reserpine and Glioma
reserpine has been researched along with Glioma in 9 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 7.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| "Reserpine was found to enhance the effect of ACNU on ACNU-resistant C6 glioma (C6/ACNU)." | 7.67 | [Enhanced effect of reserpine on growth-inhibitory action of ACNU on ACNU resistance C6 glioma]. ( Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1984) |
| "Reserpine was shown to enhance the cytotoxicity of ACNU in both C6 and C6/ACNU rat glioma cells in vitro and also to enhance the chemotherapeutic effect of ACNU in C6/ACNU-bearing rats (C6/ACNU meningeal gliomatosis rats), in which ACNU resistance could be partially overcome by reserpine." | 7.67 | [Overcoming of ACNU resistance in a subline of rat glioma in vitro and in vivo by reserpine]. ( Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| "Reserpine was found to enhance the cytotoxicity of ACNU on ACNU-resistant C6 glioma (C6/ACNU) cells in vitro." | 7.67 | Enhanced effect of reserpine upon growth-inhibitory action of ACNU on ACNU-resistant C6 glioma. ( Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| "Reserpine enhanced in vitro the cytotoxicity of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) in both the C6 glioma and its ACNU-resistant subline, C6/ACNU." | 7.67 | Modulation in vitro and in vivo of ACNU resistance in a subline of C6 glioma with reserpine. ( Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1987) |
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 3.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| "Reserpine was found to enhance the effect of ACNU on ACNU-resistant C6 glioma (C6/ACNU)." | 3.67 | [Enhanced effect of reserpine on growth-inhibitory action of ACNU on ACNU resistance C6 glioma]. ( Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1984) |
| "Reserpine was shown to enhance the cytotoxicity of ACNU in both C6 and C6/ACNU rat glioma cells in vitro and also to enhance the chemotherapeutic effect of ACNU in C6/ACNU-bearing rats (C6/ACNU meningeal gliomatosis rats), in which ACNU resistance could be partially overcome by reserpine." | 3.67 | [Overcoming of ACNU resistance in a subline of rat glioma in vitro and in vivo by reserpine]. ( Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| "Reserpine was found to enhance the cytotoxicity of ACNU on ACNU-resistant C6 glioma (C6/ACNU) cells in vitro." | 3.67 | Enhanced effect of reserpine upon growth-inhibitory action of ACNU on ACNU-resistant C6 glioma. ( Hayakawa, T; Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
| "Reserpine enhanced in vitro the cytotoxicity of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) in both the C6 glioma and its ACNU-resistant subline, C6/ACNU." | 3.67 | Modulation in vitro and in vivo of ACNU resistance in a subline of C6 glioma with reserpine. ( Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1987) |
| "Membrane-modifying agents such as reserpine, calcium antagonists (nicardipine, verapamil) and calmodulin inhibitor (trifluoperazine) were found to enhance the cytotoxicity of ACNU in vitro and in vivo in ACNU-resistant C 6 (C 6/ACNU) glioma." | 3.67 | [Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma]. ( Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T, 1986) |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wang, W | 1 |
| Tabu, K | 1 |
| Hagiya, Y | 1 |
| Sugiyama, Y | 1 |
| Kokubu, Y | 1 |
| Murota, Y | 1 |
| Ogura, SI | 1 |
| Taga, T | 1 |
| Yoshida, T | 7 |
| Shimizu, K | 7 |
| Ushio, Y | 7 |
| Hayakawa, T | 5 |
| Mogami, H | 7 |
| Sakamoto, Y | 7 |
| Lysko, PG | 1 |
| Henneberry, RC | 1 |
Other Studies
9 other studies available for reserpine and Glioma
| Article | Year |
|---|---|
Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biotransforma | 2017 |
[Enhanced effect of reserpine on growth-inhibitory action of ACNU on ACNU resistance C6 glioma].
Topics: Animals; Brain Neoplasms; DNA Repair; Drug Resistance; Drug Synergism; Glioma; Growth Inhibitors; Ni | 1984 |
[Enhancing effect of reserpine upon the cytotoxicity of ACNU on ACNU-resistant glioma cells].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Membrane Permeability; Cells, C | 1986 |
Differentiation between amine transport and beta-adrenergic receptor-mediated binding in cultured mammalian cells.
Topics: Adenosine Triphosphate; Amines; Binding, Competitive; Biological Transport, Active; Carrier Proteins | 1985 |
[Overcoming of ACNU resistance in a subline of rat glioma in vitro and in vivo by reserpine].
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Drug Resistance; Drug Synergism; Gliom | 1986 |
Enhanced effect of reserpine upon growth-inhibitory action of ACNU on ACNU-resistant C6 glioma.
Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Drug Syn | 1986 |
Modulation in vitro and in vivo of ACNU resistance in a subline of C6 glioma with reserpine.
Topics: Animals; Brain Neoplasms; Cell Line; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Gli | 1987 |
[Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Drug T | 1986 |
The mechanism and overcoming of resistance in ACNU-resistant sublines of C6 and 9L rat glioma.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Membrane Permeability; Dinitrophenols; Drug Resistan | 1987 |