reserpine has been researched along with Fibrosarcoma in 6 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diethylaminoreserpine (DL-152), an inhibitor of cyclic AMP phosphodiesterase, has been shown to kill clonogenic cells of the KHT fibrosarcoma when the drug is given intraperitoneally to the tumour-bearing mouse." | 3.66 | Toxicity to tumour cells of diethylaminoreserpine. ( Lehnert, S, 1980) |
| " DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay." | 1.27 | Factors influencing the toxicity of diethylaminoethylreserpine to tumor cells: studies with four transplantable tumors. ( Lehnert, S, 1987) |
| "Reserpine treatment decreased the growth of both tumors, whether unseparated or tumor-cell-enriched, and whether injected into the foot or the flank." | 1.26 | I. Tumor growth in mice with depressed capacity to mount inflammatory responses: possible role of macrophages. ( Hopper, KE; Nelson, DS; Nelson, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lehnert, S | 4 |
| Nelson, M | 2 |
| Nelson, DS | 2 |
| Hopper, KE | 1 |
| Fisher, G | 1 |
| Methot, G | 1 |
6 other studies available for reserpine and Fibrosarcoma
| Article | Year |
|---|---|
Interaction of diethylaminoreserpine with cells of a transplantable tumour in vivo.
Topics: Animals; Antineoplastic Agents; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relat | 1984 |
I. Tumor growth in mice with depressed capacity to mount inflammatory responses: possible role of macrophages.
Topics: Animals; Blood Cell Count; Blood Sedimentation; Corticosterone; Cyclophosphamide; Female; Fibrosarco | 1981 |
Toxicity to tumour cells of diethylaminoreserpine.
Topics: Animals; Cell Survival; Clone Cells; Female; Fibrosarcoma; Male; Mice; Mice, Inbred C3H; Reserpine; | 1980 |
Radioprotection of normal and malignant tissue in the mouse by diethylaminoreserpine.
Topics: Adenocarcinoma; Animals; Antihypertensive Agents; Cell Survival; Fibrosarcoma; Hematopoietic Stem Ce | 1981 |
Macrophages and resistance to tumours: influence of agents affecting macrophages and delayed-type hypersensitivity on resistance to tumours inducing concomitant immunity.
Topics: Animals; Carrageenan; Depression, Chemical; Fibrosarcoma; Hypersensitivity, Delayed; Immunity; Immun | 1978 |
Factors influencing the toxicity of diethylaminoethylreserpine to tumor cells: studies with four transplantable tumors.
Topics: Adenocarcinoma; Aerobiosis; Animals; Carcinoma; Female; Fibrosarcoma; Lung Neoplasms; Male; Mice; Mi | 1987 |