 |
| Haerer, AF | 1 |
| Currier, RD | 1 |
| Jackson, JF | 1 |
| Curzon, G | 1 |
| Whittier, JR | 1 |
| Korenyi, C | 1 |
| Ottosson, JO | 1 |
| Rapp, W | 1 |
| Hartmann-von Monakow, K | 1 |
| Calabrese, VP | 1 |
| Candelise, L | 1 |
| Faglioni, P | 1 |
| Spinnler, H | 1 |
| Vignolo, LA | 1 |
| Constantinidis, J | 1 |
| Chase, TN | 1 |
| Marsden, CD | 1 |
4 reviews available for reserpine and Huntington Disease
| Article | Year |
|---|---|
Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Cytochrome P | 2010 |
Chorea.
Topics: Antipsychotic Agents; Cholinergic Fibers; Chorea; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid | 1987 |
The biochemistry of dyskinesias.
Topics: Acetylcholine; Animals; Catecholamines; Cats; Copper; Dihydroxyphenylalanine; Dogs; Hepatolenticular | 1967 |
Serotonergic mechanisms and extrapyramidal function in man.
Topics: 5-Hydroxytryptophan; Carbidopa; Cerebellar Diseases; Creutzfeldt-Jakob Syndrome; Down Syndrome; Extr | 1974 |
1 trial available for reserpine and Huntington Disease
| Article | Year |
|---|---|
Letter: Treatment of Huntington's chorea.
Topics: Amantadine; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Clinical Trials as Topic; Dia | 1973 |
27 other studies available for reserpine and Huntington Disease
| Article | Year |
|---|---|
Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding Sites; Biological Transport, Active; HEK293 Cells; Hu | 2013 |
Huntington's chorea: results of treatment with reserpine.
Topics: Antihypertensive Agents; Humans; Huntington Disease; Reserpine; Secologanin Tryptamine Alkaloids | 1955 |
[Reserpine with Huntington's chorea; report of two cases].
Topics: Humans; Huntington Disease; Reserpine | 1956 |
[Reserpine with Huntington's chorea; report of two cases].
Topics: Humans; Huntington Disease; Reserpine | 1956 |
[Reserpine with Huntington's chorea; report of two cases].
Topics: Humans; Huntington Disease; Reserpine | 1956 |
[Reserpine with Huntington's chorea; report of two cases].
Topics: Humans; Huntington Disease; Reserpine | 1956 |
The action of neuroleptic drugs in Huntington's disease.
Topics: Chlorpromazine; Humans; Huntington Disease; Reserpine | 1956 |
The action of neuroleptic drugs in Huntington's disease.
Topics: Chlorpromazine; Humans; Huntington Disease; Reserpine | 1956 |
The action of neuroleptic drugs in Huntington's disease.
Topics: Chlorpromazine; Humans; Huntington Disease; Reserpine | 1956 |
The action of neuroleptic drugs in Huntington's disease.
Topics: Chlorpromazine; Humans; Huntington Disease; Reserpine | 1956 |
[Treatment of Huntington's chorea].
Topics: Humans; Huntington Disease; Reserpine | 1957 |
Some observations on Huntington's chorea.
Topics: Humans; Huntington Disease; Reserpine | 1957 |
[Reserpine treatment of Huntington's chorea & other extrapyramidal syndromes].
Topics: Basal Ganglia Diseases; Disease; Extrapyramidal Tracts; Humans; Huntington Disease; Reserpine; Syndr | 1958 |
[Limitations of treatment of Huntington's chorea & double athetosis with reserpine].
Topics: Athetosis; Humans; Huntington Disease; Reserpine | 1958 |
[Reserpine (serpasin) in therapy of Huntington's chorea].
Topics: Humans; Huntington Disease; Reserpine | 1959 |
Reserpine in Huntington's chorea.
Topics: Humans; Huntington Disease; Reserpine | 1959 |
[Experience in the use of neuroleptic substances in chronic progressive chorea (Huntington's chorea)].
Topics: Antipsychotic Agents; Chorea; Humans; Huntington Disease; Perphenazine; Reserpine | 1963 |
EFFECT OF ALPHA-METHYL DOPA AND RESERPINE IN HUNTINGTON'S CHOREA, PARKINSON'S DISEASE AND OTHER MOVEMENT DISORDERS.
Topics: Adolescent; Chorea; Dystonia Musculorum Deformans; Dystonic Disorders; Genetic Diseases, X-Linked; H | 1963 |
TREATMENT OF HUNTINGTON'S CHOREA WITH CHLORDIAZEPOXIDE (LIBRIUM).
Topics: Ataxia; Black People; Chlordiazepoxide; Chorea; Geriatrics; Huntington Disease; Meprobamate; Reserpi | 1964 |
CLINICAL AND NEUROPATHOLOGICAL INVESTIGATIONS OF FOUR CASES OF HUNTINGTON'S CHOREA TREATED WITH HIGH DOSES OF RESERPINE.
Topics: Basal Ganglia; Chorea; Drug Therapy; Ganglia; Humans; Huntington Disease; Medulla Oblongata; Nervous | 1965 |
Reserpine in the treatment of Huntington's chorea.
Topics: Antihypertensive Agents; Humans; Huntington Disease; Reserpine; Secologanin Tryptamine Alkaloids | 1955 |
Reserpine in Huntington's chorea.
Topics: Chorea; Huntington Disease; Reserpine | 1960 |
Cholecystokinin receptors in brain: effects of obesity, drug treatment, and lesions.
Topics: Amphetamine; Animals; Brain; Caudate Nucleus; Fasting; Humans; Huntington Disease; In Vitro Techniqu | 1981 |
Treatment of dyskinetic and choreatic movement disorders in adults.
Topics: Adult; Aged; Athetosis; Chorea; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskine | 1978 |
Huntington's disease: current concepts of therapy.
Topics: Acetylcholine; Adolescent; Adult; Butyrophenones; Child; Chlorpromazine; Dopamine Antagonists; gamma | 1979 |
Editorial: Dopamine and G.A.B.A. in Huntington's chorea.
Topics: Aminobutyrates; Blood Platelets; Brain; Butyrophenones; Dopamine; gamma-Aminobutyric Acid; Humans; H | 1974 |
Hereditary nonprogressive chorea of early onset.
Topics: Adolescent; Cerebral Ventriculography; Child; Chromosomes; Electroencephalography; Female; Humans; H | 1967 |
Effect of oral fluphenazine on Huntington's chorea.
Topics: Age Factors; Aged; Chronic Disease; Female; Fluphenazine; Humans; Huntington Disease; Male; Mental P | 1968 |
Serum levels of phenylalanine and tyrosine in Huntington's chorea.
Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents; Body Weight; Dopamine; Female; Humans; Hun | 1971 |
[Specific therapy of extrapyramidal-motor syndromes].
Topics: Analgesics; Athetosis; Chorea; Datura stramonium; Dihydroxyphenylalanine; Dystonia Musculorum Deform | 1969 |
Reserpine action in Huntington's chorea.
Topics: Aminobutyrates; Brain Chemistry; Humans; Huntington Disease; Reserpine | 1973 |
[Monoamines and choreic syndromes].
Topics: Amines; Butyrophenones; Chorea; Diazepam; Dihydroxyphenylalanine; Dopamine; Ganglia; Globus Pallidus | 1972 |
Drug treatment of diseases characterized by abnormal movements.
Topics: Chorea; Diazepam; Ethanol; Haloperidol; Humans; Huntington Disease; Levodopa; Movement Disorders; My | 1973 |