reserpine has been researched along with Fibromyalgia in 35 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This review highlights the potential therapeutic approaches identified in studies that used reserpine-induced myalgia (RIM) animal model that exhibits nociplastic pain-associated phenotypes." | 9.22 | Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model. ( Nagakura, Y, 2022) |
| " Recently, a rat reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical and thermal stimuli has been used in FM research." | 8.12 | Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. ( Ejiri, Y; Mizumura, K; Ota, H; Taguchi, T; Uta, D, 2022) |
| " Mechanical hyperalgesia, thermal allodynia, depressive- and anxious-related behavior, and locomotor activity were evaluated after reserpine (0." | 8.12 | Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. ( Baldasso, GM; Capasso, R; Cicco, P; de Assis, PM; Dutra, RC; Ferrarini, EG; Gouvêa, MC; Moreira, ELG; Paes, RS; Raposo, NRB, 2022) |
| "Pioglitazone significantly relieved fatigue, improved muscle performance, reduced inflammatory cytokines and enhanced antioxidant's activity, while GW9662, a known PPAR-γ antagonist, aggravated the FM manifestations in the rat model." | 8.02 | Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model. ( Attia, MH; Eid, DM; Hassan, FE; Mohamed, AS; Mohie, PM; Sakr, HI; Suliman, HS, 2021) |
| "Fibromyalgia was induced by administration of reserpine (1 mg/kg/s." | 7.85 | Evidences for amelioration of reserpine-induced fibromyalgia in rat by low dose of gamma irradiation and duloxetine. ( Abd El Fattah, MA; Kenawy, SA; Radwan, RR; Shabaan, EA; Shibrya, EE, 2017) |
| "The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms." | 7.78 | Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats. ( Nagakura, Y; Noto, T; Oe, T; Sekizawa, T; Shimizu, Y; Takahashi, M; Tamaki, K; Yoshimi, E, 2012) |
| "Fibromyalgia is a chronic pain syndrome with a multifactorial pathophysiology affecting 2-8 % of the population." | 5.91 | Stem cells therapeutic effect in a reserpine-induced fibromyalgia rat model: A possible NLRP3 inflammasome modulation with neurogenesis promotion in the cerebral cortex. ( Abdelghany, AK; Desouky, MK; Ibrahim, MFG; Mokhemer, SA, 2023) |
| "Daphnetin pretreatment attenuated the behavioral and biochemical changes induced by reserpine." | 5.62 | Daphnetin, a natural coumarin averts reserpine-induced fibromyalgia in mice: modulation of MAO-A. ( Bhatti, R; Kaur, A; Singh, AP; Singh, L, 2021) |
| "Reserpine (1 mg/kg) was subcutaneously injected once daily for three consecutive days in male Swiss mice." | 5.56 | Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. ( Brum, EDS; Dalla Corte, CL; Fialho, MFP; Fischer, SPM; Gonçalves, DF; Hartmann, DD; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Soares, FAA, 2020) |
| "Esculetin is a 6,7 dihydroxy-coumarin obtained from various plant sources such as Aesculus hippocastanum L, Ceratostigma willmottianum, Citrus limonia, etc." | 5.56 | Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A. ( Bhatti, R; Garg, S; Kaur, A; Singh, AP; Singh, L, 2020) |
| "Reserpine treatment was found to cause an increased anxiety as revealed by increased time spent in closed arm of the elevated plus maze (EPM)." | 5.51 | Ameliorative effect of imperatorin in chemically induced fibromyalgia: Role of NMDA/NFkB mediated downstream signaling. ( Bhatti, MS; Bhatti, R; Kaur, A; Singh, L; Singh, N, 2019) |
| "Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety." | 5.46 | Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats. ( Bonomini, F; Favero, G; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A; Trapletti, V, 2017) |
| " This review highlights the potential therapeutic approaches identified in studies that used reserpine-induced myalgia (RIM) animal model that exhibits nociplastic pain-associated phenotypes." | 5.22 | Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model. ( Nagakura, Y, 2022) |
| " Recently, a rat reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical and thermal stimuli has been used in FM research." | 4.12 | Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. ( Ejiri, Y; Mizumura, K; Ota, H; Taguchi, T; Uta, D, 2022) |
| " Fibromyalgia was induced by three injections once a day of reserpine at the dose of 1 mg/kg." | 4.12 | Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia. ( Cordaro, M; Cuzzocrea, S; D'Amico, R; Di Paola, D; Di Paola, R; Franco, G; Fusco, R; Genovese, T; Impellizzeri, D; Marino, Y; Siracusa, R, 2022) |
| " Mechanical hyperalgesia, thermal allodynia, depressive- and anxious-related behavior, and locomotor activity were evaluated after reserpine (0." | 4.12 | Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. ( Baldasso, GM; Capasso, R; Cicco, P; de Assis, PM; Dutra, RC; Ferrarini, EG; Gouvêa, MC; Moreira, ELG; Paes, RS; Raposo, NRB, 2022) |
| "The present study investigated the efficacy of cationic liposome-encapsulated carotenoids (lutein or beta-carotene) as a treatment in an animal model of fibromyalgia (FM)." | 4.02 | Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model. ( Elkholy, NS; Mohammed, HS; Shafaa, MW, 2021) |
| " Importantly, we found different profiles of PORH in animals pretreated with reserpine (accelerated peak and reduced half recovery time), streptozotocin (increased peak), or subjected to muscle contraction in stretching (delayed peak), approaches used as experimental models to study fibromyalgia, type II diabetes mellitus, and soreness induced by unaccustomed eccentric exercise, respectively." | 4.02 | Detection of blood flow perfusion and post - occlusive reactive hyperemia in the skeletal muscle of rats. ( Ascenso, R; da Silva-Santos, JE; Souza-Silva, E; Tonussi, CR, 2021) |
| "Pioglitazone significantly relieved fatigue, improved muscle performance, reduced inflammatory cytokines and enhanced antioxidant's activity, while GW9662, a known PPAR-γ antagonist, aggravated the FM manifestations in the rat model." | 4.02 | Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model. ( Attia, MH; Eid, DM; Hassan, FE; Mohamed, AS; Mohie, PM; Sakr, HI; Suliman, HS, 2021) |
| "To produce a fibromyalgia mouse model, wild-type mice were administered an intraperitoneal injection of reserpine once a day for three days, and two primary experiments were performed." | 3.96 | Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model. ( Doi, A; Nakata, T; Shin, MC; Uta, D; Yoshimura, M, 2020) |
| "Fibromyalgia was induced by administration of reserpine (1 mg/kg/s." | 3.85 | Evidences for amelioration of reserpine-induced fibromyalgia in rat by low dose of gamma irradiation and duloxetine. ( Abd El Fattah, MA; Kenawy, SA; Radwan, RR; Shabaan, EA; Shibrya, EE, 2017) |
| "This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)." | 3.80 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
| "The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms." | 3.78 | Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats. ( Nagakura, Y; Noto, T; Oe, T; Sekizawa, T; Shimizu, Y; Takahashi, M; Tamaki, K; Yoshimi, E, 2012) |
| "Fibromyalgia is a chronic pain syndrome with a multifactorial pathophysiology affecting 2-8 % of the population." | 1.91 | Stem cells therapeutic effect in a reserpine-induced fibromyalgia rat model: A possible NLRP3 inflammasome modulation with neurogenesis promotion in the cerebral cortex. ( Abdelghany, AK; Desouky, MK; Ibrahim, MFG; Mokhemer, SA, 2023) |
| "Fibromyalgia is a potentially disabling chronic disease, characterized by widespread pain and a range of comorbidities such as hypertension." | 1.62 | Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice. ( Brusco, I; Justino, AB; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Silva, CR, 2021) |
| "Reserpine caused hyperalgesia on the mechanical and thermal hyperalgesia on the 4th day was reverted by recombinant Phα1β (0." | 1.62 | Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia. ( Assis Ferreira, LC; Carvalho Dos Santos, D; Garcia Mendes, MP; Gomez, MV; José de Castro Junior, C; Rezende, MJS; Rigo, FK, 2021) |
| "Fibromyalgia is characterized by the amplification of central nervous system pain with concomitant fatigue, sleep, mood disorders, depression, and anxiety." | 1.62 | Phoneutria nigriventer Tx3-3 peptide toxin reduces fibromyalgia symptoms in mice. ( Antunes, FTT; Campos, MM; Correa, ÁP; de Oliveira, IB; de Souza, AH; do Nascimento Cordeiro, M; Gomez, MV; Klein, CP; Pedron, C; Rebelo, IN, 2021) |
| "Daphnetin pretreatment attenuated the behavioral and biochemical changes induced by reserpine." | 1.62 | Daphnetin, a natural coumarin averts reserpine-induced fibromyalgia in mice: modulation of MAO-A. ( Bhatti, R; Kaur, A; Singh, AP; Singh, L, 2021) |
| "Postreserpine recordings were taken on alternate days for 21 days." | 1.56 | Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers. ( Alfosea-Cuadrado, G; Blasco-Serra, A; Cervera-Ferri, A; González-Soler, EM; Lloret, A; Martínez-Ricós, J; Teruel-Martí, V; Valverde-Navarro, AA, 2020) |
| "Reserpine (1 mg/kg) was subcutaneously injected once daily for three consecutive days in male Swiss mice." | 1.56 | Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. ( Brum, EDS; Dalla Corte, CL; Fialho, MFP; Fischer, SPM; Gonçalves, DF; Hartmann, DD; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Soares, FAA, 2020) |
| "Esculetin is a 6,7 dihydroxy-coumarin obtained from various plant sources such as Aesculus hippocastanum L, Ceratostigma willmottianum, Citrus limonia, etc." | 1.56 | Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A. ( Bhatti, R; Garg, S; Kaur, A; Singh, AP; Singh, L, 2020) |
| "Reserpine treatment was found to cause an increased anxiety as revealed by increased time spent in closed arm of the elevated plus maze (EPM)." | 1.51 | Ameliorative effect of imperatorin in chemically induced fibromyalgia: Role of NMDA/NFkB mediated downstream signaling. ( Bhatti, MS; Bhatti, R; Kaur, A; Singh, L; Singh, N, 2019) |
| "Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and a reduction in patients' quality of life, without specific pathophysiology or appropriate treatment." | 1.51 | Kinins and their B ( Brusco, I; Cunha, TM; Ferreira, J; Fischer, S; Justino, AB; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Silva, CR, 2019) |
| "Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression and anxiety." | 1.46 | Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats. ( Bonomini, F; Favero, G; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A; Trapletti, V, 2017) |
| "Fibromyalgia is a prevalent and burdensome disorder characterized by chronic widespread pain and complex comorbid symptoms." | 1.35 | Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia. ( Aoki, T; Matsuoka, N; Nagakura, Y; Oe, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 13 (37.14) | 24.3611 |
| 2020's | 20 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Nagakura, Y | 5 |
| Ejiri, Y | 1 |
| Uta, D | 2 |
| Ota, H | 1 |
| Mizumura, K | 1 |
| Taguchi, T | 1 |
| Cordaro, M | 1 |
| Siracusa, R | 1 |
| D'Amico, R | 1 |
| Genovese, T | 1 |
| Franco, G | 1 |
| Marino, Y | 1 |
| Di Paola, D | 1 |
| Cuzzocrea, S | 1 |
| Impellizzeri, D | 1 |
| Di Paola, R | 1 |
| Fusco, R | 1 |
| Álvarez-Pérez, B | 2 |
| Deulofeu, M | 2 |
| Homs, J | 1 |
| Merlos, M | 2 |
| Vela, JM | 2 |
| Verdú, E | 2 |
| Boadas-Vaello, P | 2 |
| Ferrarini, EG | 1 |
| Paes, RS | 1 |
| Baldasso, GM | 1 |
| de Assis, PM | 1 |
| Gouvêa, MC | 1 |
| Cicco, P | 1 |
| Raposo, NRB | 1 |
| Capasso, R | 1 |
| Moreira, ELG | 1 |
| Dutra, RC | 1 |
| Bagó-Mas, A | 1 |
| Mokhemer, SA | 1 |
| Desouky, MK | 1 |
| Abdelghany, AK | 1 |
| Ibrahim, MFG | 1 |
| Atta, AA | 1 |
| Ibrahim, WW | 1 |
| Mohamed, AF | 1 |
| Abdelkader, NF | 1 |
| Ikeda, N | 1 |
| Kawasaki, M | 1 |
| Baba, K | 1 |
| Nishimura, H | 1 |
| Fujitani, T | 1 |
| Suzuki, H | 1 |
| Matsuura, T | 1 |
| Ohnishi, H | 1 |
| Shimizu, M | 1 |
| Sanada, K | 1 |
| Nishimura, K | 1 |
| Yoshimura, M | 2 |
| Maruyama, T | 1 |
| Conway-Campbell, BL | 1 |
| Onaka, T | 1 |
| Teranishi, H | 1 |
| Hanada, R | 1 |
| Ueta, Y | 1 |
| Sakai, A | 1 |
| Miwa, M | 2 |
| Yoshida, M | 2 |
| Miura, R | 2 |
| Tanei, S | 1 |
| Tsuji, M | 1 |
| Takeda, H | 1 |
| Blasco-Serra, A | 2 |
| Alfosea-Cuadrado, G | 1 |
| Cervera-Ferri, A | 2 |
| González-Soler, EM | 2 |
| Lloret, A | 1 |
| Martínez-Ricós, J | 1 |
| Teruel-Martí, V | 2 |
| Valverde-Navarro, AA | 2 |
| Singh, L | 3 |
| Kaur, A | 3 |
| Garg, S | 1 |
| Singh, AP | 2 |
| Bhatti, R | 3 |
| Brum, EDS | 1 |
| Fialho, MFP | 1 |
| Fischer, SPM | 1 |
| Hartmann, DD | 1 |
| Gonçalves, DF | 1 |
| Scussel, R | 3 |
| Machado-de-Ávila, RA | 3 |
| Dalla Corte, CL | 1 |
| Soares, FAA | 1 |
| Oliveira, SM | 3 |
| Nakata, T | 1 |
| Doi, A | 1 |
| Shin, MC | 1 |
| Pedron, C | 1 |
| Antunes, FTT | 1 |
| Rebelo, IN | 1 |
| Campos, MM | 1 |
| Correa, ÁP | 1 |
| Klein, CP | 2 |
| de Oliveira, IB | 1 |
| do Nascimento Cordeiro, M | 1 |
| Gomez, MV | 3 |
| de Souza, AH | 2 |
| Brusco, I | 2 |
| Justino, AB | 2 |
| Silva, CR | 2 |
| Garcia Mendes, MP | 1 |
| Carvalho Dos Santos, D | 1 |
| Rezende, MJS | 1 |
| Assis Ferreira, LC | 1 |
| Rigo, FK | 1 |
| José de Castro Junior, C | 1 |
| Elkholy, NS | 1 |
| Shafaa, MW | 1 |
| Mohammed, HS | 1 |
| Souza-Silva, E | 1 |
| Ascenso, R | 1 |
| Tonussi, CR | 1 |
| da Silva-Santos, JE | 1 |
| Hassan, FE | 1 |
| Sakr, HI | 1 |
| Mohie, PM | 1 |
| Suliman, HS | 1 |
| Mohamed, AS | 1 |
| Attia, MH | 1 |
| Eid, DM | 1 |
| Favero, G | 1 |
| Trapletti, V | 1 |
| Bonomini, F | 1 |
| Stacchiotti, A | 1 |
| Lavazza, A | 1 |
| Rodella, LF | 1 |
| Rezzani, R | 1 |
| Hernandez-Leon, A | 1 |
| Fernández-Guasti, A | 1 |
| Martínez, A | 1 |
| Pellicer, F | 1 |
| González-Trujano, ME | 1 |
| Siemian, JN | 1 |
| Shang, L | 1 |
| Seaman, RW | 1 |
| Zhu, Q | 1 |
| Zhang, Y | 1 |
| Li, JX | 1 |
| Uchida, M | 1 |
| Kobayashi, O | 1 |
| Saito, H | 1 |
| Singh, N | 1 |
| Bhatti, MS | 1 |
| De la Luz-Cuellar, YE | 1 |
| Rodríguez-Palma, EJ | 1 |
| Franco-Enzástiga, Ú | 1 |
| Salinas-Abarca, AB | 1 |
| Delgado-Lezama, R | 1 |
| Granados-Soto, V | 1 |
| Fischer, S | 1 |
| Cunha, TM | 1 |
| Ferreira, J | 2 |
| da Costa Lopes, AM | 1 |
| Castro, CJ | 1 |
| Pereira, EM | 1 |
| da Silva, CA | 1 |
| da Silva, JF | 1 |
| Escrihuela-Vidal, F | 1 |
| Martínez-Expósito, F | 1 |
| Blasco-Ausina, MC | 1 |
| Martínez-Bellver, S | 1 |
| Shibrya, EE | 1 |
| Radwan, RR | 1 |
| Abd El Fattah, MA | 1 |
| Shabaan, EA | 1 |
| Kenawy, SA | 1 |
| Wells, JA | 1 |
| Shibata, S | 1 |
| Fujikawa, A | 1 |
| Takahashi, M | 2 |
| Saga, T | 1 |
| Aoki, I | 1 |
| Oe, T | 2 |
| Aoki, T | 1 |
| Matsuoka, N | 1 |
| Sluka, KA | 1 |
| Noto, T | 1 |
| Sekizawa, T | 1 |
| Yoshimi, E | 1 |
| Tamaki, K | 1 |
| Shimizu, Y | 1 |
1 review available for reserpine and Fibromyalgia
| Article | Year |
|---|---|
Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model.
Topics: Animals; Chronic Pain; Disease Models, Animal; Fibromyalgia; Humans; Myalgia; Reserpine | 2022 |
34 other studies available for reserpine and Fibromyalgia
| Article | Year |
|---|---|
Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model.
Topics: Animals; Fibromyalgia; Formaldehyde; Nociception; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, S | 2022 |
Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia.
Topics: Animals; Etanercept; Fibromyalgia; Hyperalgesia; Infliximab; Models, Theoretical; Nociception; p38 M | 2022 |
Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition.
Topics: Animals; Chronic Pain; Disease Models, Animal; Fibromyalgia; Mice; Pregabalin; Reserpine | 2022 |
Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice.
Topics: Analgesics; Animals; Cannabis; Disease Models, Animal; Dronabinol; Fibromyalgia; Hyperalgesia; Mice; | 2022 |
Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.
Topics: Analgesics; Animals; Chronic Pain; Disease Models, Animal; Female; Fibromyalgia; Gliosis; Hyperalges | 2022 |
Stem cells therapeutic effect in a reserpine-induced fibromyalgia rat model: A possible NLRP3 inflammasome modulation with neurogenesis promotion in the cerebral cortex.
Topics: Animals; Beclin-1; Brain Injuries; Caspase 1; Cerebral Cortex; Fibromyalgia; HMGB Proteins; Inflamma | 2023 |
Targeting α7-nAChR by galantamine mitigates reserpine-induced fibromyalgia-like symptoms in rats: Involvement of cAMP/PKA, PI3K/AKT, and M1/M2 microglia polarization.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Fibromyalgia; Galantamine; Microglia; Phosphatidyl | 2023 |
Chemogenetic Activation of Oxytocin Neurons Improves Pain in a Reserpine-induced Fibromyalgia Rat Model.
Topics: Animals; Fibromyalgia; Humans; Luminescent Proteins; Neurons; Oxytocin; Pain; Rats; Rats, Transgenic | 2023 |
Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.
Topics: Analgesics; Animals; Disease Models, Animal; Facial Expression; Fibromyalgia; Male; Pain; Rats; Rats | 2019 |
Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers.
Topics: Animals; Antipsychotic Agents; Brain Waves; Electroencephalography; Fibromyalgia; Hippocampus; Male; | 2020 |
Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A.
Topics: Analgesics; Animals; Female; Fibromyalgia; Glutamic Acid; Glutathione; Interleukin-1beta; Lipid Pero | 2020 |
Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Fatigue; Fibromyalgia; Male; Mice; Mi | 2020 |
Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Fibromyalgia; Gait; Heart Rate; Male; Mice; M | 2020 |
Phoneutria nigriventer Tx3-3 peptide toxin reduces fibromyalgia symptoms in mice.
Topics: Analgesics; Anesthetics; Animals; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Male; Mice; Ne | 2021 |
Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Behavior, Animal; Captopril; Disease Models, Anim | 2021 |
Daphnetin, a natural coumarin averts reserpine-induced fibromyalgia in mice: modulation of MAO-A.
Topics: Animals; Disease Models, Animal; Fibromyalgia; Mice; Monoamine Oxidase; Reserpine; Umbelliferones | 2021 |
Effects of intravenous administration of recombinant Phα1β toxin in a mouse model of fibromyalgia.
Topics: Administration, Intravenous; Analgesics; Animals; Disease Models, Animal; Fibromyalgia; Hyperalgesia | 2021 |
Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model.
Topics: Animals; Antioxidants; Carotenoids; Female; Fibromyalgia; Liposomes; Lutein; Pain; Rats; Reserpine | 2021 |
Detection of blood flow perfusion and post - occlusive reactive hyperemia in the skeletal muscle of rats.
Topics: Animals; Blood Flow Velocity; Female; Fibromyalgia; Hemodynamics; Hyperemia; Microcirculation; Muscl | 2021 |
Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model.
Topics: Animals; Fatigue; Fibromyalgia; Humans; Male; Muscle, Skeletal; Pioglitazone; PPAR gamma; Rats; Rats | 2021 |
Oral Supplementation of Melatonin Protects against Fibromyalgia-Related Skeletal Muscle Alterations in Reserpine-Induced Myalgia Rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Antioxidants; Body Weight; Disease Models, Anim | 2017 |
Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Fluoxetine; Hyperalgesia; Ovariectomy; Pain; | 2019 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Id | 2019 |
Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia.
Topics: Animals; Body Temperature; Colon; Disease Models, Animal; Feces; Fibromyalgia; Gastric Emptying; Gas | 2019 |
Ameliorative effect of imperatorin in chemically induced fibromyalgia: Role of NMDA/NFkB mediated downstream signaling.
Topics: Adrenergic Uptake Inhibitors; Animals; Dose-Response Relationship, Drug; Fibromyalgia; Furocoumarins | 2019 |
Blockade of spinal α
Topics: Animals; Astrocytes; Female; Fibromyalgia; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia | 2019 |
Kinins and their B
Topics: Animals; Behavior, Animal; Bradykinin; Disease Models, Animal; Fibromyalgia; Gene Knockout Technique | 2019 |
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia | 2014 |
Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Depression; Disease Models, Animal; Exploratory Behavior; Fee | 2015 |
Evidences for amelioration of reserpine-induced fibromyalgia in rat by low dose of gamma irradiation and duloxetine.
Topics: Analgesics; Animals; Chemoradiotherapy; Duloxetine Hydrochloride; Fibromyalgia; Gamma Rays; Male; Ra | 2017 |
Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli.
Topics: Animals; Biogenic Amines; Brain; Brain Mapping; Disease Models, Animal; Electric Stimulation; Fibrom | 2017 |
Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia.
Topics: Adrenergic Uptake Inhibitors; Animals; Biogenic Amines; Central Nervous System; Depressive Disorder; | 2009 |
Is it possible to develop an animal model of fibromyalgia?
Topics: Adrenergic Uptake Inhibitors; Animals; Biogenic Amines; Disease Models, Animal; Fibromyalgia; Humans | 2009 |
Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury rats.
Topics: Animals; Chronic Pain; Constriction; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Male; Neura | 2012 |