Page last updated: 2024-11-06

reserpine and Heart Failure

reserpine has been researched along with Heart Failure in 61 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

Excerpt	Relevance	Reference
"Reserpine treatment led to decreased NE re-uptake at 1d and 5d compared to saline treatment."	1.46	Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter. ( Buss, SJ; Haass, M; Katus, HA; Kreusser, MM; Lehmann, LH; Lossnitzer, D, 2017)

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	58 (95.08)	18.7374
1990's	1 (1.64)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (3.28)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jacobson, AF	1
Travin, MI	1
Kreusser, MM	1
Lehmann, LH	1
Haass, M	1
Buss, SJ	1
Katus, HA	1
Lossnitzer, D	1
MARLEY, E	1
PARE, CM	1
MEIER, R	1
BRUNI, C	1
TRIPOD, J	1
SCHUMANN, H	1
MECIANI, L	1
GUITELMAN, A	1
CHIDSEY, CA	2
BRAUNWALD, E	2
MORROW, AG	1
MASON, DT	2
HARRISON, DC	1
GAFFNEY, TE	1
KAHLER, RL	1
JAMES, JA	1
FINK, CW	1
WEAVER, KH	1
NARYCHEV, AA	1
DREIZINA, AM	1
RIPKA, O	1
PERCHIKOVA, GE	1
Finnerty, FA	1
Davidov, M	1
Kakaviatos, N	1
Wendlandt, S	1
Varma, DR	1
Matsumoto, T	1
Brandt, D	1
Freis, E	1
Huang, TY	1
Pang, XQ	1
Ch'ang, HL	1
Sole, MJ	1
Wurtman, RJ	1
Lo, CM	1
Kamble, AB	1
Sonnenblick, EH	2
Alousi, AA	2
Farah, AE	1
Lesher, GY	1
Opalka, CJ	1
Enenkel, W	1
Miyagishima, Y	1
Romankiewicz, JA	1
Vichi, FL	1
de Oliveira, AC	1
Fariña, FR	1
Bernardes F, J	1
Martins, JD	1
Mazotti, L	1
Fiorentini, C	3
Olivari, MT	1
Polese, A	3
Magrini, F	3
Moruzzi, P	1
Guazzi, M	3
Ikeda, J	1
Haneda, T	1
Kanda, H	1
Hiramoto, T	1
Furuyama, M	1
Sakuma, T	1
Shirato, K	1
Takishima, T	1
Perry, LW	1
Hung, W	1
Carlier, J	1
Gilbert, JW	1
Berglund, E	1
Dahlgren, S	1
Ovenfors, CO	1
Barnes, R	1
Sakai, K	1
Sugano, S	1
Isono, C	1
Bock, KD	2
Freis, ED	2
Dalen, JE	1
Alpert, JS	1
Cohn, LH	1
Black, H	1
Collins, JJ	1
Amery, A	1
Fagard, R	1
Misotten, A	1
Koch-Weser, J	1
Fernandes, M	1
Kim, KE	1
Moyer, JH	1
Laidlaw, JC	1
Grossman, A	1
Ramanathan, K	1
Fresco, R	1
Lüllmann, H	1
Schaefer, J	1
Girndt, J	1
Kramer, P	1
Scheler, F	1
Spann, JF	1
Zelis, R	1
DeGroot, WJ	1
Leonard, JJ	1
Britov, AN	1
Siderskiĭ, AL	1
Stephan, E	1
Arora, RB	1
Bagchi, N	1
Gupta, OP	1
Hilliard, CC	1
Bagwell, EE	1
Daniell, HB	1
Freeman, BF	1
Bartorelli, C	1
Attar, S	1
Fardin, R	1
Ayella, R	1
McLaughlin, JS	1
Feola, M	1
Haiderer, O	1
Kennedy, JH	1
Fidelle, J	1
Cloup, M	1
Nouaille, J	1
Glick, G	1
Parmley, WW	1
Wechsler, AS	1
Fizel', A	1
Fizel'ová, A	1

Reviews

11 reviews available for reserpine and Heart Failure

Article	Year
Impact of medications on mIBG uptake, with specific attention to the heart: Comprehensive review of the literature. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2015, Volume: 22, Issue:5 Topics: 3-Iodobenzylguanidine; Amines; Amiodarone; Animals; Anti-Arrhythmia Agents; Antidepressive Agents, T	2015
STUDIES ON THE FUNCTION OF THE ADRENERGIC NERVE ENDINGS IN THE HEART. Circulation, 1963, Volume: 28 Topics: Adrenergic Agents; Biochemical Phenomena; Biochemistry; Guanethidine; Heart; Heart Failure; Heart Fu	1963
[Therapy of hypertensive crisis]. Wiener medizinische Wochenschrift (1946), 1980, May-31, Volume: 130, Issue:10 Topics: Acute Disease; Bed Rest; Cardiac Glycosides; Clonidine; Diazoxide; Dihydralazine; Diuretics; Heart F	1980
[Cardiac therapy in the old patient]. Wiener medizinische Wochenschrift (1946), 1979, Oct-10, Volume: 129, Issue:18 Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Body Water; Calcium; Clonidine; Digitalis Glycos	1979
Pharmacology and clinical use of drugs in hypertensive emergencies. American journal of hospital pharmacy, 1977, Volume: 34, Issue:2 Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Aorta; Brain Diseases; Cerebral Hemorrhage; Diazox	1977
Effectiveness of drug therapy in hypertension: present status. A review. Circulation research, 1971, Volume: 28, Issue:5 Topics: Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Eye Diseases; Ganglionic Block	1971
Correlation of pathophysiology and pharmacotherapy in primary hypertension. The American journal of cardiology, 1973, Sep-20, Volume: 32, Issue:4 Topics: Blood Pressure; Cardiac Output; Cardiac Volume; Diuretics; Furosemide; Guanethidine; Heart Failure;	1973
Hypertensive emergencies. Pennsylvania medicine, 1974, Volume: 77, Issue:7 Topics: Acute Kidney Injury; Adrenal Gland Neoplasms; Antihypertensive Agents; Aortic Aneurysm; Blood Volume	1974
New developments in the understanding of the actions of the digitalis glycosides. Progress in cardiovascular diseases, 1969, Volume: 11, Issue:6 Topics: Animals; Blood Circulation; Calcium; Digitalis Glycosides; Drug Synergism; Heart; Heart Diseases; He	1969
Hyperthyroidism as a high cardiac output state. American heart journal, 1970, Volume: 79, Issue:2 Topics: Cardiac Output; Electrocardiography; Heart Failure; Heart Function Tests; Heart Rate; Hemodynamics;	1970
[Gastro-duodenal disorders in patients with cardiovascular diseases]. Kardiologiia, 1971, Volume: 11, Issue:8 Topics: Adrenal Cortex Hormones; Animals; Arteriosclerosis; Cardiovascular Diseases; Cats; Cerebrovascular D	1971

Trials

3 trials available for reserpine and Heart Failure

Article	Year
[Current state of the treatment of arterial hypertension]. Cardiology, 1980, Volume: 66 Suppl 2 Topics: Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Heart Failure; Humans; Hydralazine	1980
Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects. Circulation, 1972, Volume: 45, Issue:5 Topics: Adult; Age Factors; Aged; Aneurysm; Atrial Fibrillation; Blood Glucose; Blood Pressure; Cerebrovascu	1972
Hypertension: a challenge in preventive medicine. Journal of the Royal College of Physicians of London, 1974, Volume: 9, Issue:1 Topics: Age Factors; Attitude to Health; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disea	1974

Other Studies

47 other studies available for reserpine and Heart Failure

Article	Year
Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter. PloS one, 2017, Volume: 12, Issue:3 Topics: Animals; Catecholamines; Down-Regulation; Echocardiography; Heart; Heart Failure; Heart Rate; Male;	2017
Cardiac failure with reserpine. British medical journal, 1956, Feb-04, Volume: 1, Issue:4961 Topics: Antihypertensive Agents; Heart Failure; Humans; Reserpine; Secologanin Tryptamine Alkaloids	1956
[Pharmacodynamic differentiation of apresoline, serpasil and chlorpromazine by their effect on water retention in the rat]. Archives internationales de pharmacodynamie et de therapie, 1955, Dec-01, Volume: 104, Issue:2 Topics: Animals; Antihypertensive Agents; Chlorpromazine; Heart Failure; Hydralazine; Kidney; Rats; Reserpin	1955
[Therapy of hemodynamic and coronary insufficiency of the heart]. Arztliche Forschung, 1958, Mar-10, Volume: 12, Issue:3 Topics: Bradycardia; Coronary Artery Disease; Heart; Heart Failure; Hemodynamics; Humans; Reserpine	1958
[Clinical data on the combined acetyldigitoxin & reserpine therapy of circulatory decompensation]. La Clinica terapeutica, 1959, Volume: 16, Issue:3 Topics: Acetyldigitoxins; Digitalis; Heart Failure; Plant Extracts; Reserpine	1959
[Cardiac insufficiency. Its treatment with reserpine]. Prensa medica argentina, 1960, Sep-23, Volume: 47 Topics: Heart Failure; Humans; Reserpine	1960
MYOCARDIAL NOREPINEPHRINE CONCENTRATION IN MAN. EFFECTS OF RESERPINE AND OF CONGESTIVE HEART FAILURE. The New England journal of medicine, 1963, Sep-26, Volume: 269 Topics: Cardiac Surgical Procedures; Heart Failure; Metabolism; Myocardium; Norepinephrine; Pharmacology; Re	1963
ACUTE GLOMERULONEPHRITIS. Clinical pediatrics, 1964, Volume: 3 Topics: Blood Chemical Analysis; Child; Convalescence; Edema; Electrocardiography; Erythromycin; Glomerulone	1964
THE HEART AND ACUTE GLOMERULONEPHRITIS. Maryland state medical journal, 1964, Volume: 13 Topics: Child; Diet, Sodium-Restricted; Digitalis Glycosides; Drug Therapy; Glomerulonephritis; Heart Diseas	1964
[COMBINED PREOPERATIVE PREPARATION OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH HYPERTHYROIDISM]. Khirurgiia, 1964, Volume: 40 Topics: Cardiovascular System; Diuretics; Drug Therapy; Heart Failure; Humans; Hyperthyroidism; Preoperative	1964
[CLINICAL EVALUATION OF METHOXYPHENOSERPINE, A SYNTHETIC DERIVATIVE OF RESERPINE]. Cor et vasa, 1965, Volume: 7 Topics: Biomedical Research; Drug Therapy; Geriatrics; Heart Failure; Hypertension; Placebos; Proteinuria; R	1965
[Treatment of cardiac insufficiency with reserpine and ganglion-blocking agents especially in patients with hypertension]. Sovetskaia meditsina, 1960, Volume: 24 Topics: Ganglionic Blockers; Heart Failure; Humans; Hypertension; Reserpine; Vascular Diseases	1960
Hypertensive vascular disease. The long term effect of rapid repeated reductions of arterial pressure with diazoxide. The American journal of cardiology, 1967, Volume: 19, Issue:3 Topics: Adult; Chlorthalidone; Diazoxide; Female; Heart Failure; Humans; Hydralazine; Hypertension; Injectio	1967
Influence of reserpine, heart failure, and immunosympathectomy on the cardiac effects of ouabain. Canadian journal of physiology and pharmacology, 1967, Volume: 45, Issue:4 Topics: Adrenalectomy; Animals; Blood Pressure; Cats; Female; Heart; Heart Failure; Male; Norepinephrine; Ou	1967
[Studies on catecholamine, with special reference to cardiac failure. (3). Reaction and significance of urinary active catechols on administration of various autonomic substances in cardiac failure]. Japanese circulation journal, 1967, Volume: 31, Issue:3 Topics: Catechols; Epinephrine; Heart Failure; Heart Valve Diseases; Hepatitis; Humans; Neuritis; Norepineph	1967
Prophylactic effect of reserpine in cardiac failure caused by monofluoroacetic acid derivatives. Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:1 Topics: Animals; Citrates; Glycine; Heart Failure; Myocardium; Rabbits; Reserpine	1980
Tyrosine hydroxylase activity in the heart of the cardiomyopathic syrian hamster. Journal of molecular and cellular cardiology, 1977, Volume: 9, Issue:3 Topics: Animals; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Female; Heart Failure;	1977
Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one]. Circulation research, 1979, Volume: 45, Issue:5 Topics: Adenosine Triphosphatases; Adrenergic beta-Antagonists; Aminopyridines; Anesthesia; Animals; Blood P	1979
[Catecholamine in the myocardium; a fluorescence histochemical study]. Japanese circulation journal, 1975, Volume: 39, Issue:3 Topics: Animals; Atrioventricular Node; Cardiomegaly; Catecholamines; Dogs; Heart Atria; Heart Block; Heart	1975
[Bumetanide in the treatment of congestive heart failure and arterial hypertension]. Arquivos brasileiros de cardiologia, 1978, Volume: 31, Issue:4 Topics: Body Weight; Bumetanide; Diuresis; Diuretics; Drug Therapy, Combination; Heart Failure; Humans; Hype	1978
[Functional response of the hypertensive decompensated heart to the removal of adrenergic effects]. Bollettino della Societa italiana di cardiologia, 1976, Volume: 21, Issue:11 Topics: Adult; Aged; Guanethidine; Heart Failure; Humans; Hypertension; Male; Middle Aged; Propranolol; Rese	1976
Cardiovascular effects of dopamine in the normal and failing heart of experimental animals. Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6 Topics: Animals; Atropine; Blood Pressure; Cricetinae; Dogs; Dopamine; Dopamine Antagonists; Female; Guinea	1975
Influence of reduced presynaptic myocardial norepinephrine stores on left ventricular contractility. Journal of the autonomic nervous system, 1991, Jun-15, Volume: 34, Issue:2-3 Topics: Animals; Blood Pressure; Dogs; Electric Stimulation; Heart Failure; Heart Rate; Myocardial Contracti	1991
Atrial fibrillation and hyperthyroidism in a 14-year-old body. The Journal of pediatrics, 1971, Volume: 79, Issue:4 Topics: Adolescent; Antithyroid Agents; Atrial Fibrillation; Digitalis Glycosides; Diuretics; Electrocardiog	1971
[Treatment of cardiac complications in hyperthyroidism]. Revue medicale de Liege, 1973, Sep-01, Volume: 28, Issue:17 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Digitalis Glycosides; Guanethidine; Heart Disease	1973
Experimental pulmonary hypertension in the dog. A preparation involving repeated air embolism. The Journal of thoracic and cardiovascular surgery, 1968, Volume: 55, Issue:4 Topics: Animals; Ascites; Blood Pressure; Cardiac Catheterization; Cardiomegaly; Dogs; Embolism, Air; Heart	1968
Effects of oxyfedrine and ouabain on the heart-lung preparation of the dog. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 277, Issue:1 Topics: Amino Alcohols; Animals; Arrhythmias, Cardiac; Cardiac Output; Disease Models, Animal; Dogs; Female;	1973
[Conservative treatment of hypertension]. Munchener medizinische Wochenschrift (1950), 1970, Nov-20, Volume: 112, Issue:47 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aniline Compounds; Dihydroxyphenylalanine; Female; Guaneth	1970
Dissection of the thoracic aorta. Medical or surgical therapy? The American journal of cardiology, 1974, Volume: 34, Issue:7 Topics: Adult; Aged; Aorta, Thoracic; Aortic Aneurysm; Aortic Valve Insufficiency; Autonomic Agents; Blood P	1974
[Indications of antihypertensive treatment in non-malignant hypertension]. Revue medicale de la Suisse romande, 1974, Volume: 94, Issue:8 Topics: Antihypertensive Agents; Aortic Aneurysm; Benzothiadiazines; Cerebrovascular Disorders; Coronary Dis	1974
Importance of the adrenergic nervous system in the support of cardiac function in patients with primary arterial hypertension. Clinical science and molecular medicine. Supplement, 1973, Volume: 45 Suppl 1 Topics: Body Weight; Cardiac Output; Chlorthalidone; Digitalis Glycosides; Glomerular Filtration Rate; Guane	1973
Role of the sympathetic nervous system in supporting cardiac function in essential arterial hypertension. British heart journal, 1973, Volume: 35, Issue:1 Topics: Adult; Aged; Blood Pressure; Digitalis; Diuretics; Guanethidine; Heart; Heart Failure; Heart Rate; H	1973
Acute glomerulonephritis with minimal urinary abnormalities presenting as hypertension. Clinical pediatrics, 1973, Volume: 12, Issue:4 Topics: Acute Disease; Biopsy; Blood Cell Count; Child; Child, Preschool; Diagnosis, Differential; Edema; Gl	1973
[Acute left heart failure, pulmonary edema]. Deutsche medizinische Wochenschrift (1946), 1973, Volume: 98, Issue:43 Topics: Acute Disease; Aged; Furosemide; Heart Failure; Humans; Lanatosides; Male; Morphine; Oxygen Inhalati	1973
Hypertension: challenge in preventive medicine. Preventive medicine, 1973, Volume: 2, Issue:1 Topics: Aged; Aneurysm; Cardiovascular Diseases; Cerebral Hemorrhage; Cerebrovascular Disorders; Drug Therap	1973
[Severe hypertension with cardiac failure and nephrosclerosis after oral contraceptives (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1974, Mar-01, Volume: 99, Issue:9 Topics: Adult; Antihypertensive Agents; Cardiac Catheterization; Contraceptives, Oral; Digoxin; Dyspnea; Ele	1974
[What is reliable in the therapy of hypertension?]. Der Internist, 1970, Volume: 11, Issue:12 Topics: Arteriosclerosis; Cerebral Hemorrhage; Diet, Reducing; Diet, Sodium-Restricted; Guanethidine; Health	1970
[Slowing down of the heart over a long period by reserpine . (Remote results in a series of cases of irreducible chronic cardiac insufficiency following myocardial infarct)]. Archives des maladies du coeur et des vaisseaux, 1965, Volume: 58, Issue:6 Topics: Adult; Heart Failure; Humans; Middle Aged; Myocardial Infarction; Reserpine	1965
The effects of reserpine and propranolol on the therapeutic and toxic effects of peruvoside in the heart-lung preparation and intact dogs. The Indian journal of medical research, 1972, Volume: 60, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Cardanolides; Cardiac Glycosides; Dogs; Drug Antagonism; Extracorpore	1972
The effects of reserpine on the cardiovascular responses to phentolamine. Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 196, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Aorta; Blood Pressure; Cardiovascular System; Dogs; Drug Antagonism	1972
[Cardiac insufficiency appearing in essential arterial hypertension]. Bulletin de l'Academie royale de medecine de Belgique, 1972, Volume: 12, Issue:2 Topics: Chlorthalidone; Guanethidine; Heart Failure; Humans; Hypertension; Reserpine	1972
Medical vs surgical treatment of acute dissecting aneurysms. Archives of surgery (Chicago, Ill. : 1960), 1971, Volume: 103, Issue:5 Topics: Acute Disease; Acute Kidney Injury; Adult; Aged; Aortic Aneurysm; Aortic Rupture; Aortography; Blood	1971
Experimental graded "pump failure" of the left ventricle. The Journal of surgical research, 1971, Volume: 11, Issue:7 Topics: Animals; Aorta, Thoracic; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Cardiac Output; Cardi	1971
[Prolonged supraventricular ectopic tachycardia in the child. (16 cases)]. Annales de pediatrie, 1969, Nov-02, Volume: 16, Issue:11 Topics: Arrhythmia, Sinus; Child; Child, Preschool; Digoxin; Electrocardiography; Electroconvulsive Therapy;	1969
Report of the panels on cardiovascular drugs from the drug efficacy study. Circulation, 1970, Volume: 41, Issue:1 Topics: Angina Pectoris; Cardiovascular Diseases; Chlorothiazide; Digitalis Glycosides; Drug Industry; Drug	1970
Glucagon. Its enhancement of cardiac performance in the cat and dog and persistence of its inotropic action despite beta-receptor blockade with propranolol. Circulation research, 1968, Volume: 22, Issue:6 Topics: Animals; Blood Pressure; Catecholamines; Cats; Dogs; Glucagon; Heart; Heart Atria; Heart Failure; He	1968
[Experimental studies of some metabolic processes of the failing heart. IX. Participation of the cholinergic mechanism in the radiographic, electrocardiographic and metabolic changes in the course of chronic constriction of the aorta, and after applicatio Zeitschrift fur Kreislaufforschung, 1966, Volume: 55, Issue:5 Topics: Acetylcholine; Animals; Aorta; Bradycardia; Cholinesterase Inhibitors; Diphtheria Toxin; Glycogen; H	1966